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  4. Vol 5, Issue 10, 2023

Mechanism of Banxia-Huanglian in the Treatment of Diabetes from the Perspective of Network Pharmacology Based on "Xin Kai Ku Jiang" Theory

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DOI: 10.23977/medcm.2023.051001 | Downloads: 10 | Views: 269

Author(s)

Wu Yun 1, Qu Kai 2, Qi Haiyan 1, Ding Yanlin 1, Xie Lei 1, Xu Jianqin 2

Affiliation(s)

1 Shaanxi University of Traditional Chinese Medicine, Xianyang, China
2 Shaanxi Province Hospital of Traditional Chinese Medicine, Xi'an, China

Corresponding Author

Xu Jianqin

ABSTRACT

Our purpose is to explore the mechanism of Banxia-Huanglian in the treatment of diabetes from the perspective of network pharmacology based on the theory of " Xin Kai Ku Jiang".Our method was to use Traditional Chinese Medicine Systems Pharmacology database (TCMSP) and Swiss Target Prediction database to search the chemically active components and their respective targets of Banxia and Huanglian,and to use GeneCards database, DisGeNET database, OMIM database and Drugbank database to collect the diabetes-related targets. The intersection targets of the Banxia-Huanglian and diabetes were input into the online database of STRING, thus the protein-protein interaction (PPI) network was obtained. Then GO and KEGG enrichment analysis was carried out by Metascape and the " Banxia-Huanglian active components - targets-pathways" network diagram was constructed by Cytoscape3.6.1 software.Finally,Autodock Tolls software was used for molecular docking.The results of this study were as follows: A total of 22 active components,175 potential targets,1812 targets of Diabetes,and 99 targets of intersection targets was obtained.The network analysis results showed that the key chemical components of Banxia-Huanglian in the treatment of diabetes mainly involve quercetin, baicalein and beta-sitosterol,and the key targets included MAPK1,AKT1 and PTGS2. We concluded that Banxia-Huanglian has an inhibiting inflammatory response, regulating glycolipid metabolism and reducing insulin resistance effect mainly by hypoglycemic, thereby playing a role in the treatment of diabetes. 

KEYWORDS

Diabetes; Banxia-Huanglian; Xin Kai Ku Jiang; network pharmacology; Molecular docking

CITE THIS PAPER

Wu Yun, Qu Kai, Qi Haiyan, Ding Yanlin, Xie Lei, Xu Jianqin, Mechanism of Banxia-Huanglian in the Treatment of Diabetes from the Perspective of Network Pharmacology Based on "Xin Kai Ku Jiang" Theory. MEDS Chinese Medicine (2023) Vol. 5: 1-8. DOI: http://dx.doi.org/10.23977/medcm.2023.051001.

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