Pharmacological Effects of Polygala Tenuifolia and Research Progress on Its Prevention and Treatment of Alzheimer's Disease

Wang Qiutong; Zhang Qiming

doi:10.23977/medbm.2023.010209

Pharmacological Effects of Polygala Tenuifolia and Research Progress on Its Prevention and Treatment of Alzheimer's Disease

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DOI: 10.23977/medbm.2023.010209 | Downloads: 4 | Views: 315

Author(s)

Wang Qiutong ¹, Zhang Qiming ²

Affiliation(s)

¹ The First Clinical College of Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
² Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China

Corresponding Author

Zhang Qiming

ABSTRACT

As a traditional Chinese medicine, Polygala tenuifolia has a long history of medicinal use, well-established efficacy, and a wide range of applications, all of which have been documented in various herbal classics throughout the dynasties. It is known for its ability to nourish the liver and kidneys, strengthen tendons and bones, and enhance cognitive function while calming the nerves. Modern pharmacological research has shown that Polygala tenuifolia contains various components that can inhibit the formation of beta-amyloid proteins in the brain. It exerts its effects through multiple pathways and targets, thereby inhibiting the degenerative development of brain neurons. This makes it an effective preventive and therapeutic agent for Alzheimer's disease. Additionally, it possesses sedative, anti-inflammatory, antioxidant, cough-suppressing, and phlegm-reducing properties, along with anti-mutagenic effects. This article provides an overview of the pharmacological effects of Polygala tenuifolia and the research progress on its prevention and treatment of Alzheimer's disease. It highlights the potential for comprehensive clinical utilization of Polygala tenuifolia and offers prospects for its further exploration in the prevention and treatment of Alzheimer's disease.

KEYWORDS

Polygala tenuifolia; Pharmacological Effects; Alzheimer's Disease; Research Progress

CITE THIS PAPER

Wang Qiutong, Zhang Qiming, Pharmacological Effects of Polygala Tenuifolia and Research Progress on Its Prevention and Treatment of Alzheimer's Disease. MEDS Basic Medicine (2023) Vol. 1: 52-59. DOI: http://dx.doi.org/10.23977/medbm.2023.010209.

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Pharmacological Effects of Polygala Tenuifolia and Research Progress on Its Prevention and Treatment of Alzheimer's Disease

Author(s)

Affiliation(s)

Corresponding Author

ABSTRACT

KEYWORDS

CITE THIS PAPER

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