Author(s)

Siya Peng

Corresponding Author

Siya Peng

ABSTRACT

Depression is one of the most common mental health problems in adolescents, which can lead to serious negative influence on school maladaptation, social adaptation, healthy development, even increase the risk of self-injury and suicide. Increasing number of studies demonstrate that both brain changes and environmental factors are relevant to depressive symptoms and disorder in adolescents. The present study is interested in the brain changes related to adolescent depression and how the environmental factors interact with the brain under the depression. Specifically, this study reviewed the influence of the alter in brain structure (e.g., white matter abnormality) and large-scale brain functional networks (e.g., default mode network) of adolescent depression. Moreover, the present review also introduced some environmental factors (e.g., parenting style) and how they can predict adolescent depression by affecting related brain structure and function. Finally, the limitations of the present study and suggestions for future studies are also conducted.

KEYWORDS

Depression, adolescent, brain structure, functional connectivity, environmental factors