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  4. Vol 4, Issue 9, 2023

Meta-analysis of the association of ki 67 expression and the clinicopathological features of Triple-negative breast cancer

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DOI: 10.23977/medsc.2023.040903 | Downloads: 17 | Views: 296

Author(s)

Jinfen He 1, Shenwu Wang 1, Xinpei Zhou 2, Zhuang Li 1, Bensi Zhang 2

Affiliation(s)

1 College of Clinical Medicine, Dali University, Dali, Yunnan, China
2 College of Basic Medicine, Dali University, Dali, Yunnan, 671000, China

Corresponding Author

Zhuang Li

ABSTRACT

The objective applied in this paper are to evaluate the correlation of the ki67 tumor-proliferation factors and clinicopathological features in patients by Meta-analysis system, and to provide ideas and methods for the diagnosis and treatment of Triple-negative breast cancer. The results of this analysis can provide a reference for the diagnosis and prognosis of Triple-negative breast cancer, and provide a more effective and reasonable treatment plan for patients. The method is using the Internet retrieval system to retrieve English database Pubmed, the Chinese database CNKI, WanFang database, WEIPU data related database, according to certain search methods and keywords, retrieve all the published about three negative breast cancer ki67 expression and clinical pathological characteristics of the literature, by reading the title and abstract, then gradually read the full text, using Review Manager5.4.1 software for Meta analysis. The results are followings: 13 articles were included in this Meta-analysis, including 616 Triple negative breast cancer patients. The positive expression of ki67 was associated with the histological grade of the tumor, and the menstrual status, the difference was statistically significant; It was not associated with tumor diameter, clinical stage, and lymph node metastasis,the difference was not statistically significant. Meta-analysis results: menstrual status (menopausal): OR: 0.8,95%CI was 0.37-1.75, P=0.58; tumor diameter size: OR: 0.77,95%CI was 0.46-1.29, P=0.32; histological grade: OR: 0.24,95%CI was 0.11-0.52, P=0. 0.0003; clinical stage: OR: 0.72,95%CI was 0.30-1.75, P=0.47; lymph node metastasis: OR: 2.03,95%CI is 0.90-4.61, P = 0. 09. Finaly,the conclusions is as the following:among Triple-negative breast cancer, there is no correlation between positive ki67 expression and menstrual status (menopause), tumor size and clinical stage of Triple-negative breast cancer patients, and there is correlation with histological grade and lymph node metastasis.

KEYWORDS

Triple-negative breast cancer; ki67; Clinicopathological features; Meta-analysis

CITE THIS PAPER

Jinfen He, Shenwu Wang, Xinpei Zhou, Zhuang Li, Bensi Zhang, Meta-analysis of the association of ki 67 expression and the clinicopathological features of Triple-negative breast cancer. MEDS Clinical Medicine (2023) Vol. 4: 15-28. DOI: http://dx.doi.org/10.23977/medsc.2023.040903.

REFERENCES

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