Author(s)

Zhangying Wang ¹, Yongbin Gao ¹, He Bin ¹, Yalan Chen ¹, Dongmei Jiang ¹

Affiliation(s)

¹ Department of Respiratory and Critical Care Medicine, The First People's Hospital of Pu'er City, Pu'er, Yunnan, 665000, China

Corresponding Author

Zhangying Wang

ABSTRACT

This investigation evaluates the therapeutic effectiveness of bronchoalveolar lavage (BAL) for severe pneumonia in ethnic minority groups within the Pu'er district. We conducted a prospective, randomized controlled trial involving 68 patients diagnosed with severe pneumonia, assigning 37 to the treatment cohort and 31 to the control cohort. Patients in the treatment cohort underwent BAL, whereas their counterparts received standard care. Outcomes measured were the persistence of clinical symptoms, hospital stay duration, healthcare costs, and hematological markers including leukocyte count, procalcitonin (PCT), and arterial blood gases. Results indicated that the treatment cohort benefitted from a notable reduction in fever, cough, pulmonary rales, and antibiotic administration durations compared to the control (p<0.05). Furthermore, they experienced expedited symptom resolution and incurred lower hospitalization expenses (p<0.05). Arterial blood gas analyses revealed that the treated cohort's post-therapeutic oxygen partial pressures and oxygenation indices were substantially elevated (p<0.05). Although transient supraventricular tachycardia and dips in oxygen saturation were observed, these were not statistically significant (p=0.497). The application of BAL demonstrated pronounced clinical improvements, notably in pulmonary function and in diminishing the duration and cost of hospital care, underscoring its viability and safety with adequate monitoring. The findings offer valuable clinical insights and substantiate BAL's role in managing severe pneumonia in Pu'er and comparable regions.

KEYWORDS

Severe pneumonia, Bronchoalveolar lavage (BAL), Ethnic minorities, Clinical efficacy, Blood gas analysis

CITE THIS PAPER

Zhangying Wang, Yongbin Gao, He Bin, Yalan Chen, Dongmei Jiang, Severe Pneumonia Management and Bronchoalveolar Lavage Efficacy in Yunnan's Ethnic Minorities. MEDS Clinical Medicine (2024) Vol. 5: 54-60. DOI: http://dx.doi.org/10.23977/medsc.2024.050110.

REFERENCES

[1] Hutchison C, Khan M S, Yoong J, et al. Financial barriers and coping strategies: a qualitative study of accessing multidrug-resistant tuberculosis and tuberculosis care in Yunnan, China[J]. BMC public health, 2017, 17(1): 1-11.
[2] Zar H J, Madhi S A, Aston S J, et al. Pneumonia in low and middle income countries: progress and challenges[J]. Thorax, 2013: thoraxjnl-2013-204247.
[3] Hotta T, Kurimoto N, Okimoto T, et al. New procedure of bronchoalveolar lavage using a balloon catheter in diffuse lung diseases [J]. Respiratory investigation, 2020, 58(1): 68-73.
[4] Liu J, Zhao H R, Wei H L, et al. Efficacy of bronchoalveolar lavage as adjunct therapy in the treatment of neonatal severe pneumonia: a prospective case–control study[J]. Journal of Tropical Pediatrics, 2020, 66(5): 528-533.
[5] DeMarco B, MacRosty C R. Bronchoscopic Management of COPD and Advances in Therapy[J]. Life, 2023, 13(4): 1036.
[6] Wang C, Ye S, Wang X, et al. Clinical efficacy and safety of mechanical ventilation combined with fiberoptic bronchoalveolar lavage in patients with severe pulmonary infection[J]. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 2019, 25: 5401.
[7] Meng F, Cheng J, Sang P, et al. Effects of bronchoalveolar lavage with ambroxol hydrochloride on treating pulmonary infection in patients with cerebral infarction and on serum proinflammatory cytokines, MDA and SOD[J]. Computational and Mathematical Methods in Medicine, 2020, 2020.
[8] Tiwari D S, Prakash D V, et el. Comparison of Bronchoalveolar Lavage, Mini Bronchoalveolar Lavage and ET aspirate in diagnosis and management of pneumonia in Intensive Care Unit[J]. Journal of Cardiovascular Disease Research, 2023, 14(09):2309-2314.
[9] Schouten B C, Cox A, Duran G, et al. Mitigating language and cultural barriers in healthcare communication: Toward a holistic approach[J]. Patient Education and Counseling, 2020, 103(12): 2604-2608.
[10] Kamel T, Helms J, Janssen-Langenstein R, et al. Benefit-to-risk balance of bronchoalveolar lavage in the critically ill. A prospective, multicenter cohort study[J]. Intensive care medicine, 2020, 46: 463-474.
[11] Miller A N, Todd A, Toledo R, et al. The relationship of ethnic, racial, and cultural concordance to physician–patient communication: A mixed-methods systematic review protocol[J]. Health Communication, 2023, 38(11): 2370-2376.

Sponsors, Associates, and Links

---

• Journal of Neurobiology and Genetics
  
  
• Medical Imaging and Nuclear Medicine
  
  
• Bacterial Genetics and Ecology
  
  
• Transactions on Cancer
  
  
• Journal of Biophysics and Ecology
  
  
• Journal of Animal Science and Veterinary
  
  
• Academic Journal of Biochemistry and Molecular Biology
  
  
• Transactions on Cell and Developmental Biology
  
  
• Rehabilitation Engineering & Assistive Technology
  
  
• Orthopaedics and Sports Medicine
  
  
• Hematology and Stem Cell
  
  
• Journal of Intelligent Informatics and Biomedical Engineering
  
  
• MEDS Basic Medicine
  
  
• MEDS Stomatology
  
  
• MEDS Public Health and Preventive Medicine
  
  
• MEDS Chinese Medicine
  
  
• Journal of Enzyme Engineering
  
  
• Advances in Industrial Pharmacy and Pharmaceutical Sciences
  
  
• Bacteriology and Microbiology
  
  
• Advances in Physiology and Pathophysiology
  
  
• Journal of Vision and Ophthalmology
  
  
• Frontiers of Obstetrics and Gynecology
  
  
• Digestive Disease and Diabetes
  
  
• Advances in Immunology and Vaccines
  
  
• Nanomedicine and Drug Delivery
  
  
• Cardiology and Vascular System
  
  
• Pediatrics and Child Health
  
  
• Journal of Reproductive Medicine and Contraception
  
  
• Journal of Respiratory and Lung Disease
  
  
• Journal of Bioinformatics and Biomedicine