Author(s)

Zhang Yifan ^1,2

Affiliation(s)

¹ Shanxi Bethune Hospital, Taiyuan, Shanxi, 030032, China; Shanxi Academy of Medical Sciences, Taiyuan, Shanxi, 030032, China
² Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, 030032, China; Tongji Shanxi Hospital, Taiyuan, Shanxi, 030032, China

Corresponding Author

Zhang Yifan

ABSTRACT

To evaluate the efficacy of risk assessment combined with stratified nursing interventions in preventing chemotherapy-induced oral mucositis (OM) in acute leukemia patients, this randomized controlled trial (N = 80) evaluated the clinical efficacy of a risk-stratified nursing framework in mitigating chemotherapy-induced oral mucositis (OM) in patients with acute leukemia. The experimental group (n = 40) received individualized prophylactic interventions based on baseline risk assessment, including cryotherapy, topical growth factor administration, nutritional optimization, and preemptive analgesia, whereas the control group (n = 40) received standard institutional care. The results demonstrated that risk-based stratification significantly reduced the incidence of OM (52.50% vs. 80.00%, P = 0.009) and alleviated its severity (P = 0.001). In addition, the experimental group showed significantly lower Visual Analogue Scale (VAS) pain scores (3.24±1.15 vs. 5.81±1.42), shorter mucosal healing time (6.52±1.83 vs. 10.28 ± 2.45 days), and higher scores in quality of life (EORTC QLQ-C30) and nursing compliance (all P < 0.05). These findings suggest that risk stratification enables early identification of high-risk patients, effectively reduces the incidence and severity of OM, and contributes to improved clinical outcomes and treatment tolerance in patients with acute leukemia.

KEYWORDS

Acute leukemia; chemotherapy; Oral mucositis; Risk assessment; Stratified nursing; Precision nursing

CITE THIS PAPER

Zhang Yifan. Efficacy of Risk-Stratified Nursing Interventions on Chemotherapy-Induced Oral Mucositis in Acute Leukemia Patients. MEDS Clinical Medicine (2026). Vol. 7, No.2, 30-36. DOI: http://dx.doi.org/10.23977/medsc.2026.070205.

REFERENCES

[1] de Farias Gabriel A, Silveira F M, Curra M, et al. Risk factors associated with the development of oral mucositis in pediatric oncology patients: Systematic review and meta‐analysis[J]. Oral Diseases, 2022, 28(4): 1068-1084.
[2] Karlsson C, Bohm N, Andersson J S, et al. Prospective study on health-related quality of life, oral mucositis and oral health on during treatment of head and neck cancer[J]. BMC Oral Health, 2024, 24(1): 697.
[3] Ramezani V, Ghadirian S, Shabani M, et al. Efficacy of curcumin for amelioration of radiotherapy-induced oral mucositis: a preliminary randomized controlled clinical trial[J]. BMC cancer, 2023, 23(1): 354.
[4] Gamal A, Abd El Mabood S, Shalan H M, et al. Extended oral care can prevent oral mucositis in immunocompromised acute lymphoblastic leukemia ghildren[J]. Egyptian Journal of Cancer and Biomedical Research, 2022, 6(1): 11-17.
[5] Gu Y, Chen N, He M, et al. The Study Progress and Analysis of Preventive Measures of Nursing Care for Chemotherapy-Induced Oral Mucositis in Pediatric Patients with Hematologic Malignancies: A Retrospective Study[J]. Journal of multidisciplinary healthcare, 2024: 5665-5673.
[6] Colella G, Boschetti C E, Vitagliano R, et al. Interventions for the prevention of oral mucositis in patients receiving cancer treatment: evidence from randomised controlled trials[J]. Current Oncology, 2023, 30(1): 967-980.

Sponsors, Associates, and Links

---

• Journal of Neurobiology and Genetics
  
  
• Medical Imaging and Nuclear Medicine
  
  
• Bacterial Genetics and Ecology
  
  
• Transactions on Cancer
  
  
• Journal of Biophysics and Ecology
  
  
• Journal of Animal Science and Veterinary
  
  
• Academic Journal of Biochemistry and Molecular Biology
  
  
• Transactions on Cell and Developmental Biology
  
  
• Rehabilitation Engineering & Assistive Technology
  
  
• Orthopaedics and Sports Medicine
  
  
• Hematology and Stem Cell
  
  
• Journal of Intelligent Informatics and Biomedical Engineering
  
  
• MEDS Basic Medicine
  
  
• MEDS Stomatology
  
  
• MEDS Public Health and Preventive Medicine
  
  
• MEDS Chinese Medicine
  
  
• Journal of Enzyme Engineering
  
  
• Advances in Industrial Pharmacy and Pharmaceutical Sciences
  
  
• Bacteriology and Microbiology
  
  
• Advances in Physiology and Pathophysiology
  
  
• Journal of Vision and Ophthalmology
  
  
• Frontiers of Obstetrics and Gynecology
  
  
• Digestive Disease and Diabetes
  
  
• Advances in Immunology and Vaccines
  
  
• Nanomedicine and Drug Delivery
  
  
• Cardiology and Vascular System
  
  
• Pediatrics and Child Health
  
  
• Journal of Reproductive Medicine and Contraception
  
  
• Journal of Respiratory and Lung Disease
  
  
• Journal of Bioinformatics and Biomedicine