Author(s)

Xianglu Tie ¹, Li Ren ²

Affiliation(s)

¹ Department of Clinical Medicine, Qinghai University, Xining, 810001, China
² Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining, 810001, China

Corresponding Author

Li Ren

ABSTRACT

Pancreatic ductal adenocarcinoma has the characteristics of rapid onset and poor prognosis. At present, how to improve the postoperative survival rate and long-term quality of life of patients is a difficult problem for hepatobiliary and pancreatic surgeons. Surgery is one of the main ways to treat pancreatic cancer. Postoperative infection of pancreatic cancer is frequent, which seriously reduces the postoperative quality of life and survival time of patients. This article reviews the related research progress in recent years, and discusses the related aspects of postoperative infection of pancreatic cancer, such as postoperative pulmonary infection, abdominal infection and incision infection. Through systematic analysis of relevant literature, the definition, category, diagnostic methods, preventive measures and treatment strategies of postoperative infection were sorted out, aiming to provide more practical reference for clinicians, so as to optimize patient management and improve treatment effect.

KEYWORDS

Pancreatic cancer, Postoperative infection, Research progress, Review

CITE THIS PAPER

Xianglu Tie, Li Ren, Research progress on postoperative infection of pancreatic cancer. MEDS Clinical Medicine (2024) Vol. 5: 118-122. DOI: http://dx.doi.org/10.23977/medsc.2024.050318.

REFERENCES

[1] Wang X, Cheng H, Liu C, et al. (2023) 2022 New advances in pancreatic cancer research and treatment. Chinese Journal of Cancer, 33(01): 1-13.
[2] GBD 2017 Pancreatic Cancer Collaborators.(2019)The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017 . Lancet Gastroenterol Hepatol, 4(12): 934-947.
[3] Bai R, Sun Bei.(2024)NCCN Clinical Practice Guidelines for Pancreatic Cancer (2023.V2) Update. Chinese Journal of Practical Surgery, 44(01): 85-88.
[4] General Office of National Health Commission.(2022)Pancreatic Cancer Clinical Practice Guidelines (2022.V2). Journal of Clinical Hepatobiliary Disease, 38(05): 1006-1030.
[5] Sugiura T, Uesaka K, Ohmagari N, et al. (2012)Risk factor of surgical site infection after pancreaticoduodenectomy. World J Surg, 36(12): 2888-2894.
[6] Barreto S G, Singh M K, Sharma S, et al. (2015)Determinants of Surgical Site Infections Following Pancreatoduodenectomy. World J Surg, 39(10): 2557-2563.
[7] Zhang L, Liao Q, Zhang T, et al. (2016)Blood Transfusion is an Independent Risk Factor for Postoperative Serious Infectious Complications after Pancreaticoduodenectomy. World J Surg, 40(10): 2507-2512.
[8] Shinkawa H, Takemura S, Uenishi T, et al. (2013) Nutritional risk index as an independent predictive factor for the development of surgical site infection after pancreaticoduodenectomy. Surg Today, 43(3): 276-283.
[9] LU Wenhui, LIU Yingbin, LIANG Tingbo, et al. (2017)Expert consensus on the diagnosis, treatment and prevention of common postoperative surgical complications after pancreatic surgery (2017). Journal of Concordant Medicine, 8(Z1): 139-146. 
[10] H. Zhang, H. Zhuang, H. Han, X. Yao, et al. (2016)The application of sighing cough training for effective sputum removal after partial hepatectomy for hepatocellular carcinoma. Shanxi Medical Journal, 45(22): 2645-2647.
[11] ZHAO Jiangqiao, YANG Jiaping, YANG Xinghou, et al.(2020)Analysis of risk factors for postoperative complication of lung infection in pancreatic cancer patients. Chinese Journal of Integrated Chinese and Western Medicine Surgery, 26(04): 646-649.
[12] WANG Y, ZHOU J S, XU X C, et al. (2018)Endoplasmic reticulum chaperone GRP78 mediates cigarette smoke-induced necroptosis and injury in bronchial epithelium. Int J Chron Obstruct Pulmon Dis, 13: 571-581.
[13] MAZUSKI J E, TESSIER J M, MAY A K, et al. (2017)The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection. Surg Infect (Larchmt), 18(1): 1-76.
[14] ZHANG Shuo, WANG Feng, SUN Kuisheng, et al.(2013) Relationship between the incidence of lung infection and smoking in patients with severe craniocerebral injury. Chinese Journal of Neurosurgical Diseases, 12(02): 175-176.
[15] Sundar I K, Rashid K, Sellix M T, et al. (2017)The nuclear receptor and clock gene REV-ERBα regulates cigarette smoke-induced lung inflammation. Biochem Biophys Res Commun, 493(4): 1390-1395.
[16] ZHANG Mingtu, XU Weiyun, TANG Qiufang, et al. (2014) Clinical study on the effect of different anesthesia methods on postoperative lung infection in elderly patients with duodenopancreatic head cancer. Chinese Journal of Hospital Infection, 24(24): 6177-8+84.
[17] Sawyer R G, Claridge J A, Nathens A B, et al. (2015)Trial of short-course antimicrobial therapy for intraabdominal infection . N Engl J Med, 372(21): 1996-2005.
[18] Pancreatic Surgery Group of the Chinese Medical Association Surgical Branch, Pancreatic Disease Specialized Committee of the Chinese Society of Research Hospitals, Editorial Board of the Chinese Journal of Surgery. (2017)Expert consensus on the diagnosis, treatment and prevention of common postoperative surgical complications after pancreatic surgery (2017). Chinese Journal of Surgery, 55(5): 328-334.
[19] Watkins R R, Lemonovich T L.(2012)Serum procalcitonin in the diagnosis and management of intra-abdominal infections. Expert Rev Anti Infect Ther, 10(2): 197-205.
[20] Wang Peiyu, Huang Qi, Wang Shaodong, et al. (2024) Interpretation of key points of Global Cancer Statistics 2022. Chinese Clinical Journal of Thoracic and Cardiovascular Surgery: 1-22.
[21] Carioli G, Malvezzi M, Bertuccio P, et al.(2021) European cancer mortality predictions for the year 2021 with focus on pancreatic and female lung cancer . Ann Oncol, 32(4): 478-487.
[22] Klein A P. (2021) Pancreatic cancer epidemiology: understanding the role of lifestyle and inherited risk factors. Nat Rev Gastroenterol Hepatol, 2021, 18(7): 493-502.

Sponsors, Associates, and Links

---

• Journal of Neurobiology and Genetics
  
  
• Medical Imaging and Nuclear Medicine
  
  
• Bacterial Genetics and Ecology
  
  
• Transactions on Cancer
  
  
• Journal of Biophysics and Ecology
  
  
• Journal of Animal Science and Veterinary
  
  
• Academic Journal of Biochemistry and Molecular Biology
  
  
• Transactions on Cell and Developmental Biology
  
  
• Rehabilitation Engineering & Assistive Technology
  
  
• Orthopaedics and Sports Medicine
  
  
• Hematology and Stem Cell
  
  
• Journal of Intelligent Informatics and Biomedical Engineering
  
  
• MEDS Basic Medicine
  
  
• MEDS Stomatology
  
  
• MEDS Public Health and Preventive Medicine
  
  
• MEDS Chinese Medicine
  
  
• Journal of Enzyme Engineering
  
  
• Advances in Industrial Pharmacy and Pharmaceutical Sciences
  
  
• Bacteriology and Microbiology
  
  
• Advances in Physiology and Pathophysiology
  
  
• Journal of Vision and Ophthalmology
  
  
• Frontiers of Obstetrics and Gynecology
  
  
• Digestive Disease and Diabetes
  
  
• Advances in Immunology and Vaccines
  
  
• Nanomedicine and Drug Delivery
  
  
• Cardiology and Vascular System
  
  
• Pediatrics and Child Health
  
  
• Journal of Reproductive Medicine and Contraception
  
  
• Journal of Respiratory and Lung Disease
  
  
• Journal of Bioinformatics and Biomedicine