Author(s)

Chaoyuan Yang ¹, Xiujuan He ¹, Yaqin Wang ¹, Bowei Jiang ¹, Yongfu Tang ¹, Jiaguo Liang ¹, Wenjin Huang ¹, Linfeng Zhong ¹, Zukang Deng ¹, Shikang Huang ¹, Oufei Huang ²

Affiliation(s)

¹ College of Clinical Medical, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China
² Guangxi Yunqiu Biotechnology Co., Ltd, Nanning, Guangxi, 530000, China

Corresponding Author

Oufei Huang

ABSTRACT

Comparative Experimental Study on the Effects of Sweet Tea and Shutangbao on the Activities of α-Secretase and γ-Secretase and the Cognitive Memory Function in Mice Exposed to Aluminium Maltol. Sixty KM mice (with each body weight ranging from 30 to 35g) were divided into the control group, the model group, treatment group 1, and treatment group 2. Mice except the control were exposed to aluminium maltol for modeling. Treatment groups were treated with sweet tea and Shutangbao. Water maze tests were done in 3 stages. Subsequently, brain homogenates were prepared to measure enzyme activities. The results showed significant differences in water maze tests between the exposed groups and the normal group. During the modeling process, it was found that the level of α - secretase was reduced. Treatment improved enzyme expressions and cognitive memory of exposed mice. The animal model caused by the exposure of mice to aluminium maltol can affect the expressions of α - secretase and γ - secretase, thereby decreasing the cognitive memory ability. Sweet tea and Shutangbao can promote the increase in the expression levels of α-secretase and γ-secretase in mice exposed to aluminium maltol, and have an improving effect on the cognitive memory ability of the exposed mice.

KEYWORDS

Subchronic aluminum-exposed mice; Sweet Tea; Shuganbao; α-secretase, γ-secretase

CITE THIS PAPER

Chaoyuan Yang, Xiujuan He, Yaqin Wang, Bowei Jiang, Yongfu Tang, Jiaguo Liang, Wenjin Huang, Linfeng Zhong, Zukang Deng, Shikang Huang,  Oufei Huang. Comparative Experimental Study on the Effects of Sweet Tea and Shutangbao on the Activities of α-secretase and γ-secretase in Mice Poisoned by Aluminum Maltol. MEDS Clinical Medicine (2024) Vol. 5: 29-34. DOI: http://dx.doi.org/10.23977/medsc.2024.050505.

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