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  4. Vol 5, Issue 1, 2024

The Effect of Fisetin on Human Triple Negative Breast Cancer Cell Line MDA-MB-231

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DOI: 10.23977/tranc.2024.050115 | Downloads: 21 | Views: 397

Author(s)

Zhimei Huang 1, Yu Luo 1, Xiuli Liu 2

Affiliation(s)

1 Guangxi Clinical Medical Research Center for Neurological Diseases, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China
2 Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China

Corresponding Author

Yu Luo

ABSTRACT

This study selected Fisetin as an intervention drug, and took human triple negative breast cancer (TNBC) cell line MDA-MB-231 as the experimental object to explore the effects of Fisetin on the proliferation, migration and invasion of MDA-MB-231 cells. The effect of Fisetin on cell activity was determined by CCK8 assay and the drug concentration was determined. The effect of Fisetin on cell proliferation ability was determined by EDU staining and plate clone formation assay. The effect of Fisetin on cell migration and invasion was determined by Transwell assay. Through CCK8, EDU staining, and plate clone formation experiments, we found that the vitality and proliferation ability of MDA-MB-231 cells were significantly weakened. Through Transwell experiments, we found that the migration and invasion ability of MDA-MB-231 cells significantly decreased. Therefore, Fisetin can effectively inhibit the proliferation, migration, and invasion of MDA-MB-231 cells.

KEYWORDS

Triple-negative breast cancer (TNBC), MDA-MB-231, Fisetin, proliferation, migration, invasion

CITE THIS PAPER

Zhimei Huang, Yu Luo, Xiuli Liu, The Effect of Fisetin on Human Triple Negative Breast Cancer Cell Line MDA-MB-231. Transactions on Cancer (2024) Vol. 5: 112-118. DOI: http://dx.doi.org/10.23977/tranc.2024.050115.

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