Author(s)

Shasha Zang ¹, Sha Liu ²

Affiliation(s)

¹ Department of Geriatrics, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, China
² Department of Cardiology, Affiliated Hospital of Hebei University, Baoding, Hebei, 071000, China

Corresponding Author

Sha Liu

ABSTRACT

The objective of this study was to analyze the correlation between insulin resistance (IR) in diabetes mellitus (DM) and cardiovascular endocrine hormone (CEH) in the elderly population. In our research methodology, we selected 58 elderly DM patients from the endocrinology department of our hospital as the observation group (OG) and compared them to 58 healthy individuals, who served as the control group (CG). By retrospectively analyzing the IR index of all 116 participants, we measured indicators such as insulin and C peptide (CP) using radioimmunoassay. Furthermore, we conducted a glucose tolerance test (OG-TT). Cardiovascular endocrine hormones like atrial natriuretic peptide (ANP), endothelin (ET), angiotensin I, II (AI, AII), insulin, and CP were determined through radioimmunoassay, while catechol aminophenol (CA), epinephrine (E), and norepinephrine (NE) were ascertained using fluorescence analysis. Our results indicated that the levels of ANP, ET, AⅡ, CA, EN, and E in OG patients were significantly higher than those in the CG group (P < 0.05). During the insulin release experiment for DMIR patients, the insulin levels recorded at intervals of 0h, 2h, and 4h differed notably from those of the healthy individuals (P < 0.05). However, there was no significant variation in CP levels between DMIR patients and the healthy group (P > 0.05). A multiple linear regression analysis highlighted that ANP, ET, AII, CA, 2h glucose tolerance, and insulin release at 1h post meal consumption are the primary factors influencing the IR index. In conclusion, the study reveals that IR in elderly DM patients has a relationship with CEH disorders. Monitoring CEH levels can therefore be instrumental in offering evidence-based treatments.

KEYWORDS

Diabetes mellitus; cardiovascular endocrine hormones; insulin resistance

CITE THIS PAPER

Shasha Zang, Sha Liu, Correlation between diabetes mellitus insulin resistance and cardiovascular endocrine hormones in the elderly. Social Medicine and Health Management (2023) Vol. 4: 11-15. DOI: http://dx.doi.org/10.23977/socmhm.2023.040402.

REFERENCES

[1] Mihai, V. C., Loredana, P., Lucia, D., Mdlina, M., Mircea, P., & Gabriela, R., et al. (2018). Insulin resistance (ir) in patients with type 2 diabetes mellitus. Identifying predictors of insulin resistance and establishing a correlation between insulin resistance and cardiovascular risk. Internal Medicine, 15(2), 7-15.
[2] Rogowicz-Frontczak, A., Majchrzak, A., & Zozulińska-Ziółkiewicz D. (2017). Insulin resistance in endocrine disorders - treatment options. Endokrynologia Polska, 68(3), 334.
[3] Lambadiari, V., Mitrou, P., Maratou, E., Raptis, A. E., Tountas, N., & Raptis, S. A., et al. (2011). Thyroid hormones are positively associated with insulin resistance early in the development of type 2 diabetes. Endocrine, 39(1), 28-32.
[4] Cohen, D. H., & Leroith, D. (2012). Obesity, type 2 diabetes, and cancer: the insulin and igf connection. Endocrine-related cancer (5), 19.
[5] Ferrie, J. J., Gruskos, J. J., Goldwaser, A. L., Decker, M. E., & Guarracino, D. A. (2013). A comparative protease stability study of synthetic macrocyclic peptides that mimic two endocrine hormones. Bioorganic & medicinal chemistry letters, 23(4), 989-995.
[6] HuangYing, & Fu, Z. D. (2011). Effect of benazepril and metoroolol on neuroendocrine hormones in congestive heart failure. Heart, 97(Suppl 3), A217.
[7] Giannoulis, M. G., Martin, F. C., Sreekumaran, N. K., Margot, U. A., & Peter, S. (2012). Hormone replacement therapy and physical function in healthy older men. Time to talk hormones? Endocrine reviews, 33(3), 314-377.
[8] Gulati, A. P., Krantz, B., Moss, R. A., Moyal, W. N., Tsushima, D. A., & Mowatt, K. B., et al. (2012). Treatment of multiple endocrine neoplasia 1/2 tumors: case report and review of the literature. Oncology, 84(3), 127-134.
[9] Ha, C. H., Swearingin, B., & Jeon, Y. K. (2015). Relationship of visfatin level to pancreatic endocrine hormone level, homa-ir index, and homa β-cell index in overweight women who performed hydraulic resistance exercise. Journal of Physical Therapy Science, 27(9), 2965-2969.
[10] Jin-wei Xia, Shi-jin Tan, et al. (2015). Correlation of serum testosterone with insulin resistance in elderly male type2 diabetes mellitus patients with osteoporosis. Journal of Diabetes Investigation, 6(5), 548-552.
[11] Wolf, G. (2010). Insulin resistance associated with leptin deficiency in mice: a possible model for noninsulin-dependent diabetes mellitus. Nutrition Reviews (6), 177-179.
[12] Ohkura, T., Fujioka, Y., Nakanishi, R., Shiochi, H., Sumi, K., & Yamamoto, N., et al. (2014). Low serum galectin-3 concentrations are associated with insulin resistance in patients with type 2 diabetes mellitus. Diabetology & Metabolic Syndrome, 6(1), 1-7.
[13] Ruskovska, T., & Bernlohr, D. A. (2013). Oxidative stress and protein carbonylation in adipose tissue— implications for insulin resistance and diabetes mellitus. Journal of Proteomics, 92(10), 323-334.
[14] Tripathy, D., & Chavez, A. O. (2010). Defects in insulin secretion and action in the pathogenesis of type 2 diabetes mellitus. Current Diabetes Reports, 10(3), 184-191.

Sponsors, Associates, and Links

---

• Information Systems and Economics
  
  
• Accounting, Auditing and Finance
  
  
• Industrial Engineering and Innovation Management
  
  
• Tourism Management and Technology Economy
  
  
• Journal of Computational and Financial Econometrics
  
  
• Financial Engineering and Risk Management
  
  
• Accounting and Corporate Management
  
  
• Social Security and Administration Management
  
  
• Population, Resources & Environmental Economics
  
  
• Statistics & Quantitative Economics
  
  
• Agricultural & Forestry Economics and Management
  
  
• Land Resource Management
  
  
• Information, Library and Archival Science
  
  
• Journal of Human Resource Development
  
  
• Manufacturing and Service Operations Management
  
  
• Operational Research and Cybernetics