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Platinum Nanoparticles in Cancer Therapy: Physicochemical Properties, Synthesis, Functionalization, and Therapeutic Applications

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DOI: 10.23977/medbm.2026.040105 | Downloads: 0 | Views: 69

Author(s)

Xiaowei Chang 1, Shasha Jiang 1, Jinjin Liu 1

Affiliation(s)

1 Yan'an University, Yan'an, China, 716000

Corresponding Author

Xiaowei Chang

ABSTRACT

Platinum nanoparticles (PtNPs) have attracted increasing attention in cancer therapy due to their controllable size, large surface area, catalytic activity, and favorable biocompatibility. These features enable PtNPs to overcome limitations of conventional therapies and provide new opportunities for precision oncology. However, a systematic overview of their properties, synthesis, functionalization, and applications remains lacking. This review summarizes the physicochemical properties of PtNPs and discusses their synthesis methods and surface functionalization strategies for regulating structure, stability, and biological performance. Recent advances in PtNP-based applications are highlighted, including drug delivery, photothermal therapy (PTT), photodynamic therapy (PDT), catalytic oxygen generation, and multimodal synergistic therapy. These approaches demonstrate the potential of PtNPs to modulate the tumor microenvironment, enhance reactive oxygen species (ROS) generation, and improve therapeutic efficacy. Overall, PtNP-based nanoplatforms represent a promising strategy for advanced cancer therapy and potential clinical translation.

KEYWORDS

Platinum nanoparticles, Cancer therapy, Drug delivery

CITE THIS PAPER

Xiaowei Chang, Shasha Jiang, Jinjin Liu. Platinum Nanoparticles in Cancer Therapy: Physicochemical Properties, Synthesis, Functionalization, and Therapeutic Applications. MEDS Basic Medicine (2026). Vol. 4, No. 1, 38-45. DOI: http://dx.doi.org/10.23977/medbm.2026.040105.

REFERENCES

[1] Sadalage PS, Dar MA, Bhor RD, et al. Optimization of biogenic synthesis of biocompatible platinum nanoparticles with catalytic, enzyme mimetic and antioxidant activities. Food Bioscience, 2022, 50:102024.
[2] Mehmood S, Iraqui S, Ojha RK, et al. Therapeutic potential and toxicological challenges of metal nanoparticles in drug delivery: A comprehensive review. Nanomedicine: Nanotechnology, Biology and Medicine, 2025, 70:102862.
[3] Subhan MA, Yalamarty SSK, Filipczak N, et al. Recent advances in tumor targeting via EPR effect for cancer treatment. Journal of Personalized Medicine, 2021, 11(6).
[4] Wang C, Li Q, Song K, et al. Nanoparticle co-delivery of carboplatin and PF543 restores platinum sensitivity in ovarian cancer models through inhibiting platinum-induced pro-survival pathway activation. Nanoscale Advances, 2024, 6(16):4082-4093.
[5] Zhang Y, Li C, Wang Z. Porous platinum nanocages with high specific surface area and low-coordinated atoms for efficient photoelectrochemical energy conversion. Nano Energy, 2023, 109:108321.
[6] Khajegi P, Rashidi-Huyeh M. Thermo-optical properties of gold nanoparticles: shape and size effects. SID Symposium Digest of Technical Papers, 2021, 52(1):41-44.
[7] Xu Z, Chen J, Li Y, et al. Yolk-shell Fe3O4@Carbon@Platinum-Chlorin e6 nanozyme for MRI-assisted synergistic catalytic-photodynamic-photothermal tumor therapy. Journal of Colloid and Interface Science, 2022, 628:1033-1043.
[8] Gu T, Wang Y, Lu Y, et al. Platinum nanoparticles to enable electrodynamic therapy for effective cancer treatment. Advanced Materials, 2019, 31(14):e1806803.
[9] Wawrowicz K, Żelechowska-Matysiak K, Majkowska-Pilip A, et al. Platinum nanoparticles labelled with iodine-125 for combined chemo–Auger electron therapy of hepatocellular carcinoma. Nanoscale Advances, 2023, 5(12):3293-3303.
[10] Qiao J, Liu Y, Zhang H. Synergistic Pt single-atom and Pt nanoparticle catalysts anchored on N-doped mesoporous carbon architecture boosting high-performance oxygen reduction in PEMFCs. Applied Catalysis B: Environmental & Energy, 2026.
[11] Li Z, Wang X, Chen J. PEG-modified platinum nanoparticles with dual enzymatic activities for bidirectional regulation of tumor microenvironment redox balance. Advanced Functional Materials, 2024, 34(18):2312045.
[12] Zhang L, Chen W, Liu C. Green and controlled synthesis of platinum nanoparticles: methods, mechanisms, and emerging applications. Small, 2024, 20(22):2400897.
[13] Fini R, Magnani M, Santilli CV, et al. Tuning the formation and growth of platinum nanoparticles using surfactant: in situ SAXS study of the aggregative growth mechanism. ACS Applied Materials & Interfaces, 2025, 17(28):41237-41248.
[14] Wang C, Li M, Zhang Q. Aqueous-phase controlled synthesis of platinum nanoparticles via sodium borohydride reduction: effects of reaction parameters on size and morphology. ACS Nano, 2025, 19(3):4120-4132.
[15] Chen Y, Liu S, Wang X. Comparative study of citrate and ascorbic acid reduction methods for green synthesis of platinum nanoparticles with enhanced biocompatibility. Biomaterials, 2024, 332:122156.
[16] Zhao H, Chen F, Li Y. Stabilizer-regulated dispersibility of platinum nanoparticles synthesized via chemical reduction for enhanced catalytic performance. ACS Applied Materials & Interfaces, 2024, 16(31):36245-36256.
[17] Xin Y, Nagata T, Kato K, et al. Role of polyvinylpyrrolidone in the polyol synthesis of platinum nanoparticles. Nanoscale Advances, 2024, 6(12):3034-3040.
[18] Wang Y, Zhang L, Li C. Chitosan-stabilized platinum nanoparticles: adsorption mechanism, protective layer formation, and long-term dispersion stability. Journal of Colloid and Interface Science, 2024, 656:789-801.
[19] Li S, Zhang Y, Wang L. MOF-derived carbon-supported platinum nanoparticles with ultrahigh specific surface area for catalytic tumor therapy. Acta Biomaterialia, 2024, 103:458-472.
[20] Chen M, Wang H, Zhang S. Dendritic platinum nanoparticles: low-coordinated atoms-mediated biomolecule binding and high specific surface area for enhanced biocatalysis. Biomaterials Science, 2025, 13(5):1289-1302.
[21] Liu J, Zhang X, Li W. High-index faceted platinum nanoparticles with abundant low-coordinated atoms for boosted catalytic activity. Advanced Materials, 2024, 36(17):2311089.
[22] Kim HJ, Park SY, Lee JH. Thermodynamic insight into surface modification of platinum nanoparticles: reducing surface free energy for enhanced dispersion stability. Langmuir, 2024, 40(23):7218-7229.
[23] Li X, Zhang C, Wang J. Tuning oxygen reduction catalytic performance of platinum nanoparticles via surface modification with aromatic ring-sized phosphine ligands. ACS Catalysis, 2024, 14(19):12876-12888.
[24] Gutiérrez De La Rosa SY, Muñiz Diaz R, Villalobos Gutiérrez PT, et al. Functionalized platinum nanoparticles with biomedical applications. International Journal of Molecular Sciences, 2022, 23(16).
[25] Zhang S, Li C, Wang H. Functional group-mediated morphology control of platinum nanoparticles via coordination binding during synthesis. ACS Nano, 2023, 17(12):12109-12121.
[26] Wang X, Zhang H, Li M. Pt@BSA-IRGD nanoclusters via Sulfo-SMCC crosslinking for targeted tumor accumulation and low toxicity therapy. Journal of Controlled Release, 2024, 376:689-703.
[27] Chen J, Liu Y, Zhang C. HER2 antibody-conjugated platinum nanoparticles for high-affinity recognition of breast cancer biomarkers. Advanced Healthcare Materials, 2025, 14(8):2403129.
[28] Li Y, Wang Z, Zhao J. IRGD peptide-mediated tumor penetration via integrin αvβ3 for enhanced platinum nanoparticle delivery. Biomaterials, 2024, 351:124987.
[29] Zhang W, Li Y, Wang H. Hyaluronic acid-coated platinum nanoparticles for CD44-targeted tumor delivery: enhanced circulation half-life and intracellular uptake. Acta Biomaterialia, 2024, 105:789-803.
[30] Chen L, Liu Z, Zhang Y. HA-coated platinum nanoparticles loaded with doxorubicin for synergistic tumor therapy via CD44-mediated endocytosis. Advanced Healthcare Materials, 2025, 14(12):2404567.
[31] Li M, Wang X, Zhang C. PEGylated platinum nanoparticles: stealth effect for reducing RES clearance and enhancing EPR-mediated tumor targeting. Biomaterials, 2024, 356:125123.
[32] Wang Y, Li C, Zhang H. Dual PEG-HA coating of platinum nanoparticles for synergistic enhancement of circulation time and CD44-targeted tumor delivery. ACS Nano, 2023, 17(8):7654-7668.
[33] Kim HJ, Lee SH, Park JH. Platinum nanoparticles in drug delivery: biocompatibility, stability, and targeting strategies. Advanced Drug Delivery Reviews, 2024, 201:115089.
[34] Zhang X, Wang Y, Li C. Synergistic regulation of size, surface charge, and PEGylation density on in vivo circulation and tumor retention of platinum nanoparticles. ACS Nano, 2025, 19(5):7890-7905.
[35] Rajput A, Singh R, Mishra S. Chemically bonded doxorubicin on platinum nanoparticles for targeted drug delivery in cancer therapy. Journal of Biomedical Nanotechnology, 2023, 19(11):1890-1902.
[36] Chen W, Zhang H, Liu S. Lipid-polymer hybrid coated platinum nanoparticles: enhanced biocompatibility, reduced toxicity, and efficient drug encapsulation. Biomaterials, 2024, 340:122567.
[37] Li Y, Zhang M, Wang H. Small-size platinum nanoparticles for enhanced tumor accumulation via EPR effect in breast cancer models. Journal of Controlled Release, 2024, 365:890-903.
[38] Wang L, Zhang H, Li J. RGD peptide-functionalized platinum nanoparticles for active targeting of tumor cells via integrin αvβ3 receptors. Journal of Nanobiotechnology, 2023, 21(1):326.
[39] Liu J, Chen W, Li M. Dual pH-enzyme sensitive platinum nanoparticles for tumor-specific drug release. Advanced Science, 2024, 11(18):2400567.
[40] Wang Z, Li S, Zhang Q. Intrinsic antitumor activity of platinum nanoparticles via oxidative stress induction and DNA replication interference. ACS Applied Bio Materials, 2025, 8(3):2890-2904.
[41] Ren Q, Chen Z, Liu S. Platinum nanoparticles-mediated synergistic therapy: intrinsic antitumor activity combined with photodynamic-chemotherapy. Journal of Colloid and Interface Science, 2024, 668:88-97.
[42] Abed A, Karimi M, Nejati M, et al. Synthesis of 5-fluorouracil coated platinum nanoparticles and apoptotic effects on U87 human glioblastoma cells. Cancer Cell International, 2025, 25(1).
[43] Kumar P, Patel H, Sharma M. PEGylated platinum nanospheres for safe and effective in vivo photothermal therapy: biocompatibility and tumor ablation efficacy. Journal of Nanobiotechnology, 2023, 21(1):458.
[44] Zhao X, Sun Y, Wang C. Morphology-controlled platinum nanoparticles for enhanced near-infrared photothermal therapy of tumors. Advanced Functional Materials, 2024, 34(28):2401896.
[45] Ma Z, Zhang Y, Zhang J, et al. Ultrasmall peptide-coated platinum nanoparticles for precise NIR-II photothermal therapy by mitochondrial targeting. ACS Applied Materials & Interfaces, 2020, 12(35):39434-39443.
[46] Zhang J, Xu X, Wei H, et al. Pt/Pd dual-modified porphyrin metal-organic frameworks for NIR-II photothermal-enhanced photodynamic/catalytic therapy. Journal of Colloid and Interface Science, 2025, 678:42-52.
[47] Yadav D, Sharma P, Mishra P, et al. Management of cancer using photodynamic therapy: advancement and applications. Current Cancer Therapy Reviews, 2024, 20(4):357-371.
[48] Zhang W, Li J, Wang X. Platinum nanoparticles as catalytic oxygen generators to alleviate tumor hypoxia for enhanced photodynamic therapy. Journal of Nanobiotechnology, 2024, 22(1):216.
[49] Liu XL, Dong X, Yang SC, et al. Biomimetic liposomal nanoplatinum for targeted cancer chemophototherapy. Advanced Science, 2021, 8(8):2003679.
[50] Hao R, Zhang G, Zhang J, et al. Ultrasmall Au/Pt-loaded biocompatible albumin nanospheres to enhance photodynamic/catalytic therapy via triple amplification of glucose-oxidase/catalase/peroxidase. Journal of Colloid and Interface Science, 2024, 654:212-223.
[51] Zhang Y, Wang F, Liu C, et al. Nanozyme decorated metal-organic frameworks for enhanced photodynamic therapy. ACS Nano, 2018, 12(1):651-661.
[52] Liu X, Chu Z, Chen B, et al. Cancer cell membrane-coated upconversion nanoparticles/Zn(x)Mn(1-x)S core-shell nanoparticles for targeted photodynamic and chemodynamic therapy of pancreatic cancer. Materials Today Bio, 2023, 22:100765.
[53] Zhang Y, Gao W, Ma Y, et al. Integrating Pt nanoparticles with carbon nanodots to achieve robust cascade superoxide dismutase-catalase nanozyme for antioxidant therapy. Nano Today, 2023, 49.
[54] Faderin E, Iorkula TH, Aworinde OR, et al. Platinum nanoparticles in cancer therapy: chemotherapeutic enhancement and ROS generation. Medical Oncology, 2025, 42(2):42.
[55] Wang T, Liu T, Li Z, et al. Ultrasmall gold-encapsulated mesoporous platinum to promote photodynamic/catalytic therapy through cascade enzyme-like reactions. Journal of Colloid and Interface Science, 2025, 680:117-128.
[56] Feng M, Xiao S, Liu Z, et al. Multifunctional platinum-doped porous FeS₂ nanoparticles for photothermal-enhanced photodynamic ferroptosis combination therapy. Materials Today Nano, 2023, 23:100371.

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