A case report of NUT cancer in nasal sinus
DOI: 10.23977/tranc.2025.060101 | Downloads: 3 | Views: 156
Author(s)
Jinyan Chen 1, Guomin Li 2, Jianhao Yan 1
Affiliation(s)
1 The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510317, China
2 Guangdong Second Provincial General Hospital, Jinan University, Guangzhou, Guangdong, 510317, China
Corresponding Author
Jianhao YanABSTRACT
Uclear protein in testis (NUT) carcinoma is a rare, aggressive, poorly differentiated squamous cell carcinoma caused by NUT gene rearrangement on chromosome 15. Because it occurs in the middle line structure of the head and neck and the chest, it is also known as midline cancer. These tumors favor midline and quasi-midline structures in the upper digestive tract and mediastinum and can affect patients of a wide age range, including children.
KEYWORDS
NUT carcinoma, testis nuclear protein, squamous cell carcinomaCITE THIS PAPER
Jinyan Chen, Guomin Li, Jianhao Yan, A case report of NUT cancer in nasal sinus. Transactions on Cancer (2025) Vol. 6: 1-6. DOI: http://dx.doi.org/10.23977/tranc.2025.060101.
REFERENCES
[1] Huang, Q.W., et al., An Overview of Molecular Mechanism, Clinicopathological Factors, and Treatment in NUT Carcinoma. Biomed Res Int, 2019. 2019: p. 1018439.
[2] Sholl, L.M., et al., Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations. J Thorac Oncol, 2015. 10(6): p. 951-959.
[3] Bishop, J.A., C.A. French, and S.Z. Ali, Cytopathologic features of NUT midline carcinoma: A series of 26 specimens from 13 patients. Cancer Cytopathol, 2016. 124(12): p. 901-908.
[4] Shehata, B.M., et al., NUT midline carcinoma in a newborn with multiorgan disseminated tumor and a 2-year-old with a pancreatic/hepatic primary. Pediatr Dev Pathol, 2010. 13(6): p. 481-495.
[5] French, C.A., et al., Midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol, 2004. 22(20): p. 4135-4149.
[6] Ziai, J., C.A. French, and E. Zambrano, NUT gene rearrangement in a poorly-differentiated carcinoma of the submandibular gland. Head Neck Pathol, 2010. 4(2): p. 163-168.
[7] Mertens, F., et al., Successful treatment of a child with t (15; 19)-positive tumor. Pediatr Blood Cancer, 2007. 49(7): p. 1015-1027.
[8] Travis, W.D., et al., The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification. J Thorac Oncol, 2015. 10(9): p. 1243-1260.
[9] Stelow, E.B. and C.A. French, Carcinomas of the upper aerodigestive tract with rearrangement of the nuclear protein of the testis (NUT) gene (NUT midline carcinomas). Adv Anat Pathol, 2009. 16(2): p. 92-106.
[10] Shah, A.A., S.K. Jeffus, and E.B. Stelow, Squamous cell carcinoma variants of the upper aerodigestive tract: a comprehensive review with a focus on genetic alterations. Arch Pathol Lab Med, 2014. 138(6): p. 731-744.
[11] Bauer, D.E., et al., Clinicopathologic features and long-term outcomes of NUT midline carcinoma. Clin Cancer Res, 2012. 18(20): p. 5773-5789.
[12] Napolitano, M., et al., NUT midline carcinoma of the head and neck: current perspectives. Onco Targets Ther, 2019. 12: p. 3235-3244.
[13] Lauer, U.M., et al., NUT Carcinoma-An Underdiagnosed Malignancy. Front Oncol, 2022. 12: p. 914031.
[14] Scherman, N., et al., Possible Primary Thyroid Nuclear Protein in Testis Carcinomas with NSD3:NUTM1 Translocation Revealed by RNA Sequencing: A Report of Two Cases. Thyroid, 2022. 32(10): p. 1271-1276.
[15] Lemelle, L., et al., NUT carcinoma in children, adolescents and young adults. Bull Cancer, 2022. 109(4): p. 491-504.
[16] Chau, N.G., et al., An Anatomical Site and Genetic-Based Prognostic Model for Patients With Nuclear Protein in Testis (NUT) Midline Carcinoma: Analysis of 124 Patients. JNCI Cancer Spectr, 2020. 4(2): p. pkz094.
[17] Virarkar, M., et al., Clinical, Radiographic, Pathologic Characterization and Survival Outcomes of Nuclear Protein of the Testis Carcinoma. J Comput Assist Tomogr, 2021. 45(3): p. 431-441.
[18] Jimenez, C., et al., NUT carcinoma of the mandible in a child: case report and systematic review. Int J Oral Maxillofac Surg, 2023. 52(3): p. 304-312.
[19] Orman, G., et al., Pediatric thoracic mass lesions: Beyond the common. Eur J Radiol Open, 2020. 7: p. 100240.
[20] Chen, J., M. Li, and H. Lu, Nuclear protein in testis carcinoma of the lung. Transl Oncol, 2023. 30: p. 101640.
[21] Virarkar, M., et al., Imaging spectrum of NUT carcinomas. Clin Imaging, 2020. 67: p. 198-206.
[22] Lemelle, L., et al., NUT carcinoma in children and adults: A multicenter retrospective study. Pediatr Blood Cancer, 2017. 64(12).
[23] Chau, N.G., et al., Intensive treatment and survival outcomes in NUT midline carcinoma of the head and neck. Cancer, 2016. 122(23): p. 3632-3640.
[24] Lemelle, L., et al., NUT Carcinoma in Children and Adolescents: The Expert European Standard Clinical Practice Harmonized Recommendations. J Pediatr Hematol Oncol, 2023. 45(4): p. 165-173.
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