Advances in the extraction and pharmacological effects of total flavonoids in Chinese herbal medicines
DOI: 10.23977/medcm.2025.070203 | Downloads: 11 | Views: 370
Author(s)
Wang Xiang 1, Yang Wenying 1, Wen Jing 1, Chen Linjiusheng 1, Cao Xuan 1
Affiliation(s)
1 Hunan Agricultural University, Changsha, Hunan, 410128, China
Corresponding Author
Wang XiangABSTRACT
In recent years, the research in the field of flavonoids has been deepening, their extraction methods have been updated, and their pharmacological effects have been explored, and many new active effects have been discovered, providing new ideas for related fields. This paper provides a systematic review and elaboration on the basic properties, distribution, extraction methods and application cases of flavonoids, as well as some of the deeply researched pharmacological effects of total flavonoids, and discusses the challenges and prospects of total flavonoids in traditional Chinese medicines nowadays.
KEYWORDS
Chinese herbal medicine; total flavonoids; extraction methods; pharmacological effects; reviewCITE THIS PAPER
Wang Xiang, Yang Wenying, Wen Jing, Chen Linjiusheng, Cao Xuan, Advances in the extraction and pharmacological effects of total flavonoids in Chinese herbal medicines. MEDS Chinese Medicine (2025) Vol. 7: 26-31. DOI: http://dx.doi.org/10.23977/medcm.2025.070203.
REFERENCES
[1] Yao S. X.. Chemistry of natural products. Beijing: People's Health Publishing House, 2002.
[2] XU Ning, ZHANG Feng, XIAO Yuansheng, ZHANG Hua, LIANG Xinmiao. Flavonoids in Traditional Chinese Medicine[J]. University Chemistry,2010,25(S1):105-108.
[3] CHANU N R,GOGOI P,BARBHUIYA P A,et al.natural flavonoids as potential therapeutics in the manage ment of diabetic wound: A review[J]. Current Topics in Medicinal Chemistry. 2023,23(8):690-710.
[4] Li Mengru, Zhou Yuzhi, Du Guanhua, et al. Progress in the study of anti-aging effects of flavonoids in traditional Chinese medicine and their mechanisms[J]. Journal of Pharmacy,2019,54(8):1382-1391.
[5] Li Hui. Anti-inflammatory activity and anti-inflammatory/antioxidant cotransport mechanism of flavonoids based on the regulation of NF-κB signaling pathway[D]. Wuhan:Huazhong Agricultural University,2019.
[6] Johari J, Kianmehr A, Mustafa M R, et al. An tiviral activity of baicalein and quercetin against the Japa nese encephalitis virus[J]. Int J Mol Sci,2012 ,13(12):16785-16795.
[7] Wang Zheyuan, Zhang Lu, Zhang Youcheng. Research on anti-tumor mechanism of natural flavonoids[J]. Western Chinese Medicine, 2018,31: 138-142.
[8] Zhang L, Yang X, Cao Y, Gao WY. Study on the water extraction and purification process of total flavonoids from hawthorn leaves[J]. Food Research and Development,2010,31(01):12-16.
[9] Cao Dongmei, Cui Wenping, Zhang Dongjie. Research on the extraction method of flavonoids from Ghost Needlewort [J]. Journal of Heilongjiang Bayi Agricultural Reclamation University,2004,(02):76-79.
[10] LIU Cun-Fang, WEI Ling-Ling, WU Rui, LIU Quan, CAO Xiao-Yan, TIAN Guang-Hui. Ultrasonic extraction and bioactivity of flavonoids from the stem and leaf roots of Chrysanthemum officinale[J]. Chinese Journal of Traditional Chinese Medicine,2022,40(07):198-203.
[11] Yu Hai, Tao Bingying, Zhang Liqi. Extraction of flavonoids and terpene lactones from Ginkgo biloba by supercritical extraction[J]. Journal of Nanchang University(Engineering),2000,(04):34-38.
[12] WANG Yuan, XU Xin, LI Jiachuan. In vivo and ex vivo antioxidant activities of flavonoids from Garcinia Cambogia, a medicinal food resource of Tujia[J]. Food Science and Technology,2020,45(01):274-279.
[13] Lv Na, Zhang Weizhen, Chen Linlong, Zhang Jie, Shen Minghao. In vitro experimental study on the antioxidant activity of flavonoids in Anji white tea[J]. Journal of Toxicology,2014,28(05):389-392.
[14] Ma YJ, Shang YY, Wang DJ, et al. Neuroprotective effects of flavonoids extracted from the leaves of Diospyros kakiin D galactose induced aging mice by attenuating oxidative stress and neuroinflammation [J].Fudan Univ J Med Sci (Fudan Journal of Medicine),2015, 42: 7-12, 30.
[15] Wang SJ. Research on chemical composition, purification process and pharmacological activity of flavonoids from Ailanthus ailanthus[D]. Hubei:Hubei University of Traditional Chinese Medicine,2019.
[16] Chen Jiaxin. Mechanism of action of pearl plum flavonoid nanoparticles in inhibiting hepatocellular carcinoma cell proliferation through BTF3 regulation of HIF-1α ubiquitination[D]. Yanbian:Yanbian University,2024.
[17] Gao J,Morgan WA, Sanchez-Medina A, et al. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle ar rest and apoptosis including upregulation of p53 and Bax in human lung cancer cells[J]. Toxicology and Applied Pharmacology,2011,254 (3):221 -228.
[18] Zandi K, Teoh B T, Sam S S, et al. Novel antiviral activity of baicalein against dengue virus[J]. BMC Com plement Altern Med,2012,12:214.
[19] Khandelwal N, Chander Y, Kumar R, et al. Antiviral activity of apigenin against buffalopox:novel mechanistic insights and drug-resistance considerations[J].Antiviral Res,2020,181:104870.
[20] Yan W.-T. Purification of total flavonoids from C. jinshi and their antioxidant effects in vivo[D]. Harbin: Heilongjiang University of Traditional Chinese Medicine,2016.
[21] Dong LJ,Tian DY. Study on the nitrite scavenging ability of bamboo leaf flavonoids with metal ion complexes[J]. Food Science and Technology,2014,39(07):215-218.
[22] Lai Xin, Chen Qibing. Progress in the study of chemical composition and physiological function of bamboo leaf extract [J]. Fujian Forestry Science and Technology,2013,40(01):214-220+226.
[23] Zhang Hanghang. HPLC-IMS analysis and tyrosinase inhibitory activity of chemical components in licorice and safflower[D]. Aral: Tarim University,2020.
[24] Qi Xin. Study on the effect of soybean isoflavone extract from Korean dashi on apoptosis of breast cancer cells[D]. Yanbian: Yanbian University, 2019.
[25] YU Xiaoyi, CHANG Chang, CHEN Tianxiao, et al. Improvement of intestinal flora disorders and renal lipid deposition in mice with diabetic nephropathy by flavonoid glycosides from Wang Bu Liu Xing[J]. West China Journal of Pharmacy,2024,39(1):36-42.
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