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  4. Vol 5, Issue 1, 2024

Research Progress in the Treatment of Prostate Cancer with Single Drug Extracts: A Meta-analysis

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DOI: 10.23977/tranc.2024.050114 | Downloads: 12 | Views: 519

Author(s)

Zhao Pengfei 1, Luo Xiangning 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China
2 Shaanxi University of Chinese Medicine Hospital, Xianyang, Shaanxi, China

Corresponding Author

Luo Xiangning

ABSTRACT

Prostate cancer one of the most common malignant tumors in elderly men, has occupied a major position in the diseases that threaten the health of middle-aged and elderly men, and its mortality rate ranks second among male tumors. It is found that traditional Chinese medicine plays an important role in the treatment of prostate cancer. This article reviews the research progress of traditional Chinese medicine extracts in the treatment of prostate cancer in recent years. Through the analysis of the etiology and pathogenesis of prostate cancer in Chinese medicine, the extracts of Chinese medicine (Polyphyllin I, PolyphyllinVII, PP7), glycyrrhizin, glycyrrhizin, licorice extract (glycyrrhetinic acid, glycyrrhizin, glycyrrhizin, etc.), baicalin extract (baicalin, baicalin, etc.), triptolide extract (triptolide, triptolide, etc.) and cantharidin extract (norcantharidin, etc.) in the treatment of prostate cancer are summarized and summarized, which reflects the advantages of traditional Chinese medicine in the treatment of prostate cancer. It is expected to provide a certain basis for the experimental research and clinical practice of traditional Chinese medicine in the treatment of prostate cancer, and lay a solid foundation for further exploration.

KEYWORDS

Prostate cancer; traditional Chinese medicine; extractive

CITE THIS PAPER

Zhao Pengfei, Luo Xiangning, Research Progress in the Treatment of Prostate Cancer with Single Drug Extracts: A Meta-analysis. Transactions on Cancer (2024) Vol. 5: 104-111. DOI: http://dx.doi.org/10.23977/tranc.2024.050114.

REFERENCES

[1] Min Shuhui, Hu Yi, Guo Ruiqi, etc. Analysis of disease burden and trend prediction of Prostate Cancer in China from 1990-2019 [J / OL]. Chinese tumors: 1-7 [2022-10-28]
[2] Lu Xin, Jiang Dongming, Hu Ming, et al. Prevalence characteristics and temporal trends of prostate cancer mortality in 2004-2018 [J]. Shanghai Preventive Medicine, 2021, 33 (10): 899-904 + 912.
[3] Tang Zhe, Zhu Jingyu. Progress in the adverse effects associated with androgen deprivation therapy in prostate cancer [J]. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2023, 33 (09): 879-882.
[4] Wang G, Zhao D, Spring DJ, De Pinho RA. Genetics and biology of prostate cancer. Genes Dev.2018 Sep 1; 32 (17-18):1105-1140.
[5] Wang Tao, Li Yubing, QiuDan Dan, etc. Exploration of modern TCM treatment strategies for prostate cancer [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2022, 39 (01)
[6] Mou Ruiyu, Li Xiaojiang, Jia Yingjie. Jia Yingjie experience in treating advanced prostate cancer [J]. Journal of Traditional Chinese Medicine, 2020, 61 (15)
[7] Yin Jie, Wang Xixing. Professor Wang Xixing has an experience in TCM treatment of prostate cancer [J]. Chinese Ethnic folk Medicine, 2018,27 (18): 72-73. 
[8] Liu Dong. Summary of Zhang Yaqin's experience in prostate cancer treatment [D]. Beijing University of Traditional Chinese Medicine, 2017.
[9] Niu Xiaofei, Wu Mingxin, Mou Weiyu, etc. Jia Yingjie's experience of " removing the treatment of prostate cancer [J]. Shaanxi Traditional Chinese Medicine, 2022,43 (01): 111-113 + 117.
[10] The National Pharmacopoeia Commission. Chinese Pharmacopoeia (Part I) [M]. Beijing: China Medical Science and Technology Press, 2020.
[11] Meng Wei, Du Juan, Chen Tao. Chemical composition of heavy buildings and its antitumor mechanisms [J]. Chemistry of Life, 2020,40 (01): 70-74.
[12] Liu Shuai, Zhang Denglu, Li Zhenyu. Chongfloor saponin V inhibited proliferation and cycle arrest in PC3 cells [J]. Journal of Nankai University (Natural Science Edition), 2020,53 (04): 88-92.
[13] Shen Zhengchao, Shen Jihong, Xie Xingxing, etc. Effect of Yunnan floor saponin on cell cycle and apoptosis in prostate cancer [J]. Journal of Modern Urology, 2021,26 (10): 867-872.
[14] Xia Chengxing. Effect and mechanism of total saponin in inhibiting the proliferation and invasion of prostate cancer cells [D]. Kunming Medical University, 2021.
[15] Liu Jiming. The proliferation inhibition of PP-26 on HCC HepG 2 cells [D]. Jinan University, 2017.
[16] Zou Peiliang, Zhang Qiuhong, Zhou Jianfu, etc. Molecular mechanism of barfloor saponin I inhibiting prostate cancer PC3 cell growth through the ERK / P65 / DNMT 1 pathway [J]. Chinese Journal, 2018, 24(03): 199-205. DOI: 10.13263/j.cnki.nja. 2018.03.002.
[17] Xiang Yuchen, Yang Rui, Zhou Tong, etc. Study of the mechanism by which collifloor saponin I is inhibiting prostate cancer metastasis through downregulation of the CIP2A / PP2A / ERK signaling pathway [J]. Journal of Hubei University of Medicine, 2019,38 (03): 201-208.
[18] Pei-Liang Z ,Qiu-Hong Z ,Jian-Fu Z , et al. [Inhibitory effect of polyphyllin Ⅰ on the proliferation of prostate cancer PC3 cells via ERK1/2/P65/DNMT1 and its molecular mechanism].[J]. National journal of andrology, 2018, 24(3).
[19] Xuewen L ,Zhiting S ,Jikun D , et al. Polyphyllin I inhibits invasion and epithelial-mesenchymal transition via CIP2A/PP2A/ERK signaling in prostate cancer.[J]. International journal of oncology,2018,53(3).
[20] Denglu Z ,Kailin L ,Chao S , et al. Anti-Cancer Effects of Paris Polyphylla Ethanol Extract by Inducing Cancer Cell Apoptosis and Cycle Arrest in Prostate Cancer Cells.[J]. Current urology,2018,11(3).
[21] Chen Zijun, Lu Shuli. "Lao" licorice: sweet taste, widely used [J]. Traditional Chinese medicine health regimen, 2022, 8 (04): 29-30.
[22] Xiao Xian, Li Chunyan, Liu Xiaolong, etc. Progress on the main chemical components and pharmacological effects of liquorice [J]. Journal of Xinxiang Medical College, 2023,40 (03): 280-285.
[23] Lu Ting. 18 β -glycyrrhetinic acid synergizes with enzalomide by inhibiting OATP2B1 uptake against castration-resistant prostate cancer [D]. Nanchang University, 2023.
[24] Yang Boya, Zhao Ruining, Wang Zhenwei, etc. Inhibition of the PI3K / AKT / AR pathway by licorice saccharin induces apoptosis in human prostate cancer C4-2B cells [J]. Journal of Ningxia Medical University, 2022,44 (03): 228-233.
[25] Wang Xuefeng, Zhao Qi. Licorin inhibits PC3 cell growth in human prostate cancer [J]. Journal of Clinical and Pathology, 2018,38 (11): 2308-2313.
[26] Chen Fu, Xu Houqiang, Duan Zhiqiang and so on. Glycyrrhetinic acid regulates the transcription of BLM and the proliferation, apoptosis and migration and invasion of PC3 cells [J]. Biotech, 2017,27 (03): 282-288.
[27] Fengyan Z, Fufang W, Wenjie L, et al. The toxicity mechanism of glabridin in prostate cancer cells is involved in reactive oxygen species-dependent PI3K/Akt pathway: Integrated utilization of bioinformatic analysis and in vitro test validation.[J]. Environmental toxicology,2022,37(12).
[28] Katerina G,Anastasia P,Dimitra B, et al. Glycyrrhiza glabra -Enhanced Extract and Adriamycin Antiproliferative Effect on PC-3 Prostate Cancer Cells.[J]. Nutrition and cancer,2020,72(2).
[29] You S,Pramod A,Mingyue J, et al. Correction to: Transcriptional suppression of androgen receptor by 18β-glycyrrhetinic acid in LNCaP human prostate cancer cells.[J]. Archives of pharmacal research,2020,43(8).
[30] Changbao C,Rui S,Bin L, et al. Neoisoliquiritin exerts tumor suppressive effects on prostate cancer by repressing androgen receptor activity[J]. Phytomedicine,2021,85.
[31] Li Jinjin, Ma Huagen, Qu Huihua, etc. Based on the processing theory of traditional Chinese medicine, the clinical application of different Scutellaria baicalensis products [J / OL]. Journal of Liaoning University of Traditional Chinese Medicine: 1-8 [2023-10-07].
[32] Long Gongwei, Ye Tianrun, Zhang Yucong, etc. Network pharmacological analysis of the antiprostate cancer effects of Scutellaria baicalensis [J]. Modern Journal of Genitourinary Oncology, 2021,13 (05): 284-290 + 297.
[33] Tang Zhao, Yu Qinnan, Zhu Feng, etc. Ininhibitory effect of baicalin on proliferation and invasion and mechanism of prostate cancer cells [J]. New Traditional Chinese Medicine, 2021,53 (16): 127-131.
[34] Liang Kun, Wang Lu. Baicalin inhibits the proliferation of prostate cancer cells by upregulating the expression of miR-485-5p [J]. Chinese Journal of Hospital Pharmacy, 2018,38 (17): 1812-1815 + 1822.
[35] Yang Ning, Wang Ling, Luo Zhigang. The hibition and mechanism of Baicalein on proliferation and invasion of PC-3 cells in human prostate cancer [J]. Guangdong Medicine, 2016,37 (15): 2238-2241.
[36] MingHui W,Kun W,YuanBing Z, et al. Baicalin Antagonizes Prostate Cancer Stemness via Inhibiting Notch1/NF-κB Signaling Pathway.[J]. Chinese journal of integrative medicine,2023.
[37] Yuening S,Wenjing G,Yongjian G, et al. Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network[J]. Food and Chemical Toxicology,2022,169.
[38] Ziqiang Y,Changsheng Z,Hexi D, et al. Baicalin suppresses the cell cycle progression and proliferation of prostate cancer cells through the CDK6/FOXM1 axis.[J]. Molecular and cellular biochemistry,2020,469(1).
[39] C S M,R C,N T Y, et al. Baicalein inhibits the proliferative activity of human prostate cancer cell line PC3 by downregulating Ezrin.[J]. Journal of biological regulators and homeostatic agents,2020,34(3).
[40] Can W,Junfeng J,Yanbin Z, et al. Wogonoside Inhibits Prostate Cancer Cell Growth and Metastasis via Regulating Wnt/β-Catenin Pathway and Epithelial-Mesenchymal Transition.[J]. Pharmacology,2019,104(5-6).
[41] Zhang Xueling, Li Na, Chen Li. Progress in antitumor derivatives of Triptolidin [J / OL]. Journal of China Pharmaceutical University: 1-11 [2023-10-07].
[42] Lang Xiaoxue, Xue Jianqiao, Fu Jing, etc. Progress in the antitumor effects of triptolide and its nanopreparations [J]. China Journal of New Drugs, 2023,32 (09): 893-901.
[43] Zhang Junqiang, Wan Jiukai, Yao Haoyu, etc. Inhibition of triptolide on prostate cancer cells via the miR-320bAR axis [J]. Northwest Journal of Pharmacy, 2022,37 (01): 65-70.
[44] Sun Qiang, Wang Kefeng, Fei Xiang, etc. The influence and mechanism of triptolide on the biological behavior of DU-145 cells in prostate cancer [J]. Progress in Anatomical Science, 2021,27 (02): 183-185 + 190.
[45] Meng Yuan. The mechanism of inhibiting bladder cancer by regulating ion transmembrane transport [D]. Jinzhou Medical University, 2022.
[46] Zeng Can, Wang Kebing, Cao Shijin. Analysis of triptolide-loaded exosome against mouse prostate cancer [J]. Chinese Journal of Comparative Medicine, 2020,30 (09): 49-53.
[47] Song Zhenguo, Zhao Pengcheng, Shao Qingping, etc. Experimental hibition of PC3 cells in castration-resistant prostate cancer [J]. Journal of Practical Cancer, 2018,33 (12): 1931-1934.
[48] Wang Lei, Gao Jing, Kang Shaosan, etc. Targeting of Th 17-IL-17 pathway to prevent minimally invasive prostate cancer in mouse [J]. Research and Practice of Modern Traditional Chinese Medicine, 2017,31(06):25-28. DOI:10. 13728/j. 1673-6427.2017.06.008.
[49] Arisan D E,Rencuzogullari O,Coban M, et al. The role of the PI3K/AKT/mTOR signaling axis in the decision of the celastrol-induced cell death mechanism related to the lipid regulatory pathway in prostate cancer cells[J]. Phytochemistry Letters,2020,39.
[50] Fulu D,Ping Y,Rui W, et al. Triptonide acts as a novel antiprostate cancer agent mainly through inhibition of mTOR signaling pathway.[J]. The Prostate,2019,79(11).
[51] Xia Miaofen, Zhou Shuanglin. The molecular mechanism study of spot pharmacology based on bioinformatics and systems pharmacology [J]. Traditional Chinese Medicine Guide, 2019,25 (20): 60-65.
[52] Yohko Y,Manabu K,Isao M. Deoxynortryptoquivaline: A unique antiprostate cancer agent.[J]. Oncology research, 2023, 31(6).
[53] Luo Xiangning, Wang Wenjuan, Li Kai, et al. Effect of desin on proliferation and apoptosis of PC-3 cells in androgen-independent prostate cancer [J]. Shaanxi Journal of Medicine, 2020,49 (08): 928-931 + 939.
[54] Luo Xiangning, Wang Wenjuan, Li Kai, et al. Effect of inhibitory expression of matrix metalloproteinase-9 protein on the migration and invasion of PC-3 cells in prostate cancer [J]. Chinese Journal of Integrated Traditional Chinese and Western Medicine Surgery, 2021,27 (05): 673-677.
[55] Luo Xiangning, Wang Wenjuan, Li Kai, et al. Inpressed expression of cortactin and MMP-9 and decreased invasion of PC-3 cells in prostate cancer [J]. Chinese Journal of Integrated Traditional Chinese and Western Medicine, 2022, 42 (06): 728-732.
[56] Lou Tiantian, Du Juan, Chen Xiangsheng, etc. Inhibition of porkinin on PC-3 cell proliferation in prostate cancer [J]. Journal of Mountain Agricultural Biology, 2014,33 (02): 61-63 + 68.
[57] Chen Sansan.Investigation of the effects of noresin on DU145 cells in hormone-independent prostate cancer [D]. Southern Medical University, 2013.
[58] Md U N, Honghua Y, Sang-Youel P. Downregulation of c FLIP and upregulation of DR 5 by cantharidin sensitizes TRAIL mediated apoptosis in prostate cancer cells via autophagy flux.[J]. International journal of molecular medicine, 2020, 46(1). 
[59] Lijun M,Xinji Z,Xiaojun S, et al. Norcantharidin enhances antitumor immunity of GM-CSF prostate cancer cells vaccine by inducing apoptosis of regulatory T cells.[J]. Cancer science,2018,109(7). 

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