Author(s)

Peng Ren ¹, Bailin He ², Yu Du ², Di Shan ¹, Bingxuan Li ¹, Rulin Jia ¹

Affiliation(s)

¹ College of Criminal Science and Technology, Criminal Investigation Police University of China, Shenyang, Liaoning, 110854, China
² College of Forensic Medicine, China Medical University, Shenyang, Liaoning, 110122, China

Corresponding Author

Peng Ren

ABSTRACT

The case of fat embolism is frequently encountered in forensic practice. Fat embolus enters into the bloodstream and blocks the circulation of multiple organs, and leads to death in severe cases. However, the relationship between the degree of fat embolism and its lethality remains unclear under microscopic examination in forensic pathology. In addition, the main lesion site of fat embolism is controversial. In this study, we retrospectively examined cases of death by fat embolism, and quantified the degree of fat emboli in the lung, cerebrum and kidney with Sudan Ⅲ stain. Our quantified data further refined the examination of fat embolism in forensic pathology by comparing it with previous morphological descriptions. Our results also indicate that pulmonary fat embolism is the most common in forensic examinations in the majority of the death cases of fat embolism within 48 hours after injury. However, cerebral fat embolism may play an important role in the death case of multiple organs over 48 hours after injury. 

KEYWORDS

Pulmonary Fat Embolism, Forensic Pathology, Cerebrum, Kidney, Grade

CITE THIS PAPER

Peng Ren, Bailin He, Yu Du, Di Shan, Bingxuan Li, Rulin Jia, Frequency and Intensity of Fat Particles in Multiple Organs in Lethal Fat Embolism. Social Medicine and Health Management (2024) Vol. 5: 56-62. DOI: http://dx.doi.org/10.23977/socmhm.2024.050109.

REFERENCES

[1] Samdanci, E.T. et al.  Histopathological evaluation of autopsy cases with isolated pulmonary fat embolism (IPFE): is cardiopulmonary resuscitation a main cause of death in IPFE? Open Access Emerg. Med. 11, 121-127 (2019).
[2] Akhtar, S. Fat embolism. Anesthesiol Clin. 27(3):533-550 (2009).
[3] Milroy, C.M., Parai, J.L. Fat Embolism, Fat Embolism Syndrome and the Autopsy. Acad. Forensic Pathol. 9(3-4):136-154 (2019).
[4] Rothberg, D.L., Makarewich, C.A. Fat Embolism and Fat Embolism Syndrome. J. Am. Acad. Orthop. Surg. 27(8):e346-e355 (2019).
[5] Gauss, H.  The pathology of fat embolism. Arch. Surg. 9:593-605 (1924).
[6] Lehmann, E.P., Moore, R.M. Fat embolism including experimental production without trauma. Arch. Surg. 14:621-662 (1927).
[7] Hulman, G. The pathogenesis of fat embolism. J. Pathol. 176(1):3-9 (1995). 
[8] Bulger, E.M., Smith, D.G., Maier, R.V., Jurkovich, G.J. Fat embolism syndrome. A 10-year review. Arch. Surg. 132(4):435-439 (1997).
[9] Falzi, G., Henn, R., Spann, W. On pulmonary fat embolism after injuries with different periods od survival. Munch. Med. Wochenschr. 106:978-981 (1964).
[10] Bolliger, S.A., Muehlematter, K., Thali, M.J., Ampanozi, G. Correlation of fat embolism severity and subcutaneous fatty tissue crushing and bone fractures. Int. J. Legal. Med. 125(3):453-458 (2011).
[11] Mudd, K.L., et al. Analysis of pulmonary fat embolism in blunt force fatalities. J. Trauma. 48(4):711-715 (2000).
[12] Peltier, L.F. Fat embolism A current concept. Clin. Orthop. Relat. Res. 66:241-253 (1969).
[13] Lozman, J., et al. Pulmonary and cardiovascular consequences of immediate fixation or conservative management of long-bone fractures. Arch. Surg. 121(9):992-999 (1986).
[14] Georgopoulos, D., Bouros, D. Fat embolism syndrome: clinical examination is still the preferable diagnostic method. Chest. 123(4):982-983 (2003).
[15] Levy, D. The fat embolism syndrome A review. Clin. Orthop. Relat. Res. 261:281-286 (2003).
[16] Richards, R.R. Fat embolism syndrome. Can. J. Surg. 40(5):334-339 (1997).
[17] Manousakis, G., Han, D.Y., Backonja, M. Cognitive outcome of cerebral fat embolism. J. Stroke. Cerebrovasc. Dis. 21(8):906.e1-3 (2012).
[18] Sevitt, S. The significance and pathology of fat embolism. Ann. Clin. Res. 9(3):173-180 (1977).
[19] Peltier, L. F. Fat embolism: a pulmonary disease. Surgery. 62(4):756-758 (1967).
[20] Aydin, M.D., et al. Mechanism of cerebral fat embolism in subarachnoid hemorrhage: an experimental study. Neuropathology 26(6):544-549 (2006).
[21] Fabian, T. C., Hoots, A. V., Stanford, D.S., Patterson, C.R., Mangiante, E.C. Fat embolism syndrome: prospective evaluation in 92 fracture patients. Crit. Care Med. 18(1):42-46 (1990).

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