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Study on the Related Mechanism of Insomnia

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DOI: 10.23977/phpm.2023.030610 | Downloads: 27 | Views: 683

Author(s)

Fangyuan Chen 1, Hai Lin 1

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China

Corresponding Author

Hai Lin

ABSTRACT

As a physiological activity, good sleep is of great significance to people's life and work. In recent years, with the advancement of science and technology and the acceleration of the pace of life, people's schedules have changed, and staying up late and going to bed late have become more and more common in big cities. Work stress, along with life stress, increases the incidence of insomnia. This rapidly rising incidence of insomnia has gradually become a social problem from affecting the life and work of individuals. Insomnia has begun to attract people's attention, and more and more scientists and doctors have begun to study the onset and treatment of insomnia. Many studies have explored the mechanisms involved in insomnia in many ways. In this review, we will explore the mechanism of insomnia and its mechanism-related signaling pathways from five aspects: immune function, oxidative stress state, inflammatory response, apoptosis, and brain-gut axis system. Through the collation of research data, it was found that the mRNA expression level of TLR-related genes decreased, which could improve insomnia in rats. Reducing the levels of SOD and nos in rats can prolong the duration of insomnia; increasing the content of cAMP in rat hypothalamus can improve sleep in rats; increasing the expression of Bcl-2 protein and decreasing Bax protein in rats can improve sleep. Reducing Fas/FasL protein in rats can improve sleep quality; the gut microbiota can affect sleep in rats.

KEYWORDS

Insomnia, Mechanism, Immune Function, Oxidative Stress, Inverse Reaction, Cell Apoptosis, Cerebrointestinal Axis, Signal Path

CITE THIS PAPER

Fangyuan Chen, Hai Lin, Study on the Related Mechanism of Insomnia. MEDS Public Health and Preventive Medicine (2023) Vol. 3: 65-71. DOI: http://dx.doi.org/10.23977/phpm.2023.030610.

REFERENCES

[1] Chinese sleep Research Society. Guidelines for diagnosis and treatment of insomnia in China. Chinese Medical Journal, 2017, 97(24):1844-1856.
[2] Du Jinlei, Zhang Tianyuan, Yang Yingying. Research progress of Traditional Chinese and Western medicine in treating insomnia. Modern Distance education of Traditional Chinese Medicine in China, 2022, 20(17):203-206.
[3] Rechtschaffen A, Bergmann BM. Sleep deprivation and host defense. Am J Physiol Regul Integr Comp Physiol, 2001, 280(2):602-603.
[4] Krueger J M, Walter J, Dinarello C A, et al. Sleep-promoting effects of endogenous pyrogen(IL-1). Am J Physiol, 1984, 246(6):994-998.
[5] Spath-Schualbe E. Hansen K. Schmidt F, et al. Acute effect of recombinant human interleukin -6 on endocrine and centralnervors sleep function in healthy men. J Clin Endocrinol Metab, 1998, 83(5):1573-1579.
[6] Shoham S. Devenhe D. Cady AB et al. Recombmant tumor necrosis factor and IL~1 enhance slow-wave sleep. Am J Physiol, 1987, 25(3):R142-149.
[7] Yang Hongpeng, Zhang Shouguo, Cao Ying et al. Research progress of Toll-like receptor related diseases. Science Technology and Engineering, 2022, 22(35):15427-15435.
[8] Qiao Tie, Liang Ke, Li Fangxiao et al. Study on the mechanism of regulating TLR/NF-κB signaling pathway of Schisandra chinensis to improve sleep. Journal of Practical Chinese Medicine Internal Medicine, 2023, 37(08):121-123+190. DOI:10.13729/j.issn.1671-7813.Z20230839.
[9] Wang Qiulin, Wang Haoyi, Wang Shuren. Evaluation of oxidative stress status. Chinese Journal of Pathophysiology, 2005(10):2069-2074.
[10] Zhou Y, Little P J, Downey L, et al. The role of Toll-like receptors in atherothrombotic cardiovascular disease. ACS Pharmacology & Translational Science, 2020, 3(3):457-471.
[11] Wang Xinyuan, Pan Yan, Li Ling et al. Study on serum oxidative stress factor in patients with non-organic insomnia. Chinese Journal of Neuropsychiatric Disorders, 2018, 44(12):744-747.
[12] Li Li, Liu Ru, He Jing et al. Effects of Wendan Decoction on oxidative stress and inflammation in sleep deprived mice. Chinese Journal of Immunology, 2022, 38(03):308-312.
[13] Zhao Canghuan, Lin Zimin, Jiang Li. Effect of moxibustion on NO and NOS in hypothalamus of insomnia rats // Chinese Society of Acupuncture and Moxibustion. Proceedings of 2011 Annual Meeting of Chinese Acupuncture Society (Abstract). [Publisher unknown], 2011:6.
[14] Hu Baolig, Gao Yufeng. Effect of moxibustion on NO and NOS in brain of insomnia model rats. Electronic Journal of Clinical Medical Literature, 2016, 3(08):1403-1404. DOI:10.16281/j.cnki.jocml.2016.08.010.
[15] Liu Yin, Tang Yonghong, Zhai Jinxia et al. Research progress of chronic low-grade inflammation and sleep disorders. Chinese Journal of Modern Neurological Diseases, 2023, 23(08):674-677.
[16] Schuh R A, Kristián T, Fiskum G. Calcium-dependent dephosphorylation of brain mitochondrial calcium/cAMP response element binding protein ( CREB). Journal of Neurochemistry, 2010, 92(2):388-394.
[17] Yan Wei, Chen Ling, Wang Fei, et al. Effects of phosphodiesterase 2 on central nervous system diseases such as depression, anxiety and cognitive impairment. Chinese Clinical Pharmacology and Therapeutics, 2013, 18(12):1424-1429.
[18] Korhonen R, Hömmö T, Keränen T, Laavola M, Hämäläinen M, Vuolteenaho K, Lehtimäki L, Kankaanranta H, Moilanen E. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol, 2013 Aug, 169(7):25-36.
[19] Zeng Xueai, Zhou Chunquan, Wu Huasong et al. Effect of Songyu Anshen prescription on sleep improvement in insomnia rats through cAMP/CREB signaling pathway. New Chinese medicine and clinical pharmacology, 2022, 33(10):1322-1327. DOI:10.19378/j.issn.1003-9783.2022.10.005.
[20] Guo Jinliang, Yang Qian, Wang Ruoyu et al. Effects of hypnotic active components of Fructus cnidii on pineal cell apoptosis and related Bcl-2/Bax protein expression in PCPA insomnia rats. Journal of Traditional Chinese Medicine, 2022, 50(01):23-27. DOI:10.19664/j.cnki.1002-2392.220006.
[21] Li D. Effects of glycyrrhizic acid on oxidative stress and apoptosis of H9c2 cells induced by hydrogen peroxide. Xinxiang Medical College, 2020. DOI:10.27434/d.cnki.gxxyc.2020.000235.
[22] He Song. Effect of Tianwang Buxin Prescription on IL-21 mediated inflammation and Fas/FasL mediated neuronal apoptosis in hippocampus of PCPA insomnia rats. Hubei University of Chinese Medicine, 2020. DOI:10.27134/d.cnki.ghbzc.2020.000307.
[23] Vakil N, Wernersson B, Wissmar J, Dent J. Sleep disturbance due to heartburn and regurgitation is common in patients with functional dyspepsia. United European Gastroenterol J, 2016 Apr, 4(2):191-198. DOI:10.1177/ 2050640615599716. Epub 2015 Aug 6. PMID: 27087946; PMCID: PMC4804370.
[24] Ju Kun, Shi Qingchun, Guan Ruiqian et al. Study on mechanism of Jiaotai pills in treating primary insomnia based on intestinal flora. Journal of Psychiatry, 2022, 35(05):543-547.

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