Author(s)

Zimo Feng ¹

Affiliation(s)

¹ Camford Royal School, Sitongbei, South Xiangshan Road, Haidian District, Beijing, China

Corresponding Author

Zimo Feng

ABSTRACT

Self-repairing polymer materials have shown broad application prospects in the biomedical field due to their ability to self-repair after damage. They play a key role in extending equipment life, ensuring reduced quality of use, reducing manufacturing costs, and protecting environmental quality. Due to the widespread application of self-healing materials, the limitations of self-healing polymer materials have gradually been magnified, and there are differences and diversity in the research and application of self-healing materials for different polymers. In addition, there are promising development prospects in biomedical applications such as drug delivery systems, medical coatings and implant materials, and flexible bioelectronics.

KEYWORDS

Self-Healing Polymer Materials, Biomedical Applications, Polymers

CITE THIS PAPER

Zimo Feng, Research Progress on Biomedical Self-Healing Polymer Materials. Analytical Chemistry: A Journal (2025) Vol. 4: 73-81. DOI: http://dx.doi.org/10.23977/analc.2025.040110.

REFERENCES

[1] Li B, Cao P-F, Saito T, et al. Intrinsically Self-Healing Polymers: From Mechanistic Insight to Current Challenges [J]. Chemical Reviews, 2023, 123(2): 701-735.
[2] Xiao Wei. Study of self-repaired polymer systems based on dynamic covalent bonds [D], Jiangxi: Jiangxi Science and Technology Normal University, 2022.
[3] Xiaohua Li, Shuang Liang, Na Li, et al. Self repairing polymer coatings based on Diels Alder reaction: research progress on two-dimensional nano material reinforcement strategy and performance optimization [J]. Paint industry, 2025, 55(08): 83-88.
[4] Chen X, Wudl F, Mal A K, et al. New Thermally Remendable Highly Cross-Linked Polymeric Materials [J]. Macromolecules, 2003, 36(6): 1802-1807.
[5] Yifei Zhou. Synthetic study toward the 6/8/6 core skeleton of taxol [D], Heilongjiang: Harbin Institute of Technology, 2020. 
[6] Ningning Li. Synthesis of important intermediates of Viniglol [D], Jilin: Jilin University, 2019. 
[7] Yang Q, Njardarson J T, Draghici C, et al. Total Synthesis of Vinigrol [J]. Angewandte Chemie International Edition, 2013,52:8648-8651.
[8] Long Min, Chuangchuang Li. Progress in the Total Synthesis of High Difficulty Diterpenoid Molecule Viniglol [J]. Science Bulletin,2021, 66(25): 3230-3240.
[9] Zi Fan. Review of the Performance and Applications of Self-Healing Polymer Materials [J]. Material Sciences, 2025, 15(03): 442-452.
[10] Utrera-Barrios S, Verdejo R, López-Manchado M A, et al. Evolution of self-healing elastomers, from extrinsic to combined intrinsic mechanisms: a review [J]. Materials Horizons, 2020,7:2860-2881.
[11] Andreu A, Lee H, Kang J, et al. Self-Healing Materials for 3D Printing [J]. Advanced Functional Materials, 2024, 34: 2315046.
[12] Xin Xu. Preparation and controlled release properties of disulfide bridged cyclodextrin hydrogel drug carrier [D]. Qilu University of Technology, 2024.
[13] Shamsudin M S B S, Bin Abdul Aziz A S, Dabwan A H A. Synthesis of Biodiesel from Waste Cooking Oil by Alkali Catalyzed Transesterification [J]. Journal of Physics: Conference Series, 2020, 1532: 012016.
[14] Yanni Zhang, Yan Gao. Research progress on the application of self-healing materials based on boronic ester bonds in electrolytes [J]. Domestic and foreign energy, 2024, 29(02): 31-38.
[15] Longhua Zeng, Yidan Zhang, Jingping Yao, et al. Preparation and self-healing properties of high strength, rapid self-healing double-cross linked structural polyvinyl alcohol hydrogel [J]. Journal of Jinggangshan University (Natural Science Edition) 2025, 46(01): 45-50.
[16] Yunfei Wang, Wen Di, Lihua Qiu. Targeted study of VEGF modified TNP-470 nanoparticles on tumor bearing nude mice [J]. Progress in Modern Obstetrics and Gynecology,2012, 21(11): 852-856.
[17] Porcile C, Bajetto A, Barbieri F, et al. Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12) stimulates ovarian cancer cell growth through the EGF receptor transactivation [J]. Experimental Cell Research, 2005,308:241-253.
[18] Yu T, Wu Y, Huang Y, et al. RNAi Targeting CXCR4 Inhibits Tumor Growth Through Inducing Cell Cycle Arrest and Apoptosis [J]. Molecular Therapy, 2016,398-407.
[19] Huang Y, Xiao L, Zhou J, et al. Strong Tough Polyampholyte Hydrogels via the Synergistic Effect of Ionic and Metal–Ligand Bonds [J]. Advanced Functional Materials, 2021, 31:2103917.
[20] Xu J, Zhang H, Guo Z, et al. Fully physical crosslinked BSA-based conductive hydrogels with high strength and fast self-recovery for human motion and wireless electrocardiogram sensing [J]. International Journal of Biological Macromolecules, 2023,230:123195.
[21] Ziyu Guo, Sijia Tang, Zhiyu Zhang, et al. Research progress of self-healing composite hydrogels and flexible sensors [J]. New Chemical Materials,2025, 53(09): 64-69.
[22] Jing Luo, Kaiyun Wu, Yaxin Chen. Research progress on preparation and application of self-healing microcapsules [J]. Chinese Powder Technology,2026,32(2):1-15.
[23] Loxley A, Vincent B. Preparation of Poly(methylmethacrylate) Microcapsules with Liquid Cores [J]. Journal of Colloid and Interface Science, 1998,208:49-62.
[24] Zotiadis C, Patrikalos I, Loukaidou V, et al. Self-healing coatings based on poly(urea-formaldehyde) microcapsules: In situ polymerization, capsule properties and application [J]. Progress in Organic Coatings, 2021,161:106475.
[25] Shuo Yao. Synthesis of self-healing microcapsules reinforced with novel nano antibacterial inorganic fillers and their application in dental resins [D]. Shandong University, 2023.
[26] Qiangsheng Dong. Preparation and Repair Mechanism of Self repairing Coating on Medical Magnesium Alloy Surface [D]. Southeast University, 2022.
[27] Shangzhi Yue, Zhongzhen Yu, Dan Yang. Research progress on self-healing dielectric elastomer actuators [J]. Journal of Polymer Science,2025, 56(06): 881-902.

Sponsors, Associates, and Links

---

• Forging and Forming
  
  
• Composites and Nano Engineering
  
  
• Journal of Materials, Processing and Design
  
  
• Metallic foams
  
  
• Smart Structures, Materials and Systems
  
  
• Chemistry and Physics of Polymers
  
  
• Modern Physical Chemistry Research
  
  
• Inorganic Chemistry: A Journal
  
  
• Organic Chemistry: A Journal
  
  
• Progress in Materials Chemistry and Physics
  
  
• Transactions on Industrial Catalysis
  
  
• Fuels and Combustion
  
  
• Casting, Welding and Solidification
  
  
• Journal of Membrane Technology
  
  
• Journal of Heat Treatment and Surface Engineering
  
  
• Trends in Biochemical Engineering
  
  
• Ceramic and Glass Technology
  
  
• Transactions on Metals and Alloys
  
  
• High Performance Structures and Materials
  
  
• Rheology Letters
  
  
• Plasticity Frontiers
  
  
• Corrosion and Wear of Materials
  
  
• Fluids, Heat and Mass Transfer
  
  
• International Journal of Geochemistry
  
  
• Diamond and Carbon Materials
  
  
• Advances in Magnetism and Magnetic Materials
  
  
• Advances in Fuel Cell
  
  
• Journal of Biomaterials and Biomechanics