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Progress of Modern Research on IgA Nephropathy Syndrome of Blood Stasis

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DOI: 10.23977/medcm.2023.051024 | Downloads: 18 | Views: 254

Author(s)

Aishanjiang Aihemaiti 1, Tian Yun 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Shaanxi Provincial Hospital of Chinese Medicine, Xi'an, Shaanxi, 710003, China

Corresponding Author

Tian Yun

ABSTRACT

IgA nephropathy is the most common glomerulonephritis worldwide. Blood stasis syndrome is one of the most common pathogenic factors of IgA nephropathy, and blood stasis is the main factor to accelerate the progression of the disease in the later stage of the disease. Modern medicine provides a scientific and objective basis for blood stasis syndrome in relation to kidney pathology and biochemical indexes. In the theory of traditional Chinese medicine, the formation of blood stasis is both vacuity and substance, and stasis caused by vacuity is often the initiating factor, while evil substance is the secondary factor that aggravates blood stasis. Deficiency syndrome is caused by deficiency of lung, spleen and kidney function during repeated attacks and chronic process of IgA nephropathy. At the same time, water dampness, dampness-heat, dampness-turbidity and other solid evils further aggravate blood stasis syndrome. In this paper, the etiology and pathogenesis of IgAN syndrome of blood stasis in traditional Chinese medicine and the modern objective study of blood stasis syndrome in nephrology are systematically expounded.

KEYWORDS

IgA nephropathy; blood stasis syndrome; promoting blood circulation and removing blood stasis

CITE THIS PAPER

Aishanjiang Aihemaiti, Tian Yun, Progress of Modern Research on IgA Nephropathy Syndrome of Blood Stasis. MEDS Chinese Medicine (2023) Vol. 5: 171-177. DOI: http://dx.doi.org/10.23977/medcm.2023.051024.

REFERENCES

[1] Lai K N, Tang S C W, Schena F P, et al. IgA nephropathy [J]. Nature reviews Disease primers, 2016, 2(1): 1-20. 
[2] Woo K-T, Chan C-M, Mooi C Y, et al. The changing pattern of primary glomerulonephritis in Singapore and other countries over the past 3 decades [J]. Clinical nephrology, 2010, 74(5):372-383. 
[3] Suzuki Hitoshi, Kiryluk Krzysztof, Novak Jan, et al. The pathophysiology of IgA nephropathy [J]. Journal of the American Society of Nephrology : JASN, 2011, 22(10):1795-1803. 
[4] Roberts Ian S D. Pathology of IgA nephropathy [J]. Nature reviews. Nephrology, 2014, 10(8):445-454. 
[5] Appel G B, Waldman M. The IgA nephropathy treatment dilemma [J]. Kidney international, 2006, 69(11):1939-1944.
[6] Chen Xiangmei, Chen Yiping, Li Ping, et al. A Multi-centeric Epidemiological Survey on TCM Syndrome in 1016 Patients with IgA Nephropathy and Analysis of Its Relevant Factors [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2006, (03):197-201. 
[7] Wang Yongjun, Lu Ying. Diagnosis, syndrome differentiation and efficacy evaluation of primary nephrotic syndrome [J]. Shanghai Journal of Traditional Chinese Medicine, 2000, 6 (100): 51-52. 
[8] Wan Tingxin, Zhao Zhuhua, Wang Wenge, et al. Study on the correlation between TCM pathogenic syndromes and Western clinical indicators of primary IgA nephropathy [J]. Chinese Journal of Traditional Chinese Medicine Information, 2014, 21(11):20-23. 
[9] Yu Jiangyi, Xiong Ningning, Yu Chenghui. Chronic kidney disease (CKD) blood stasis and humid pathology, clinical and experimental research [J]. Journal of liao ning TCM complex, 1995 (02): 91-92. 
[10] Li Shen, Wang Suxia, Rao Xiangrong, et al. Correlation Analysis on Blood Stasis Syndrome,Clinical Features and Renal Pathology in 174 Patients with Primary Glomerular Diseases [J]. Chinese Journal of Integrated Traditional and Western Medicine, 2007(06):487-491. 
[11] Huang Meichun, Zheng Shumin, Lu Ying. IgA nephropathy endothelial injury correlation between TCM syndrome type and clinical research [J]. Journal of zhejiang Chinese medicine miscellaneous, 2023, 58 (6): 414-415. 
[12] Li Xiaoming, Shi Saizhu, Niu Huizhi, et al. Determination of plasma endothelin a granular membrane protein 140 in patients with blood stasis syndrome of kidney disease [J]. China Journal of Basic Medicine in Traditional Chinese Medicine, 1996, 2(5):35-36. 
[13] McEver R P. GMP-140: a receptor for neutrophils and monocytes on activated platelets and endothelium [J]. Journal of cellular biochemistry, 1991, 45(2):156-161. 
[14] Barton Matthias, Yanagisawa Masashi. Endothelin: 20 years from discovery to therapy [J]. Canadian journal of physiology and pharmacology, 2008, 86(8):485-498. 
[15] Kohan Donald E, Pollock David M. Endothelin antagonists for diabetic and non-diabetic chronic kidney disease [J]. British journal of clinical pharmacology, 2013, 76(4):573-579. 
[16] Zeng Caihong. Pathological evaluation of IgA nephropathy [J]. Chinese Journal of Medicine, 2019, 100(30):2332-2335. 
[17] YAO Guoming, Chen Hongyu. A Study of Relativity between TCM Syndrome and Clinic Pathology on 1010 Patients with IgA Nephropathy [J].Journal of Medical Research, 2008, 37(8):137-140. 
[18] Cheng Xiaohong, Yu Xiaoyong, Mao Jiarong. Pathological changes and TCM micro-differentiation of IgA nephropathy [J]. Chinese Journal of Integrated Traditional and Western Nephropathy, 2014, 15(02):185-186. 
[19] Wang Liping, Chen Jian, Zhuang Yongze, et al. Correlation analysis of blood stasis syndrome and pathological damage of kidney in IgA nephropathy [J]. Journal of Traditional Chinese Medicine, 2009, 50(07):635-638. 
[20] A. Eldor, M. Orevi, M. Rigbi, et al. The role of the leech in medical therapeutics [J]. Blood Reviews, 1996, 10(4):201-209. 
[21] Lu Ying, Yang Ruchun, Wang Yongjun, et al. Effect of OX-LDL-induced activated macrophages on TGF-β and Fn gene expression and the intervention of hirudin in renal glomerular mesangial cells [J]. Chinese Journal of Integrative Nephropathy, 2007, 8 (11): 631-633. 
[22] Sun Lijiang, Li Yujun, Shi Jingsen. Effect of tetramethylpyrazine on apoptosis of renal cells after ischemia-reperfusion injury [J]. Journal of the Fourth Military Medical University, 2002, (18):1683-1685. 
[23] Wang Xin, Shen Liang, Wang Peizhen. Study on the improvement and application of total glucosides of Paeony on renal fibrinization in rats with diabetic kidney disease through Nrf2/HO-1 pathway [J]. Review of Traditional Chinese Medicine, 2023, 29(04):5-10+16. 
[24] Meng Liqiang, Qu Lei, Li Xiaomei. Effect of Astragalus Angelica Mixture on changes of renal vasoactivity in rats with unilateral ureteral obstruction [J]. Chinese Journal of Nephrology, 2006, 22(2):94-99. 
[25] Lin Qiongzhen, Yu Jie, Deng Yinghui, et al. Protective effect of salvia miltiorrhiza injection on obstructive renal interstitial fibrosis in rats [J]. Chinese Journal of Integrated Traditional and Western Nephropathy, 2003, 4(2):71-73. 
[26] Zhi-Ke Liu, Chun-Fai Ng, Hoi-Ting Shiu, et al. A traditional Chinese formula composed of Chuanxiong Rhizoma and Gastrodiae Rhizoma (Da Chuanxiong Formula) suppresses inflammatory response in LPS -induced RAW 264.7 cells through inhibition of NF-κB pathway [J]. Journal of Ethnopharmacology, 2017, 196:20-28. 
[27] Gesualdo Loreto, Di Leo Vincenzo, Coppo Rosanna, et al. The mucosal immune system and IgA nephropathy [J]. Seminars in immunopathology, 2021, 43(5):657-668. 
[28] Qin Wei, Zhong Xiang, Fan Junming, et al. External suppression causes the low expression of the Cosmc gene in IgA nephropathy [J]. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, 23(5):1608-1614. 
[29] Zhao Hong, Gao Qi, Kong Lingzhou, et al. Semen plantaginis, cyathula compatibility for the treatment of membranous nephropathy network pharmacology study [J]. Chinese herbal medicine new medicine and clinical medicine, 2020, 31 (11): 1343-1349.

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