Author(s)

Zhiming Cao ¹

Affiliation(s)

¹ Woodberry Forest School, 898 Woodberry Forest Road, Montford, VA 22960, USA

Corresponding Author

Zhiming Cao

ABSTRACT

Red blood cells (RBCs) are ideal for research into drug delivery due to their high biocompatibility and ability to circulate throughout the human body. First, we isolated the RBCs and coated them with a silica film using tetraethyl orthosilicate (TMOS) and water. Then, we applied a polar polymer layer on top of the film and etched away the inner silica shell using a BOE solvent. This ensured that the remaining gel exhibited cell-like compliance, similar to that of human RBCs. This enabled the gel to deform while traversing the capillaries. Ultimately, we obtained a double-layered polymer membrane. We can use the characteristics of RBCs to attach drugs to the inner wall of the polymer layer. This model can treat systemic diseases with high targeting specificity and a long cycle. Further clinical trials are needed for future clinical applications.

KEYWORDS

LBL, Red Blood Cells, Functional Improvement, Artificial Red Blood Cells

CITE THIS PAPER

Zhiming Cao, Experimental and Analytical Improvement of Erythrocyte Function by LBL Self-Assembly. MEDS Public Health and Preventive Medicine (2025) Vol. 5: 13-19. DOI: http://dx.doi.org/10.23977/phpm.2025.050303.

REFERENCES

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[2] BOGDANOVA A, KAESTNER L. Advances in red blood cells research[J]. Cells, 2024, 13(4): 359.
[3] MENG D, YANG S, YANG Y, et al. Synergistic chemotherapy and phototherapy based on red blood cell biomimetic nanomaterials[J]. Journal of Controlled Release, 2022, 352: 146-162.
[4] GUO J, AGOLA J O, SERDA R, et al. Biomimetic Rebuilding of Multifunctional Red Blood Cells: Modular Design Using Functional Components[J]. ACS Nano, 2020, 14(7): 7847-7859.
[5] ZHANG Y, XU J, WANG B. Artificially engineered red blood cells for universal blood transfusion[J]. Matter, 2025, 8(2): 101935.

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