Author(s)

Jingjing Ge ¹, Zhaobin Yu ¹, He Chen ¹

Affiliation(s)

¹ Clinical Laboratory Center, Maternal and Child Health Hospital of Qingyuan, Qingyuan, Guangdong, China

Corresponding Author

Jingjing Ge

ABSTRACT

This study focuses on the biological characteristics of CD169 and CD64 and their applications in infection diagnosis. CD169, the sialic acid receptor, plays an important role in immune response, participating in immune regulation and cell-cell interactions by recognizing and binding to pathogens that acidify. As a receptor for FC-γ, CD64 plays a key role in the immunoglobulin superfamily, mediating the phagocytosis of immune complexes and influencing immune responses. They interact in the immune response and enhance the immune effect together. Bacterial and viral detection methods, as well as the use of white blood cell count and C-reactive protein in the diagnosis of infection are also outlined, while the limitations of existing diagnostic methods are pointed out. In the application of CD169 and CD64, flow cytometry has become an important assay to quantify specific molecules on the cell surface and provide accurate information for infection diagnosis. Further study on the role of CD169 and CD64 in infection diagnosis is of great significance for improving the level of diagnosis and treatment.

KEYWORDS

CD169; CD64; Infectious diseases; Immune response; Flow cytometry

CITE THIS PAPER

Jingjing Ge, Zhaobin Yu, He Chen, Application of CD169, CD64 infection index in differential diagnosis of infectious diseases. MEDS Clinical Medicine (2024) Vol. 5: 51-56. DOI: http://dx.doi.org/10.23977/medsc.2024.050406.

REFERENCES

[1] Zhang Y X, Yang Q T, Zhang M X, et al. Expression and clinical value of nCD64 and mCD169 in patients with early acute infection [J]. International Journal of Laboratory Medicine, 2023, 44(20):2453-2456.
[2] Ikezumi Y , Kondo T , Matsumoto Y ,et al.Analysis of CD169 (Sialoadhesin)-Positive Activated Macrophages in Kidney Damage in Lupus Nephritis[J].Journal of the American Society of Nephrology, 2023, 34(11S):596.
[3] Klaas M , Dubock S , Ferguson D J P ,et al.Sialoadhesin (CD169/Siglec-1) is an extended molecule that escapes inhibitorycis-interactions and synergizes with other macrophage receptors to promote phagocytosis[J].Glycoconjugate Journal, 2023, 40(2):213-223.
[4] Zhang Xiaolin, Mao Qinghua, Ju Guanjun, et al. Relationship between CD64 index, sCD14, sCD163 and severe pulmonary infection after thoracoscopic radical resection of lung cancer [J]. Progress in Modern Biomedicine, 2024(002): 024.

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