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  4. Vol 4, Issue 3, 2024

Research progress of TLR4/NF-κB pathway in the pathogenesis of rheumatoid arthritis

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DOI: 10.23977/phpm.2024.040301 | Downloads: 11 | Views: 332

Author(s)

Nan Yiyang 1, Cai Lili 1, Zhang Hongyun 1, Huang Xiaoxuan 1

Affiliation(s)

1 Guangzhou Special Service Convalescent Center of Rocket Force, Guangzhou, 510080, China

Corresponding Author

Nan Yiyang

ABSTRACT

Rheumatoid arthritis is a common autoimmune disease, and its complex pathogenesis remains inadequately understood. The TLR4/NF-κB pathway serves as a key regulatory pathway for inflammatory responses and plays an important role in the onset of rheumatoid arthritis. This article summarizes and analyzes the structure and function of the TLR4/NF-κB pathway, as well as how it influences the clinical manifestations of rheumatoid arthritis by mediating the production and release of inflammatory factors. The study explores the latest research progress regarding the correlation between the TLR4/NF-κB pathway and the pathogenesis of rheumatoid arthritis, while also discussing the potential and challenges of targeting this pathway for treatment. 

KEYWORDS

Rheumatoid arthritis; TLR4/NF-κB pathway; inflammatory response; clinical manifestations; therapeutic targets

CITE THIS PAPER

Nan Yiyang, Cai Lili, Zhang Hongyun, Huang Xiaoxuan, Research progress of TLR4/NF-κB pathway in the pathogenesis of rheumatoid arthritis. MEDS Public Health and Preventive Medicine (2024) Vol. 4: 1-5. DOI: http://dx.doi.org/10.23977/phpm.2024.040301.

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