Author(s)

Wenjin Huang ¹, Xuemei Li ¹, Zhumei Wei ¹, Linlu Chen ¹, Yongfu Tang ¹, Jiaguo Liang ¹, Bowei Jiang ¹, Linfeng Zhong ¹, Zukang Deng ¹, Shuqiu Zhang ^2,3

Affiliation(s)

¹ College of Clinical Medical, Youjiang Medical University for Nationalities, Baise, Guangxi, 533000, China
² Baise Sober Technology Co., Ltd., Baise, Guangxi, 533000, China
³ Guangxi Xinghuo Biotechnology Co., Ltd., Baise, Guangxi, 533000, China

Corresponding Author

Shuqiu Zhang

ABSTRACT

To explore the impacts of Guangxi sweet tea and Shutangbao on β-amyloid protease 1 (BACE1) in aluminum maltol-poisoned mice and compare their effects on mice's cognitive and memory functions. Sixty KM mice were randomly grouped. Mice in the model group, treatment group 1 (with Guangxi sweet tea), and treatment group 2 (with Shutangbao) were intraperitoneally injected with 0.3ml aluminum maltol solution per mouse for 30 days. The Y-maze test measured memory[1]. Serum and brain tissue were sampled for relevant detections including biochemical indicators and enzyme activities. For blood glucose, significant differences were seen among groups before and after modeling and after taking medicine. For enzyme activities, β-secretase increased in the model group but decreased in treatment groups. α- and γ-secretase activities were higher in the normal group. These enzyme changes are closely related to the pathological process of Alzheimer's disease, suggesting that the intervention of sweet tea and Shutangbao may have a positive impact on alleviating cognitive impairment. Both sweet tea and Shutangbao can lower blood glucose. Aluminum maltol affects BACE1 expression, impairing memory. They may regulate BACE1 via blood glucose reduction and improve memory effectively.

KEYWORDS

Mice; Blood Sugar; Learning and Memory Ability; Aluminum Maltol; BACE1; Treatment

CITE THIS PAPER

Wenjin Huang, Xuemei Li, Zhumei Wei, Linlu Chen, Yongfu Tang, Jiaguo Liang, Bowei Jiang, Linfeng Zhong, Zukang Deng, Shuqiu Zhang, Experimental Study on the Effects of Guangxi Sweet Tea and Shutangbao on β-amyloid Protease 1 (BACE1) and Cognitive and Memory Functions in Mice Exposed to Maltol Aluminum. Plant Nutrition & Soil Science International (2024) Vol. 3: 9-18. DOI: http://dx.doi.org/10.23977/pnssi.2024.030102.

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