Author(s)

Hao Wanjiao ¹, Liu Man ¹, Wei Junxiu ¹, Wang Bing ¹, Song Jie ¹, Ren Xiaopang ¹

Affiliation(s)

¹ Department of Reproductive Medicine, Affiliated Hospital of Hebei University, Baoding, China

Corresponding Author

Ren Xiaopang

ABSTRACT

Nowadays, the incidence of cancer in women is increasing. As the main treatment of most tumors, chemotherapy often damages the ovarian function of women, causes premature ovarian failure (chemotherapy-induced premature ovarian failure, CIPOF) induced by chemotherapy, and results in loss of fertility. It has caused great harm to women's physical and mental health and caused a series of social problems. Therefore, the effective treatment of CIPOF has become the focus of medical research. Stem cells have become the focus of research because of their ability of multi-differentiation and self-replication. Scholars at home and abroad have applied dry and fine stem cells. Preliminary results have been obtained in the animal experiment of restoring ovarian function, which brings hope to the recovery of ovarian function and reproductive function in patients with CIPOF. The progress of mesenchymal stem cell therapy for CIPOF is reviewed.

KEYWORDS

Chemotherapy-induced premature ovarian failure; mesenchymal stem cells; bone marrow mesenchymal stem cells; adipose mesenchymal stem cells; umbilical cord mesenchymal stem cells

CITE THIS PAPER

Hao Wanjiao, Liu Man, Wei Junxiu, Wang Bing, Song Jie, Ren Xiaopang. Research Progress of Mesenchymal Stem Cells in the Treatment of Chemotherapy-induced Premature Ovarian Failure. MEDS Clinical Medicine (2024) Vol. 5: 61-66. DOI: http://dx.doi.org/10.23977/medsc.2024.050509.

REFERENCES

[1] Kugajeevan Vigneswaran MRCOG, Haitham Hamoda MD FRCOG. Hormone replacement therapy – Current recommendations[J]. Best Pract Res Clin Obstet Gynaecol. 2022, 81:8-21. 
[2] Serge Rozenberg MD, PhD (Obstetrician-Gynaecologist). Menopausal hormone therapy and breast cancer risk [J]. Best Practice & Research Clinical Endocrinology & Metabolism. 2021, 35(6):101577. 
[3] Chen Y, Qian H, Zhu W, et al. Hepatocyte growth factor modidication promotes the melioration effects of human umbilical cord mesenchymal stem cell on rat acute kidney injury[J]. Stem Cells Dev, 2011, 20(1):103-113. 
[4] Meiling Yang, Li Lin, Chunli Sha, et al. Bone marrow mesenchymal stem cell-derived exosomal miR-144-5p improves rat ovarian function after chemotherapy-induced ovarian failure by targeting PTEN[J]. Lab Invest, 2020, 100(3): 342-352. 
[5] Bo Sun, Yujia Ma, Fang Wang, et al. miR-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis [J]. Stem Cell Res Ther. 2019; 10: 360. 
[6] Yuji Takehara, Akiko Yabuuchi, Kenji Ezoe. The restorative effects of adipose-derived mesenchymal stem cells on damaged ovarian function[J]. Lab Invest, 2013, 93(2):181-193. 
[7] Narges Nouri, Leili Aghebati-Maleki, Mehdi Yousefi. Adipose-Derived Mesenchymal Stem Cells: A Promising Tool in the Treatment of pre mature ovarian failure [J]. Reprod Immunol. 2021:147:103363. 
[8] Jing He, Chunchun Ao, Mao Li, Taoran Deng, et al. Clusterin-carrying extracellular vesicles derived from human umbilical cord mesenchymal stem cells restore the ovarian function of premature ovarian failure mice through activating the PI3K/AKT pathway[J]. Stem Cell Res Ther, 2024, 15(1):300. 
[9] Na Yin, Chao Luo, Lun Wei, et al. The mechanisms of MicroRNA 21 in premature ovarian insufficiency mice with mesenchymal stem cells transplantation: The involved molecular and immunological mechanisms[J]. Ovarian Res. 2024, 17(1):75. 
[10] Meiliang Zhang, Tingting Xie, Weiyou Dai, et al. Umbilical Cord Mesenchymal Stem Cells Ameliorate Premature Ovarian Insufficiency in Rats[J]. Evid Based Complement Alternat Med. 2022:9228456. 
[11] Xiaodan Lv, Chunyi Guan, Ying Li. Effects of single and multiple transplantations of human umbilical cord mesenchymal stem cells on the recovery of ovarian function in the treatment of premature ovarian failure in mice[J]. Ovarian Res. 2021:14(1):119. 
[12] Hongxing Li, Wei Zhao, Li Wang, et al. Human placenta-derived mesenchymal stem cells inhibit apoptosis of granulosa cells induced by IRE1α pathway in autoimmune POF mice[J]. Cell Biol Int. 2019 Aug; 43(8):899-909. 
[13] He Yantao, Liu Chaoqun, Hou Qiaoni, et al. Effects of hum an placenta mesenchym alstem celltransplantati On on superoxide dismutase 1 and uncoupling protein-2 in the treatment of premature ovarian failure in rats [J]. Chin J Reprod Contracep, 2018, 38(2)101-108. 
[14] Rongxia Liu, Xiaoyu Zhang, Zhenhai Fan. Human amniotic mesenchymal stem cells improve the follicular microenvironment to recover ovarian function in premature ovarian failure mice[J]. Stem Cell Res Ther. 2019, 10(1): 299-313. 
[15] Jun Li, Qingtong Yu, Haisen Huang. Human chorionic plate-derived mesenchymal stem cells transplantation restores ovarian function in a chemotherapy-induced mouse model of premature ovarian failure[J]. Stem Cell Res Ther. 2018, 9(1):81-90. 
[16] Fengyi Guo, Tian Xia, Yedan Zhang. Menstrual blood derived mesenchymal stem cells combined with Bushen Tiaochong recipe improved chemotherapy-induced premature ovarian failure in mice by inhibiting GADD45b expression in the cell cycle pathway[J]. Reprod Biol Endocrinol. 2019, 17(1):56. 
[17] Hao Xu, Xiaoyu Mao, Zhentao Nie, et al. Oxr1a prevents the premature ovarian failure by regulating oxidative stress and mitochondrial function in zebrafish [J]. Free Radic Biol Med, 2023 Jul: 203: 102-113. 
[18] Lin L, Gao W, Chen Y, et al. Reactive oxygen species-induced SIAH1 promotes granulosa cells' senescence in premature ovarian failure[J]. J Cell Mol Med. 2022; 26(8):2417-2427. 
[19] Boxian Huang, Chunfeng Qian, Chenyue Ding, et al. Fetal liver mesenchymal stem cells restore ovarian function in premature ovarian insufficiency by targeting MT1[J]. Stem Cell Res Ther. 2019, 10(1): 362. 
[20] Hongxia Xu, Xiuming Bao, Hanxin Kong, et al. Melatonin Protects Against Cyclophosphamide-induced Premature Ovarian Failure in Rats [J]. Hum Exp Toxicol. 2022, c: 41:9603271221127430. 
[21] Wang XW, Zhan Q, Coursen JD, et al. GADD45 induction of a G2/M cell cycle checkpoint[J]. Proc Natl Acad Sci U S A. 1999, 96(7):3706–3711. 
[22] Zhongrui Yan, Fengyi Guo, Qing Yuan. Endometrial mesenchymal stem cells isolated from menstrual blood repaired epirubicin-induced damage to human ovarian granulosa cells by inhibiting the expression of Gadd45b in cell cycle pathway[J]. Stem Cell Res Ther. 2019, 10(1):4
[23] Gittens JE, Barr KJ, Vanderhyden BC, et al. Interplay between paracrine signaling and gap junctional communication in ovarian follicles[J]. Cell Sci. 2005, 118(1):113–122. 
[24] Krysko DV, Mussche S, Leybaert L, et al. Gap junctional communication and connexin43 expression in relation to apoptotic cell death and survival of granulosa cells[J]. Histochem Cytochem. 2004, 52(9):1199–1207. 
[25] Song D., Zhong Y., Qian C., et al. Human umbilical cord mesenchymal stem cells therapy in cyclophosphamide-induced premature ovarian failure rat model[J]. BioMed Research International. 2016:2517514 
[26] Chaves R. N., Alves A. M. C. V., Lima L. F., et al. Role of nerve growth factor (NGF) and its receptors in folliculogenesis [J]. Zygote. 2013, 21(2):187–197. 
[27] Qun Zheng, Xiaoyan Fu, Jinzhan Jiang, etal. Umbilical Cord Mesenchymal Stem Cell Transplantation Prevents Chemotherapy-Induced Ovarian Failure via the NGF/TrkA Pathway in Rats[J]. Biomed Res Int. 2019, 2019: 6539294
[28] John G. B., Shidler M. J., Besmer P., et al. Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation[J]. Developmental Biology. 2009, 331(2):292–299. 
[29] Taoran Deng, Jing He, Qingyun Yao, et al. Human Umbilical Cord Mesenchymal Stem Cells Improve Ovarian Function in Chemotherapy-Induced Premature Ovarian Failure Mice Through Inhibiting Apoptosis and Inflammation via a Paracrine Mechanism[J]. Reproductive Sciences. 2021, 28(6):1718–1732. 
[30] Yating Huang, Qiuwan Zhang, Wenjiao Cao, et al. TNF-α and IFN-γ prestimulation enhances the therapeutic efficacy of human amniotic epithelial stem cells in chemotherapy-induced ovarian dysfunction [J]. Inflamm Regen. 2023; 43(1): 57-72. 

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