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  4. Vol 5, Issue 5, 2024

Progress in the study of drug-induced liver damage

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DOI: 10.23977/medsc.2024.050511 | Downloads: 9 | Views: 241

Author(s)

Yijing Yang 1, Yanping Shi 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Xi'an Children's Hospital, Xi'an, Shaanxi, 710003, China

Corresponding Author

Yanping Shi

ABSTRACT

Drug metabolism or biotransformation is one of the most important functions of the liver, at the same time the drug itself or metabolites can also cause liver damage, the liver damage caused by drug-induced liver injury (drug-induced liverinjury (DILI)).DILI manifested as acute viral hepatitis symptoms, can be seen in the liver area, discomfort, loss of appetite, malaise, nausea, etc., and severe cases can even be seen in liver failure, bleeding tendency, cerebral encephalopathy and other symptoms. In severe cases, liver failure, haemorrhagic tendency and hepatic encephalopathy can be seen. [1] With the continuous increase of new drugs and the increase of clinical medication, the incidence of drug hepatitis is increasing year by year, especially the vigorous promotion of Chinese medicine, the promotion and development of combined Chinese and Western medicine, the continuous improvement of Chinese and Western medicine dosage forms, and the rise of health care, which further broaden the application of various types of medicines in the clinical treatment and health care, but the drug liver injury caused by the drug is commonplace in clinic and reported more and more, and has become a major cause of liver damage in clinical practice. However, drug-induced liver injury is common in clinical practice, and the number of reports is increasing, and it has become a common clinical disease. In this review, we will make a comprehensive summary of the studies on drug-induced liver injury in the past 10 years.

KEYWORDS

Hepatitis; Chronic; Pharmacological; Autoimmune

CITE THIS PAPER

Yijing Yang, Yanping Shi. Progress in the study of drug-induced liver damage. MEDS Clinical Medicine (2024) Vol. 5: 72-77. DOI: http://dx.doi.org/10.23977/medsc.2024.050511.

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