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Intervention of Bacterial Lysate in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

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DOI: 10.23977/bactm.2022.020101 | Downloads: 26 | Views: 1519


Yafei Qi 1, Weimin Zhang 1, Yinhuan Li 1


1 Pulmonary and Critical Care Medicine, Panyu Central Hospital, Guangzhou 511400, Guangdong, China

Corresponding Author

Yafei Qi


To study the performance of bacterial lysates in the treatment of acute exacerbation of chronic obstructive pulmonary disease(COPD). 60 patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) admitted in our hospital from November 2020 to June 2021 were prospectively studied. Divide them into two groups at random and received conventional treatment (conventional treatment group, n=30) and conventional treatment combined with bacterial lysate (bacterial lysate group, n=30) respectively. The treatment effect was assessed by the days of hospitalization, symptom scores, lung function, and the number of acute exacerbation readmissions within 6 months. The days of hospitalization was 6.77 (6,7) in the bacterial lysate group and 9.47 (8,10) in the control group, which was significantly lower in the bacterial lysate group than in the conventional treatment group (P=0.000). After treatment during hospitalization, procalcitonin decreased more significantly in the bacterial lysate group than in the conventional treatment group (P=0.024). After six months of treatment, the number of acute exacerbations was 0.90 (0,1) times in bacterial lysate group and 1.57 (1,2) times in conventional treatment group. During hospitalization, there was significant difference in 1-second forced expiratory volume (FEV1) and forced vital capacity (FVC) between the two groups and after 6-month follow-up (P=0.048, P=0.045). After 3 and 6 months of treatment, the scores of symptoms and signs in the bacterial lysate group were lower than those in the conventional treatment group. In the acute exacerbation of COPD, oral administration of bacterial lysates can reduce the number of exacerbations of COPD. shorten the days of hospitalization, improve the quality of life of patients, and delay the decline of lung function.


Bacterial Lysate, COPD, Immune, Acute Exacerbation


Yafei Qi, Weimin Zhang and Yinhuan Li, Intervention of Bacterial Lysate in Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Bacteriology and Microbiology (2022) Vol. 2: 1-9. DOI:


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