Synthesis of aniline analogs containing different secondary amines
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DOI: 10.23977/misbp.2021044
Author(s)
Feiyi Yang, Xiaohan Hu, Zihan Zhan, Wufu Zhu, Shan Xu
Corresponding Author
Shan Xu
ABSTRACT
Aniline analogs containing different secondary amines are important intermediates of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds was established. Compounds 2a-c were synthesized from p-nitrochlorobenzene through two steps including reduction reaction and nucleophilic substitution. The structure of the target compounds was confirmed by 1H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the two steps was up to 56%.
KEYWORDS
Aniline analogs, Secondary amines, Synthesis