Author(s)

Jiayue Sun ¹

Affiliation(s)

¹ University of British Columbia, Vancouver, Canada

Corresponding Author

ABSTRACT

Microglia play an important role in the course of ICH (Intracerebral Hemorr-Hage), and its activation degree, phenotypic polarization, hematoma clearance mechanism and its interaction with nerve cells are hot topics in ICH research at present. In this paper, ICH was taken as an example, and the research progress of microglia function changes after ICH was summarized, and the phenotypic transformation of microglia was summarized. The nitrite peroxide produced by M1 microglia in the immune reaction externalizes the phosphoacyl serine residues outside the nerve cells and sends out phagocytic signals, so that microglia can play the role of brain phagocytosis and cause nerve cell damage. The expression of pro-inflammatory microglia (M1 type) and repair microglia (M2 type) increased, and the microglia were mainly M1 type. In addition, the expression of M1 microglia in ICH 72 h group was lower than that in ICH 24 h group, while the expression of M2 microglia in ICH72 h group was higher than that in ICH 24 h group. Compared with Sham group, the increasing trend of M1 microglia expression after ICH is consistent with the increasing trend of TLR4/NF-κ B.

KEYWORDS

CITE THIS PAPER

Jiayue Sun, Physiological Study of Microglial Cell Polarization. MEDS Basic Medicine (2023) Vol. 1: 23-28. DOI: http://dx.doi.org/10.23977/medbm.2023.010105.

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