Author(s)

Hui Wang ¹, Fangfang Dong ¹, Chan Zhao ²

Affiliation(s)

¹ First Clinical School of Medicine, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
² Department of Dermatology, Baoji Hospital of Traditional Chinese Medicine, Baoji, Shaanxi, 721000, China

Corresponding Author

Chan Zhao

ABSTRACT

A 73-year-old female patient with small artery occlusive cerebral infarction was given atorvastatin calcium tablets 20 mg orally once/d, aspirin enteric-coated tablets 100 mg orally once/d, Clopidogrel bisulfate tablets 75 mg orally once/d, Citicoline sodium tablets 200 mg orally three times/d, and butylphthalide and sodium chloride injection 100 ml intravenously twice/d.nine days later, the body appeared scattered erythema with sharply demarcated and different sizes, which was considered to be caused by butyl phthalein sodium chloride injection or Clopidogrel bisulfate tablets. This drug was discontinued and other drugs continued to be used. Three days later, the body temperature began to rise, reaching over 38 ℃. On the fourth day, the body temperature continued to rise, presenting classical skin lesions: Based on generalized diffuse, edematous erythema, there were dense, superficial, non-follicular yellow-white pustules, some of which formed pus lakes. After a consultation with a dermatologist, the patient was diagnosed with acute generalized exanthematous pustulosis, and treated with intravenous drips of methylprednisolone, human immunoglobin and human albumin, etc. After 3 weeks of symptomatic treatment, the skin lesions were cured. Clopidogrel bisulfate tablets were re-applied after specialist evaluation and no similar lesions occurred.

KEYWORDS

Brain infarction, Acute generalized exanthematous pustulosis, Butylphthalide and sodium chloride injection, Clopidogrel bisulfate tablets

CITE THIS PAPER

Hui Wang, Fangfang Dong, Chan Zhao, A case of acute generalized exanthematous pustulosis caused by butylphthalide sodium chloride injection and review of the literature. MEDS Basic Medicine (2023) Vol. 1: 34-37. DOI: http://dx.doi.org/10.23977/medbm.2023.010107.

REFERENCES

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