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  4. Vol 5, Issue 3, 2024

The Mechanism and Treatment Research Progress of Metformin in Treating Endometriosis

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DOI: 10.23977/medsc.2024.050325 | Downloads: 13 | Views: 538

Author(s)

Fenxiu Cai 1,2, Qianyu Wang 1,2, Wenhong Hu 2

Affiliation(s)

1 Department of Gynecology, The Second Affiliated Hospital of Dali University, Kunming, Yunnan, China
2 School of Clinical Medicine, Dali University, Dali, Yunnan, China

Corresponding Author

Wenhong Hu

ABSTRACT

Endometriosis is a common disease in women of childbearing age, and its specific pathogenesis is not yet clear. The clinical pharmacological treatment mainly involves the continuous use of progestins, GnRH analogs, danazol, aromatase inhibitors, and other drugs. However, some studies have shown that various medications have limitations in their application for the treatment of endometriosis. Metformin is a widely used insulin sensitizer for treating type 2 diabetes. Due to its pleiotropic effects, metformin is now also applied in the treatment of endometriosis. It mainly works by activating the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway, inhibiting interleukin (IL)-1-mediated IL-8 secretion, and reducing the expression of the anti-apoptotic gene Bcl-2. Metformin's use in treating endometriosis has a unique mechanism of action, without serious side effects, making it an effective anti-inflammatory and anti-proliferative drug. This article aims to explore the mechanism of action of metformin in endometriosis and the possibility of drug treatment.

KEYWORDS

Endometriosis; Metformin; Mechanism; Side effects; Drug treatment

CITE THIS PAPER

Fenxiu Cai, Qianyu Wang, Wenhong Hu, The Mechanism and Treatment Research Progress of Metformin in Treating Endometriosis. MEDS Clinical Medicine (2024) Vol. 5: 166-173. DOI: http://dx.doi.org/10.23977/medsc.2024.050325.

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