Author(s)

Wang Yongfang ¹, Tang Weiqi ¹, Shi Yongqiang ¹

Affiliation(s)

¹ Department of Pathology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China

Corresponding Author

Wang Yongfang

ABSTRACT

A retrospective analysis of 83 endometrioid adenocarcinoma (EA) tissue samples and 83 benign disease controls, using the EnVision method to evaluate microsatellite instability (MSI) status and SOX2 expression, revealed that SOX2 expression was significantly higher in EA tissues than in controls (P<0.001). Its expression correlated with higher histological grade, deeper myometrial invasion, lymph node metastasis, and advanced FIGO stage (P<0.05), but not with age or menopausal status. A negative correlation was observed between SOX2 expression and MSI (P=0.025). These findings indicate that SOX2 overexpression is associated with EA pathogenesis and negatively correlates with MSI, suggesting its potential as a biomarker for prognosis and targeted therapy.

KEYWORDS

Endometrioid Adenocarcinoma, SOX2, Mismatch Repair Deficiency, Microsatellite Instability

CITE THIS PAPER

Wang Yongfang, Tang Weiqi, Shi Yongqiang, Expression and Clinical Significance of Mismatch Repair Deficiency/Microsatellite Instability and SOX2 in Endometrioid Adenocarcinoma. MEDS Clinical Medicine (2025) Vol. 6: 91-95. DOI: http://dx.doi.org/10.23977/medsc.2025.060513.

REFERENCES

[1] Crosbie E.J., Kitson S.J., McAlpine J.N., Mukhopadhyay A., Powell M.E., Singh N. (2022)Endometrial cancer. Lancet, 399(10333), 1412-1428.
[2] Yang J., Xu Z.J., Zhu W.D., Fan X.S., Rao Q., Liu Y., Zhou X.J. (2024) Expert consensus on microsatellite instability (MSI) detection techniques. Journal of Clinical and Experimental Pathology, 40(03), 228-235.
[3] Colomba E., Alexandre J., Le Teuff G., Bendifallah S., Canova K., Raimond E., Gouy S., Leary A., Maulard A., Pautier P., Chargari C., Morice P., Genestie C., & Bentivegna E. (2023) Response to first line platinum-based chemotherapy in mismatch repair deficient/microsatellite instability high endometrial carcinoma. Gynecologic Oncology, 169.
[4] Tang K., Liu J., Liu B., Wang X., Zhang N., He S., Xu Z. (2022) SOX2 contributes to invasion and poor prognosis of gastric cancer: A meta-analysis. Medicine, 101(36), e30384.

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