Author(s)

Huang Chongzong ¹

Affiliation(s)

¹ Zunyi Medical University, Zunyi, China

Corresponding Author

Huang Chongzong

ABSTRACT

REV-ERB receptor is a member of protein nuclear receptor superfamily, which is both intracellular receptor and transcription factor, so it regulates the expression of target gene. REV-ERB acts as a transcription inhibitor because of its unique structure. Their main function is to control the peripheral circadian rhythm by participating in the transcription-translation feedback loop with other major clock genes. As for their role in the pathogenesis of cancer, recent studies in various cancer tissues show that their expression is down-regulated in most cases. The imbalance of its expression is also related to cancer-related cachexia. The use of synthetic agonists can restore its pharmacological significance. Synthetic agonists have been explored in preclinical studies, but the data are scarce. It is necessary to further study, mainly through the mechanism study, the influence of REV-ERB-induced circadian rhythm disorder on carcinogenesis and cancer-related systemic effects (such as cachexia), in order to solve the potential problems of related therapeutic significance.

KEYWORDS

REV-ERB receptor, nuclear receptor, transcription factor, cancer

CITE THIS PAPER

Huang Chongzong, The role of Nr1d1 in tumor. Transactions on Cancer (2024) Vol. 5: 63-71. DOI: http://dx.doi.org/10.23977/tranc.2024.050109.

REFERENCES

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