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Analysis of cognitive dysfunction and its influencing factors in patients with megaloblastic anemia

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DOI: 10.23977/medsc.2024.050311 | Downloads: 4 | Views: 118


Ji Qi 1, Yiyang Li 1, Lin Duan 1, Yankui Shi 1


1 Laboratory Department, Affiliated Hospital of Hebei University, Baoding, Hebei Province, 071000, China

Corresponding Author

Yiyang Li


The purpose of this paper is to explore the cognitive dysfunction and its influencing factors in patients with Megaloblastic Anemia (MA). Through descriptive statistical analysis, independent sample T test, correlation analysis and multiple regression analysis, the cognitive function of MA patients and the control group was compared. The results showed that the levels of folic acid and vitamin B12 in the patient group were significantly lower than those in the control group, and the scores of cognitive function evaluation were also low. Correlation analysis showed that the levels of folic acid and vitamin B12 were positively correlated with cognitive function. Multiple regression analysis further revealed that folic acid level was the most influential factor on cognitive function. This study reveals the possible mechanism of cognitive dysfunction in patients with MA, and emphasizes the importance of folic acid and vitamin B12 in maintaining normal cognitive function. At the same time, the study also pointed out the future research direction, including expanding the sample size and adopting more comprehensive evaluation methods, in order to explore the pathogenesis and influencing factors of cognitive dysfunction in MA patients.


Megaloblastic anemia; cognitive dysfunction; influencing factors


Ji Qi, Yiyang Li, Lin Duan, Yankui Shi, Analysis of cognitive dysfunction and its influencing factors in patients with megaloblastic anemia. MEDS Clinical Medicine (2024) Vol. 5: 68-74. DOI:


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