Advances in the Chemical Components and Pharmacological Effects of Paederia Scandens

Liu Huanyu; Wu Rina; Li Xiaowan; Li Jieqiong; Wang Yixuan; Qiao Lulu; Ma Xin

doi:10.23977/medcm.2024.060207

Advances in the Chemical Components and Pharmacological Effects of Paederia Scandens

Download as PDF

DOI: 10.23977/medcm.2024.060207 | Downloads: 3 | Views: 112

Author(s)

Liu Huanyu ¹, Wu Rina ¹, Li Xiaowan ¹, Li Jieqiong ¹, Wang Yixuan ¹, Qiao Lulu ¹, Ma Xin ¹

Affiliation(s)

¹ Xinjiang Agricultural Vocational Technical College, Changji, 831100, China

Corresponding Author

Wu Rina

ABSTRACT

Paederia scandens (L.) Merr., commonly known as 'ji shi teng' in traditional Chinese medicine, has garnered attention for its medicinal benefits. This review synthesizes the research on its chemical constituents—iridoids, flavonoids, triterpenoids, and essential oils—and their pharmacological effects, including anti-inflammatory, analgesic, gastroprotective, and antioxidant activities. Despite promising pharmacological profiles, the clinical applications of this herb are still limited, highlighting the need for further clinical trials and pharmacokinetic studies. This paper emphasizes the integration of traditional herbal medicine with modern research to fully explore the therapeutic potential of Paederia scandens.

KEYWORDS

Paederia scandens, medicinal plants, pharmacology, anti-inflammatory, analgesic

CITE THIS PAPER

Liu Huanyu, Wu Rina, Li Xiaowan, Li Jieqiong, Wang Yixuan, Qiao Lulu, Ma Xin, Advances in the Chemical Components and Pharmacological Effects of Paederia Scandens. MEDS Chinese Medicine (2024) Vol. 6: 56-63. DOI: http://dx.doi.org/10.23977/medcm.2024.060207.

REFERENCES

[1] Li Q, Guo H, Gong M, et al. Protective Effects of Aqueous Extracts of the Herb of Paederia scandens (Lour.) Merr. against HCl/EtOH-Induced Gastric Ulcer in Rats: Involvement and Inhibitors’ Identification of NF-κB Signaling[J]. Journal of Food Biochemistry, 2023,1-15.
[2] Yang NY, Jiang JL, Liang SY, et al. Study on antibacterial activity in vitro and anti-inflammatory and analgesic effects in vivo of ethanol extract from Paederia foetida[J]. Guangdong Agricultural Sciences, 2022, (008): 049.
[3] Trung NQ, Thanh NTT, Hoa NT, et al. Feruloylmonotropeins: promising natural antioxidants in Paederia scandens[J]. RSC advances, 2023, 13(9): 6153-6159.
[4] Xie Y, Jiang E, Dai T, et al. Simultaneous determination of four Iridoid glycosides from Paederia Scandens in rat plasma by LC-MS/MS and its application to a pharmacokinetic study[J]. Current Analytical Chemistry, 2020, 16(3): 298-307.
[5] He J, Lu X, Wei T, et al. Asperuloside and asperulosidic acid exert an anti-inflammatory effect via suppression of the NF-κB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages[J]. International Journal of Molecular Sciences, 2018, 19(7): 2027.
[6] Tang CL, Ma N, Sun WY, et al. Hepatoprotection of Paederia scandens (Lour.) Merr. on Acetaminophen-Related Hepatic Injury Rats by 1 H-NMR-Based Metabonomics Coupled with Network Pharmacology[J]. Evidence-Based Complementary and Alternative Medicine, 2022,1-14.
[7] Xian J, Lai Q, Chen M. Extraction of total flavonoids from Phyllostachys niger and analysis of their antioxidant properties[J]. Journal of Southern Agriculture, 2013, 44(12): 4.
[8] Tian C, Liu X, Chang Y, et al. Investigation of the anti-inflammatory and antioxidant activities of luteolin, kaempferol, apigenin and quercetin[J]. South African Journal of Botany, 2021, 137: 257-264.
[9] Bridi R, von Poser GL, de Carvalho Meirelles G. Iridoids as a Potential Hepatoprotective Class: A Review[J]. Mini Reviews in Medicinal Chemistry, 2023, 23(4): 452-479.
[10] Chen L, Zeng R, Zhuang Y. In vitro anti-gastric tumor activities and possible mechanisms of action of paederosidic acid from Paederia scandens (Lour) Merrill[J]. Tropical Journal of Pharmaceutical Research, 2015, 14(5): 795-800.
[11] Dai K, Yi XJ, Huang XJ, et al. Hepatoprotective activity of iridoids, seco-iridoids and analog glycosides from Gentianaceae on HepG2 cells via CYP3A4 induction and mitochondrial pathway[J]. Food & function, 2018, 9(5): 2673-2683.
[12] Chen Y, Xu S, Lu Y, et al. Asperuloside suppressing oxidative stress and inflammation in DSS-induced chronic colitis and RAW 264.7 macrophages via Nrf2/HO-1 and NF-κB pathways[J]. Chemico-Biological Interactions, 2021, 344: 109512.
[13] Fan X, Zhou C, Huang C, et al. Asperuloside ameliorates lipopolysaccharide-induced primary human periodontal ligament cell injury by decreasing TLR4 expression and NF-κB activation[J]. Archives of Oral Biology, 2021, 129: 105199.
[14] Rong C, Wei W, Yu-Hong T. Asperuloside exhibits a novel anti-leukemic activity by triggering ER stress-regulated apoptosis via targeting GRP78[J]. Biomedicine & Pharmacotherapy, 2020, 125: 109819.
[15] Li LQ, Song AX, Yin JY, et al. Anti-inflammation activity of exopolysaccharides produced by a medicinal fungus Cordyceps sinensis Cs-HK1 in cell and animal models[J]. International journal of biological macromolecules, 2020, 149: 1042-1050.
[16] Mo M, Li S, Dong Z, et al. S-allylmercaptocysteine ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation and oxidative stress via nuclear factor kappa B and Keap1/Nrf2 pathways[J]. International Immunopharmacology, 2020, 81: 106273.
[17] Zhang C, Li C, Jia X, et al. In vitro and in vivo anti-inflammatory effects of polyphyllin VII through downregulating MAPK and NF-κB pathways[J]. Molecules, 2019, 24(5): 875.
[18] Xu Y, Zeng J, Wang L, et al. Anti-inflammatory iridoid glycosides from Paederia scandens (Lour.) Merrill[J]. Phytochemistry, 2023, 212: 113705.
[19] Liu M, Zhou L, Chen Z, et al. Analgesic effect of iridoid glycosides from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on spared nerve injury rat model of neuropathic pain[J]. Pharmacology Biochemistry and Behavior, 2012, 102(3): 465-470.
[20] Chu C, Huang Y, Chen YF, et al. Anti-nociceptive activity of aqueous fraction from the MeOH extracts of Paederia scandens in mice[J]. Journal of ethnopharmacology, 2008, 118(1): 177-180.
[21] Chen YF, Huang Y, Tang WZ, et al. Antinociceptive activity of Paederosidic Acid Methyl Ester (PAME) from the n-butanol fraction of Paederia scandens in mice[J]. Pharmacology Biochemistry and Behavior, 2009, 93(2): 97-104.
[22] Xiao M, Fu X, Ni Y, et al. Protective effects of Paederia scandens extract on rheumatoid arthritis mouse model by modulating gut microbiota[J]. Journal of ethnopharmacology, 2018, 226: 97-104.
[23] Ai L, Guo L, Liu W, et al. Determination and Mechanism of Antidiarrheal Chemical Constituents of Paederia scandens Determined by HPLC-ESI-MS Integrated with Network Pharmacology[J]. ACS omega, 2023, 8(31): 28834-28845.
[24] Cheng YT, Lu CC, Yen GC. Phytochemicals enhance antioxidant enzyme expression to protect against NSAID‐induced oxidative damage of the gastrointestinal mucosa[J]. Molecular Nutrition & Food Research, 2017, 61(6): 1600659.
[25] Song DS, Kong SX. Clinical experience of Paederia scandens in the treatment of gastrointestinal diseases[J]. Zhejiang Journal of Traditional Chinese Medicine, 2003: 121.
[26] Lei JZ, Huang GH, Tan J, et al. Compatibility Regularity and Network Pharmacology Analysis of Paederia foetida in Treating Spleen and Stomach Diseases[J]. Western Journal of Traditional Chinese Medicine, 2023, 36(4): 52-58.
[27] Peng W, et al. Hepatoprotective activity of total iridoid glycosides isolated from Paederia scandens (lour.) Merr. var. tomentosa[J]. Journal of Ethnopharmacology, 2015, 174: 317-321.

Subscription

E-Mail Alert

Downloads:	4627
Visits:	191443

Advances in the Chemical Components and Pharmacological Effects of Paederia Scandens

Author(s)

Affiliation(s)

Corresponding Author

ABSTRACT

KEYWORDS

CITE THIS PAPER

REFERENCES

RESOURCES

JOIN US

PUBLICATION SERVICES

CONTACT US