Synthesis of (E)-N, N-dimethyl-N'-(4-(4-nitrophenoxy) picolinoyl) formohydrazonamide
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DOI: 10.23977/misbp.2021045
Author(s)
Wenhui Gan, Jinjin Wu, Hualan Zhou, Min Liao, Shan Xu, Pengwu Zheng
Corresponding Author
Pengwu Zheng
ABSTRACT
(E)-N, N-dimethyl-N'-(4-(4-nitrophenoxy) picolinoyl) formohydrazonamide (8) is considered as an important intermediate of many antitumor drugs. Compound 8 was synthesized from 6-chloropyrimidine-4-amine by three steps nucleophilic substitution. The structures of the intermediates were confirmed by MS. Furthermore, the synthetic method was optimized.
KEYWORDS
N (E)-N, N-dimethyl-N'- (4-(4-nitrophenoxy) picolinoyl) formohydrazonamide, Antitumor drugs, Synthesis