Author(s)

Liu Yanhua ¹, Liu Fanrong ²

Affiliation(s)

¹ Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
² Yulin Hospital of Traditional Chinese Medicine, Yulin, Shaanxi, 719051, China

Corresponding Author

Liu Fanrong

ABSTRACT

Hepatocellular carcinoma is an important cause of human death, Icariin has been found to have anti-tumor effects, which have been demonstrated in a variety of oncology experiments. In order to explore the mechanism of Icariin's action on hepatocellular carcinoma, we have analyzed it by using several platforms. Finally, we obtained six targets, which are TNF, PRKCE, PRKCD, IL1B, NFKB1, and PTGS2. Among them, TNF is the key target of Icariin to inhibit hepatocellular carcinoma. Meanwhile, the study also found that Icariin's action on hepatocellular carcinoma may be closely related to immunomodulation, apoptosis, AGE-RAGE, NF-kappaB and other pathways.

KEYWORDS

Liver cancer; Icariin; Network pharmacology

CITE THIS PAPER

Liu Yanhua, Liu Fanrong, Exploration on the Mechanism of the Effect of Icariin on Hepatocellular Carcinoma Based on Network Pharmacology. Transactions on Cancer (2023) Vol. 4: 147-154. DOI: http://dx.doi.org/10.23977/tranc.2023.040121.

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