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  4. Vol 4, Issue 9, 2023

Effect of Gestational Diabetes Mellitus on Pancreatic Development in Offspring

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DOI: 10.23977/medsc.2023.040914 | Downloads: 9 | Views: 269

Author(s)

Yang Huimin 1, Mi Yang 2

Affiliation(s)

1 The Second Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Department of Gynaecology and Obstetrics, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, 710061, China

Corresponding Author

Mi Yang

ABSTRACT

Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, which not only increases the incidence of adverse pregnancy outcomes but also affects the long-term quality of life for both the mother and child. Offspring of GDM display impaired insulin secretion and disrupted glucose metabolism, significantly increasing the risk of developing type 2 diabetes. The pancreas plays a key role in regulating blood glucose homeostasis, and the developmental and functional disturbances of the pancreas in GDM offspring are closely related to the occurrence of metabolic diseases. This review summarizes the changes in morphology, structure, and function of the pancreas in GDM offspring, as well as the underlying mechanisms. The aim is to provide researchers with a better understanding of the pathophysiological mechanisms related to impaired pancreatic development in GDM, and to establish a theoretical basis and new perspectives for the prevention and management of GDM and the health of its offspring. 

KEYWORDS

GDM; Offspring; Pancreas β Cells; Glucose metabolism

CITE THIS PAPER

Yang Huimin, Mi Yang, Effect of Gestational Diabetes Mellitus on Pancreatic Development in Offspring. MEDS Clinical Medicine (2023) Vol. 4: 99-105. DOI: http://dx.doi.org/10.23977/medsc.2023.040914.

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