Precision Medicine Unveiled: Deciphering the Molecular Tapestry of Endotoxin-Induced Acute Lung Injury through microRNA Modulation and Exploring the Therapeutic Nexus with Ligustrazine in the Sun-Luo Microvascular System
DOI: 10.23977/medcm.2024.060102 | Downloads: 4 | Views: 179
Author(s)
Yan Li 1, Huang Xiaojia 1, Liang Junqing 2, Qian Weidong 3
Affiliation(s)
1 Changzhou University, Changzhou, Jiangsu, China
2 Hebei Yiling Medicine Institute, Shijiazhuang, Hebei, China
3 Changzhou Wujin Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China
Corresponding Author
Yan LiABSTRACT
Endotoxin-induced acute lung injury (ALI) poses a severe challenge to critical care medicine, necessitating a profound understanding of its underlying molecular mechanisms for targeted therapeutic interventions. This comprehensive review explores the hypothetical role of microRNA (miRNA) in modulating the Sun-Luo microvascular system's stability, unraveling potential molecular intricacies contributing to ALI pathogenesis. Moreover, it delves into the therapeutic potential of Ligustrazine (Chuanxiongqin), aiming to decipher its impact on the intricate network of miRNA-mediated signaling pathways in mitigating ALI.
KEYWORDS
Acute Lung Injury (ALI); microRNA (miRNA); "Sun-Luo Microvessels" homeostasis; Rho/ROCK pathway; vascular remodelingCITE THIS PAPER
Yan Li, Huang Xiaojia, Liang Junqing, Qian Weidong, Precision Medicine Unveiled: Deciphering the Molecular Tapestry of Endotoxin-Induced Acute Lung Injury through microRNA Modulation and Exploring the Therapeutic Nexus with Ligustrazine in the Sun-Luo Microvascular System. MEDS Chinese Medicine (2024) Vol. 6: 9-16. DOI: http://dx.doi.org/10.23977/medcm.2024.060102.
REFERENCES
[1] Huang M, Cai SL, Su JQ. (2019). The Pathogenesis of Sepsis and Potential Therapeutic Targets. International Journal of Molecular Sciences, 20(21), 5376.
[2] Zhang JH, Tian WY, Wang F, et al. (2023). Advancements in understanding the role of microRnas in regulating macrophage polarization during acute lung injury. Cell Cycle, 22(14-16): 1694-1712.
[3] Chang CC, Wei C, Wu YL. (2016). "Minute Collaterals and Microvessels" Concept and Its Clinical Guiding Significance in Meridian and Collateral Theory. Jounal of Traditional Chinese Medicine, 57(01), 7-11.
[4] Kimura M, Kothari S, Gohir W, et al. (2016). MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets. Clinical Microbiology Reviews, 36(4), e00015-23.
[5] Yuan YH, Yuan R, Xin QQ, et al. (2024). Tetramethylpyrazine and paeoniflorin combination (TMP-PF) inhibits angiogenesis in atherosclerosis via miR-126/VEGF/VEGFR2 signaling pathway. Journal of Future Foods, 4(3), 280-287.
Downloads: | 4221 |
---|---|
Visits: | 167191 |
Sponsors, Associates, and Links
-
MEDS Clinical Medicine
-
Journal of Neurobiology and Genetics
-
Medical Imaging and Nuclear Medicine
-
Bacterial Genetics and Ecology
-
Transactions on Cancer
-
Journal of Biophysics and Ecology
-
Journal of Animal Science and Veterinary
-
Academic Journal of Biochemistry and Molecular Biology
-
Transactions on Cell and Developmental Biology
-
Rehabilitation Engineering & Assistive Technology
-
Orthopaedics and Sports Medicine
-
Hematology and Stem Cell
-
Journal of Intelligent Informatics and Biomedical Engineering
-
MEDS Basic Medicine
-
MEDS Stomatology
-
MEDS Public Health and Preventive Medicine
-
Journal of Enzyme Engineering
-
Advances in Industrial Pharmacy and Pharmaceutical Sciences
-
Bacteriology and Microbiology
-
Advances in Physiology and Pathophysiology
-
Journal of Vision and Ophthalmology
-
Frontiers of Obstetrics and Gynecology
-
Digestive Disease and Diabetes
-
Advances in Immunology and Vaccines
-
Nanomedicine and Drug Delivery
-
Cardiology and Vascular System
-
Pediatrics and Child Health
-
Journal of Reproductive Medicine and Contraception
-
Journal of Respiratory and Lung Disease
-
Journal of Bioinformatics and Biomedicine