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Research Progress on the Relationship between Heart Failure and Intestinal Microflora in Traditional Chinese and Western Medicine

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DOI: 10.23977/medcm.2023.051016 | Downloads: 3 | Views: 238

Author(s)

Ma Xiaohan 1, Chen Xiao 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, 712046, China
2 Department of Cardiology, Xi'an Fifth Hospital, Xi'an, Shaanxi, 710000, China

Corresponding Author

Ma Xiaohan

ABSTRACT

Heart failure is a group of clinical syndroes caused by dysfunction of ventricular congestion and/or ejection caused by damage to the heart structure or function caused by multiple factors. According to statistics, the number of cardiovascular disease patients in China is about 330 million, of which about 8.9 million are heart failure patients.83% of patients with heart failure were hospitalized at least once a year, and 43% of patients with heart failure were hospitalized at least 4 times a year. Although anti-heart failure drug therapy based on guidelines can improve the hemodynamics of patients, its tolerance, associated adverse effects, and poor prognosis compel continuous exploration of new therapeutic targets and approaches. It has been found that there is a close correlation between intestinal flora and heart failure. Combined with the relevant knowledge of intestinal flora, many experts put forward the theories of "treating psychological spleen", "intestinal mandrel" and "heart-spleen-intestine theory" to explore the relationship between heart failure and intestinal microflora from the theory of traditional Chinese medicine. It provides more ideas for the diagnosis and treatment of heart failure.

KEYWORDS

Heart failure, intestinal flora, correlation, research progress of traditional Chinese and western medicine

CITE THIS PAPER

Ma Xiaohan, Chen Xiao, Research Progress on the Relationship between Heart Failure and Intestinal Microflora in Traditional Chinese and Western Medicine. MEDS Chinese Medicine (2023) Vol. 5: 108-114. DOI: http://dx.doi.org/10.23977/medcm.2023.051016.

REFERENCES

[1] Wang Hua. Review of prevention and control of heart failure in China [J]. Chinese Journal of Cardiovascular, 2019. 24(5): 397-398. 
[2] Heart failure Group of Cardiovascular Society of Chinese Medical Association, Professional Committee of Heart failure of Chinese Medical Association, editorial Board of Chinese Journal of Cardiovascular Diseases. Chinese guidelines for the diagnosis and treatment of Heart failure 2018 [J], Chinese Journal of Cardiovascular Diseases, 2018. , 46(10):760-789. 
[3] Opasich C, Gualco A. The complex symptom burden of the aged heart failure popula-tion [J]. Curr Opin Support Palliat Care, 2007, 1(4):255-259. 
[4] Gavazzi A, De Maria R, Manzoli L, etal. Palliative needs for heart failure or chronic obstructive pulmonary disease: results of amulticenter observational registry[J]. IntJ Cardiol, 2015, 184: 552-558. 
[5] Portas González M, Garutti Martínez I, Fernández-Quero BonillaL. Gastrointestinal tonometry: a new tool for the anesthesiologist [J]. Rev Esp Anestesiol Reanim, 2003, 50 (8):401- 408. 
[6] Krack A, Sharma R, Figulla HR, etal. The importance of the gastrointestinal system in the pathogenesis of heart failure [J]. Eur Heart J, 2005, 26(22): 2368-2374. 
[7] Romeiro FG, Okoshi K, Zornoff LA, etal. Gastrointestinal changes associated to heart failure[J]. Arq Bras Cardiol, 2012, 98(3):273-277. 
[8] Sandek A, Swidsinski A, Schroedl W, etal. Intestinal blood flow in patients with chronic heart failure: a link with bacterial growth, gastrointestinal symptoms, and cachexia[J]. J Am Coll Cardiol, 2014, 64(11):1092-1102. 
[9] Sandek A, Bjarnason I, Volk HD, etal. Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure[J]. Int J Cardiol, 2012, 157(1):80-85. 
[10] ThiererJ, Acosta A, Vainstein N, etal. Relation of left ventricular ejection fraction and functional capacity with metabolism and inflammation in chronic heart failure with reduced ejection fraction (from the MIMICA Study) [J]. Am J Cardiol, 2010, 105(7): 977-983. 
[11] Dicken B, Cleland JG. Is the way to a man's heart through his stomach? Intestinal blood flow, gut permeability, and heart failure[J]. JAm Coll Cardiol, 2014, 64(11): 1103-1105. 
[12] Sandek A, Bjarnason I, Volk HD, etal. Studies on bacterial endotoxin and intestinal absorption function in patients with chronic heart failure[J]. Int J Cardiol, 2012, 157(1):80-85. 
[13] Pasini E, Aquilani R, Testa C, etal. Pathogenic gut flora in patients with chronicheart failure [J]. JACC Heart Fail, 2016, 4(3):220-227. 
[14] Al-Rubaye H, Perfetti G, Kaski JC. The role of microbiota in cardiovascular risk: focus on trimethylamine oxide [J]. Curr Probl Cardiol, 2019, 44(6):182-196. 
[15] Bennett BJ, De AguiarVallim TQ, Wang Z, etal. Trimethylamine-N-oxide, ametabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation [J]. Cell Metab, 2013, 17(1):49-60. 
[16] SANDEK A, BAUDITZ J A, BUHNER S, etal. Altered intestinal functioninpatients with chronic heart failure[J]. Journal of the A-merican College of Cardiology, 2007, 50(16):1561-1569. 
[17] Ding T, Schloss PD. Dynamics and associations of microbial community types across the human body[J]. Nature, 2014, 509. 
[18] Tang W, Wang ZE, Fan YY, etal. Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine- N-oxide in patients with heart failure refining the gut hypothesis[J]. J Am Coll Cardiol, 2014, 64(18): 1908-1914. 
[19] SANDEK A, ANKERSD, VONHS. The gut and intestinal bacteria in chronic heart failure[J]. Current Drug Metabolism, 2009, 10(1):112. 
[20] Luedde M, Winkler T, Heinsen FA, etal. Heart failure is associated with depletion of core intestinal microbiota [J]. ESC Heart Fail, 2017, 4(3):282-290. 
[21] Suzuki T, Yazaki Y, VoorsAA, et al. Association with outcomes and responsetotreatment of trimethylamine N-oxide in heart failure (from BIOSTAT-CHF) [J]Eur JHeart Fail, 2018 Oct 29. 
[22] Hayashi T, Yamashita T, Watanabe H, etal. Gut Microbiome and plasma microbiome-related metabolites in patients with decompensated and compensated heart failure [J]. Circ J, 2018, 83(1):182-192. 
[23] Kitai T, Tang W. Gut microbiota in cardiovascular disease and heart failure[J]. ClinSci (Lond), 2018, 132 (1):85-91. 
[24] Ueland T, Gullestad L, Nymo SH, etal. Inflammatory cytokines asbiomarkers in heart failur[J]. Clin ChimActa, 2015, 443: 71-77. 
[25] FORMIGA F, FERREIRA T C I, CHIVITE D. Impact of intestinal microbiota in patients with heart failure:a systematic review [J]. Med Clin, 2019, 153(10):402-409. 
[26] DONG Z, LIANG Z, WANG X, etal. The correlation between plasma trimethylamine N-oxide level and heart failure classification in northern Chinese patients [J]. Ann Palliat Med, 2020, 9(5):2862-2871. 
[27] YOSHIDA Y, SHIMIZU I, SHIMADA A, etal. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism [J]. Sci Rep, 2022, 12(1):14883. 
[28] FüLöP P, DVOROŽŇáKOVá M, VACHALCOVá M, et al. Gut microbiome in heart failure and aortic stenosis[J]. Vnitr Lek, 2022, 68(E-2):4-10. 
[29] LV S, WANG Y, ZHANG W, etal. Trimethylamine oxide:a potential target for heart failure therapy[J]. Heart, 2022, 108(12):917-922. 
[30] COUTINHO-WOLINO K S, DE F C L F M, DE OLIVEIRA LEAL V, etal. Can diet modulate trimethylamine N-oxide (TMAO) production [J]. Eur J Nutr, 2021, 60(7):3567-3584. 
[31] Wu Wei, Liu Yong, Zhao Yingqiang. Heart failure as a TCM disease name of heart failure [J]. Journal of traditional Chinese Medicine, 2013 (10): 86-87. 
[32] Zhao Wenjing, Miao Yang, Ma Xiaochang. Syndrome differentiation and treatment of chronic congestive heart failure [J]. Journal of Cardiovascular and Cerebrovascular Diseases of Integrated traditional Chinese and Western Medicine, 2008, (07): 816, 817.  
[33] Tong Cuncun, Zhao Mingjun, Zhou Duan, etc. Experience of contemporary famous TCM experts in differential diagnosis and treatment of chronic heart failure [J]. Shaanxi traditional Chinese Medicine, 2011, 32 (09): 1269-1271.

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