Author(s)

Yunlong Zhong ¹, Jiaji Zhang ¹, Shoutian Li ¹

Affiliation(s)

¹ School of Forensic Medicine, Zunyi Medical University, Zunyi, Guizhou, 56300, China

Corresponding Author

Shoutian Li

ABSTRACT

Patients with acute ischemic cerebrovascular and cardiovascular disease develop ischemia-reperfusion injury (IRI) after normal blood flow is restored to the affected area. This phenomenon is related to calcium homeostasis. Homeostasis of intracellular calcium is essential for maintaining cellular vital activities. This paper is divided into five parts based on the actual scenario, and analyzes in detail the research progress of calcium homeostasis and its dysregulation in ischemia-reperfusion injury. Firstly, the regulatory mechanism of calcium ion homeostasis was analyzed, and then the effect of ischemia-reperfusion injury on calcium homeostasis was discussed. Then, the treatment strategies for calcium homeostasis dysregulation and regulation of calcium homeostasis in ischemia-reperfusion injury were elucidated. Finally, this article summarizes this topic and aims to provide reference materials for researchers in the field.

KEYWORDS

Ischemia-reperfusion injury; calcium homeostasis; calcium overload; study

CITE THIS PAPER

Yunlong Zhong, Jiaji Zhang, Shoutian Li, Calcium homeostasis and its dysregulation in ischemia-reperfusion injury: A study. MEDS Basic Medicine (2024) Vol. 2: 1-6. DOI: http://dx.doi.org/10.23977/medbm.2024.020201.

REFERENCES

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[6] Jing W ,Hai-hua W ,Ping-ping Z , et al. Regulation Mechanism of Ginkgo-Dipyridamolum for Calcium Homeostasis on Cardioprotective Effect During Ischemia Reperfusion Injury [J]. Journal of Chinese medicinal materials, 2015, 38 (12): 57-62.
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