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Advances in the diagnosis and treatment of liver injury in acute pancreatitis

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DOI: 10.23977/medsc.2024.050304 | Downloads: 4 | Views: 134

Author(s)

Yang Li 1, Xiaohong Zhang 2

Affiliation(s)

1 School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China
2 Department of Emergency, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China

Corresponding Author

Xiaohong Zhang

ABSTRACT

Acute pancreatitis, as a common acute abdominal disease, has a rapid onset and rapid development, and if not properly diagnosed and treated, it can easily lead to systemic inflammatory response syndrome and multi-organ dysfunction. In recent years, many studies have shown that liver damage is often combined with AP (Acute Pancreatitis) in the course of its development, and the degree of liver damage is closely related to the disease progression and severity of AP and affects its prognosis. Therefore, the diagnosis and treatment of LIAAP (Liver Injury Associated Acute Pancreatitis) is of great clinical significance for the comprehensive evaluation of patients' conditions and therapeutic effects. In this paper, we briefly review the progress of diagnosis and treatment of liver injury caused by acute pancreatitis.

KEYWORDS

Acute pancreatitis liver injury, diagnosis, treatment

CITE THIS PAPER

Yang Li, Xiaohong Zhang, Advances in the diagnosis and treatment of liver injury in acute pancreatitis. MEDS Clinical Medicine (2024) Vol. 5: 23-29. DOI: http://dx.doi.org/10.23977/medsc.2024.050304.

REFERENCES

[1] Liu W, Du JJ, Li ZH, Zhang XY, Zuo HD. Liver injury associated with acute pancreatitis: the current status of clinical evaluation and involved mechanisms. World J Clin Cases. 2021; 9(34):10418-10429. 
[2] Halonen KI, Pettilä V, Leppäniemi AK, Kemppainen EA, Puolakkainen PA, Haapiainen RK. Multiple organ dysfunction associated with severe acute pancreatitis. Crit Care Med 2002; 30: 1274- 1279 
[3] U. Barlass, R. Dutta, H. Cheema, J. George, A. Sareen, A. Dixit, Z. Yuan, B. Giri, J. Meng, S. Banerjee, S. Banerjee, V. Dudeja, R.K. Dawra, S. Roy, A.K. Saluja, Morphine worsens the severity and prevents pancreatic regeneration in mouse models of acute pancreatitis, Gut 67 (4) (2017) 600- 602.
[4] Hou S, Tang X, Cui H, Liu C, Bai X, Shi L, Shi Y. Fatty liver disease is associated with the severity of acute pancreatitis: a systematic review and meta- analysis. Int J Surg 2019; 65: 147-153 
[5] Wang X, Zhao X, Shi C, et al. Potential mechanisms and significance of acute pancreatitis-associated liver injury. Scand J Gastroenterol. 2006;41(5 ):604-613. 
[6] GUI Y, SUN JJ, YANG YH, et al. Effect of bilateral greater splanchnic nerve transection on hepatic injury in dogs with acute necrotizing pancreatitis [J]. J Clin Hepatol, 2018, 34 (8): 1733 - 1739.
[7] YANG Y, HAN CY, GUAN QB, et al. Interleukin -17 - mediated inflammation promotes nonalcoholic fatty liver disease in mice with regulation of M1 - type macrophage polarization [J].Chin J Hepatol, 2018, 26 ( 12) : 916 -921. DOI: 10.3760 / cma. j. issn. 1007 -3418.2018.12.008.
[8] LEE HC, LIAO CC, DAY YJ, et al. IL - 17 deficiency attenuates acetaminophen - induced hepatotoxicity in mice [J].Toxicol Lett, 2018, 292: 20-30.
[9] REX D, AGARWAL N, PRASAD T, et al. A comprehensive pathway map of IL -18 - mediated signalling [J]. J Cell Commun Signal, 2020, 14( 2) : 257 -266. 
[10] QUECK A, BODE H, USCHNER FE, et al. Systemic MCP-1 levels derive mainly from injured liver and are associated with complications in cirrhosis [J]. Front Immunol, 2020, 11: 354. doi: 10. 3389 /fimmu.2020.00354.
[11] AMPOFO E, BERG JJ, MENGER MD, et al. Maslinic acid alleviates ischemia /reperfusion-induced inflammation by downregulation of NFκB-mediated adhesion molecule expression [J].Sci Rep, 2019, 9( 1) : 6119.
[12] LI Z, LIU T, FENG Y, et al. PPARγ alleviates sepsis-induced liver injury by inhibiting hepatocyte pyroptosis via inhibition of the ROS/TXNIP/NLRP3 signaling pathway[J].Oxid Med Cell Longev, 2022, 2022: 1269747. 
[13] KANY S, VOLLRATH JT, RELJA B. Cytokines in inflammatory disease [J].Int J Mol Sci, 2019, 20 ( 23) : 6008.
[14] D'HAESE J, WERNER J. Translational research for acute pancreatitis - which results have really influenced our therapy? [J].Vis Med, 2018, 34 (6): 436-438.
[15] Li S, Zhang Y, Li M, Xie C, Wu H. Serum albumin, a good indicator of persistent organ failure in acute pancreatitis. BMC Gastroenterol 2017; 17: 59.
[16] Shi L, Zhang D, Zhang J. Albumin-bilirubin score is associated with in-hospital mortality in critically ill patients with acute pancreatitis. Eur J Gastroenterol Hepatol 2020; 32: 963-970. 
[17] McCord KW, Webb CB. Hepatic dysfunction. Vet Clin North Am Small Anim Pract 2011; 41: 745- 758.
[18] Liu C, Zhou X, Ling L, Chen S, Zhou J. Prediction of mortality and organ failure based on coagulation and fibrinolysis markers in patients with acute pancreatitis: a retrospective study. Medicine (Baltimore) 2019; 98: e15648 .
[19] LI X J, CAO Y P, LIU Z Y, et al. The relationship between liver injury and serum levels of C-reactive protein and procalcitonin in patients with acute pancreatitis [J]. J Coll Physicians Surg Pak, 2019, 29(3):287-289.  
[20] Pandharipande PV, Krinsky GA, Rusinek H, Lee VS. Perfusion imaging of the liver: current challenges and future goals. Radiology. 2005; 234(3):661-673.
[21] Pieńkowska J, Gwoździewicz K, Skrobisz K,Czarnowska-CubałaM,KozakO,HaćS,Studniarek M, Szurowska E. Can Disturbed Liver Perfusion Revealed in p-CT on the First Day of Acute Pancreatitis Provide Information about the Expected Severity of the Disease? Gastroenterol Res Pract 2019; 2019: 6590729.
[22] Wu D, Zhang M, Xu S, Wu K, Wang N, Wang Y, Wu J, Lu G, Gong W, Ding Y, Xiao W. Nonalcoholic Fatty Liver Disease Aggravated the Severity of Acute Pancreatitis in Patients. Biomed Res Int 2019; 2019: 9583790.
[23] Xiao B, Zhang XM, Jiang ZQ, Tang W, Huang XH, Yang L, Feng ZS. Fatty liver in acute pancreatitis: characteristics in magnetic resonance imaging. J Comput Assist Tomogr 2012; 36: 400-405.
[24] Kong L, Zhang H, Lu C, Shi K, Huang H, Zheng Y, Wang Y, Wang D, Wang H, Huang W. AICAR, an AMP-Activated Protein Kinase Activator, Ameliorates Acute Pancreatitis-Associated Liver Injury Partially Through Nrf2-Mediated Antioxidant Effects and Inhibition of NLRP3 Inflammasome Activation. Front Pharmacol. 2021 Aug 31;12:724514.
[25] Shi Q, Chen C, Deng WH, et al. Hydrogen-Rich Saline Attenuates Acute Hepatic Injury in Acute Necrotizing Pancreatitis by Inhibiting Inflammation and Apoptosis, Involving JNK and p38 Mitogen-Activated Protein Kinase-dependent Reactive Oxygen Species. pancreas. 2016;45(10):1424-1431. 
[26] Qiming Yin, Xiang Song, Peng Yang, et al. Incorporation of glycyrrhizic acid and polyene phosphatidylcholine in lipid nanoparticles ameliorates acute liver injury via delivering p65 siRNA[J]. Nanomedicine: Nanotechnology, Biology and Medicine, 2023, 48: 102649.
[27] J. Zheng, G. Wu, G.X. Hu, Y.Z. Peng, X.J. Xiong, Protective effects against and potential mechanisms underlying the effect of magnesium isoglycyrrhizinate in hypoxia-reoxygenation injury in rat liver cells, Genet. Mol. Res. 14 (2015) 15453-15461.
[28] Fangchao Mei,Jia Yu,Man Li, et al. Magnesium isoglycyrrhizinate alleviates liver injury in obese rats with acute necrotizing pancreatitis[J]. Pathology - Research and Practice, 2019, 215: 106-114.
[29] Y. Wang, Z. Zhang, X. Wang, D. Qi, A. Qu, G. Wang, Amelioration of ethanol-induced hepatitis by magnesium isoglycyrrhizinate through inhibition of neutrophil cell infiltration and oxidative damage, Mediators Inflamm. 2017 (2017) 3526903.
[30] Lv P, Fan LJ, Li HY, Meng QS, Liu J. Protective Effect of Thalidomide on Liver Injury in Rats with Acute Pancreatitis via Inhibition of Oxidative Stress. ann Clin Lab Sci. 2015;45(5):508-514.
[31] Luan ZG, Zhang H, Ma XC, Zhang C, Guo RX. Therapeutic treatment with ethyl pyruvate attenuates the severity of liver injury in rats with severe acute pancreatitis. Pancreas. 2012; 41(5):729-737. 
[32] Silveira, J.P., Seito, L.N., Eberlin, S., Dieamant, G.C., Nogueira, C., Pereda, M.C., Di Stasi, L.C., 2013. Photoprotective and antioxidant effects of Rhubarb: inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1β and α-MSH production in human melanocytes. bmc Complement. altern. med. 13, 1-7.
[33] Li Wu, Huan Li, Shi-zhong Zheng, et al. Da-Huang-Fu-Zi-Tang attenuates liver injury in rats with severe acute pancreatitis [J]. Journal of Ethnopharmacology, 2013, 150: 960-966.
[34] Liu L, Yan H, Liu W, et al. Abdominal Paracentesis Drainage Does Not Increase Infection in Severe Acute Pancreatitis: a Prospective Study. j Clin Gastroenterol. 2015; 49(9):757-763.

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