The Development and Mechanism of the CAR-T Therapy
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DOI: 10.23977/misbp.2021012
Author(s)
Sijia Chen, Yujie Lu, Xiang Yin
Corresponding Author
Sijia Chen
ABSTRACT
The immunotherapy of cancer has been a popular topic and has been developing very fast in recent years. Chimeric antigen receptor T cell therapy, as known as CAR T cell therapy is an adoptive cell therapy that modifies the T cells from the patient with specific receptors which can recognise the antigen on the surface of tumour cells, reinject the T cells back in order to kill the tumour cells efficiently. This fantastic way of modifying the patient's T cells to fight cancer has shown its value in treating B-cell malignancies and Multiple myeloma with remarkable efficiency. Further generation of CAR-T cell therapy should aim for reduced patient expenditure and side effects to encounter associated challenges. This review introduced the mechanism of the CAR-T cell therapy, the targeted cancers, challenges, and the future of the therapy.
KEYWORDS
Adoptive cell therapy, Malignancies, tumour immunotherapy