Author(s)

Miao Liu ¹, Chanchan Hu ¹

Affiliation(s)

¹ The Affiliated Hospital of Chengde Medical University, Chengde, Hebei, 067000, China

Corresponding Author

Chanchan Hu

ABSTRACT

Colorectal cancer (CRC) is a highly prevalent malignancy of the digestive system, and its initiation and progression are closely associated with the host immune status. Alterations in the proportions of peripheral blood immune cell subsets can dynamically reflect the level of antitumor immune responses and are of considerable value for the early diagnosis, staging assessment, and prognostic prediction of CRC. This article systematically reviews the characteristics of proportional changes in peripheral blood immune cell subsets-such as T lymphocytes, natural killer (NK) cells, and myeloid-derived suppressor cells (MDSCs)-across different stages of CRC. Current controversies and limitations in existing studies are analyzed, and future directions are proposed, including the standardization of detection methods, expansion of sample sizes, and implementation of multicenter collaborative studies to clarify the associations between immune cell proportions and tumor stage. This review aims to provide a theoretical basis for immune monitoring and individualized treatment of CRC.

KEYWORDS

Colorectal Cancer; Tumor Stage; Peripheral Blood; Immune Cell Subsets

CITE THIS PAPER

Miao Liu, Chanchan Hu. Changes in the Proportions of Peripheral Blood Immune Cell Subsets across Different Stages of Colorectal Cancer. MEDS Clinical Medicine (2026) Vol. 7: 58-63. DOI: http://dx.doi.org/10.23977/medsc.2026.070107.

REFERENCES

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[2] Zong, M. T., Chu, X. L., Xue, P., et al. (2025). A literature-based study on the distribution characteristics of traditional Chinese medicine syndromes and syndrome elements in colorectal cancer. China Medical Herald, 22(27), 93–98, 118.
[3] Li, H., Cui, L. H., Wang, X. H., et al. (2025). The relationship between colorectal cancer and small intestinal bacterial overgrowth. China Medical Herald, 22(24), 54–57.
[4] Wu, T., Li, T., Zhang, C., et al. (2026). Author correction: A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer. Nature Communications, 17(1), 609.
[5] DuPre, N., Babarinde, O., Adhikari, J., et al. (2026). Urinary metabolites of 1,3-butadiene, benzene, and toluene and colorectal cancer incidence: A clinical case–control study. Cancer Causes & Control, 37(2), 27.

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