Education, Science, Technology, Innovation and Life
Open Access
Sign In

Analysis of cognitive dysfunction and its influencing factors in patients with megaloblastic anemia

Download as PDF

DOI: 10.23977/medsc.2024.050311 | Downloads: 4 | Views: 118

Author(s)

Ji Qi 1, Yiyang Li 1, Lin Duan 1, Yankui Shi 1

Affiliation(s)

1 Laboratory Department, Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, China

Corresponding Author

Yiyang Li

ABSTRACT

The purpose of this paper is to explore the cognitive dysfunction and its influencing factors in patients with Megaloblastic Anemia (MA). Through descriptive statistical analysis, independent sample T test, correlation analysis and multiple regression analysis, the cognitive function of MA patients and the control group was compared. The results showed that the levels of folic acid and vitamin B12 in the patient group were significantly lower than those in the control group, and the scores of cognitive function evaluation were also low. Correlation analysis showed that the levels of folic acid and vitamin B12 were positively correlated with cognitive function. Multiple regression analysis further revealed that folic acid level was the most influential factor on cognitive function. This study reveals the possible mechanism of cognitive dysfunction in patients with MA, and emphasizes the importance of folic acid and vitamin B12 in maintaining normal cognitive function. At the same time, the study also pointed out the future research direction, including expanding the sample size and adopting more comprehensive evaluation methods, in order to explore the pathogenesis and influencing factors of cognitive dysfunction in MA patients.

KEYWORDS

Megaloblastic anemia; cognitive dysfunction; influencing factors

CITE THIS PAPER

Ji Qi, Yiyang Li, Lin Duan, Yankui Shi, Analysis of cognitive dysfunction and its influencing factors in patients with megaloblastic anemia. MEDS Clinical Medicine (2024) Vol. 5: 68-74. DOI: http://dx.doi.org/10.23977/medsc.2024.050311.

REFERENCES

[1] Ahrens-Nicklas, R. C., Ganetzky, R. D., Rush, P. W., Conway, R. L., & Ficicioglu, C. (2019). Characteristics and outcomes of patients with formiminoglutamic aciduria detected through newborn screening. Journal of Inherited Metabolic Disease, 42(1), 140-146.
[2] Chen, X., Zhou, Q., Zhang, T., Wang, C. X., & Huang, X. (2019). Development of a sensitive chemiluminescence immunoassay for the quantification of folic acid in human serum. Journal of Analytical Methods in Chemistry, 2019(4), 1-7.
[3] Avci, E., & Aslan, D. (2019). Determination of indirect reference intervals of vitamin b12 for outpatients admitted to primary healthcare centers. LaboratoriumsMedizin, 44(1), 11-16.
[4] Gokcebay, D. G., Tekgunduz, S. A., & Cavdarli, B. (2020). Imerslund-grsbeck syndrome presenting with microangiopathic hemolytic anemia in a child. European Journal of Medical Genetics, 63(6), 103880.
[5] Bain, B. J. (2010). Schistocytes in megaloblastic anemia. American Journal of Hematology, 85(8), 599.
[6] Mozzillo, E., Melis, D., Falco, M., Fattorusso, V., Taurisano, R., & Flanagan, S. E., et al. (2013). Thiamine responsive megaloblastic anemia: a novel slc19a2 compound heterozygous mutation in two siblings. Pediatric Diabetes, 14(5), 384-387.
[7] Siurala, M. (2009). Gastric lesion in some megaloblastic anemias. Acta Medica Scandinavica, 154(5), 337-348.
[8] nder, A., Bas, V., N., Yilmaz, & Agudioglu, et al. (2012). Thiamine-responsive megaloblastic anemia syndrome: a novel mutation. Genetic counseling, 23(2), 149-156.
[9] Oyake, T., Ito, S., Kowata, S., Murai, K., & Ishida, Y. (2005). Ineffective hematopoiesis in megaloblastic anemia is associated with higher frequency of apoptosis in each lineage immature and mature cells. Blood, 106(11), 3601-3601.
[10] Vuceli, V., Stanci, V., Ledinsky, M., Getaldi, B., & Carzavec, D. (2009). Combined megaloblastic and immunohemolytic anemia associated--a case report. Acta clinica Croatica, 47(4), 239-243.

Downloads: 5116
Visits: 236026

Sponsors, Associates, and Links


All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.