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  4. Vol 5, Issue 1, 2024

Pediatric Hypertension: A Study on the Correlation with Biochemical Markers

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DOI: 10.23977/socmhm.2024.050108 | Downloads: 5 | Views: 133

Author(s)

Fengsong Yang 1

Affiliation(s)

1 Department of Laboratory Medicine, The First People's Hospital of Anning City Affiliated with Kunming University of Science and Technology, Anning, Yunnan, 650300, China

Corresponding Author

Fengsong Yang

ABSTRACT

The aim of this study is to investigate the prevalence of hypertension and associated biochemical markers in children and adolescents in China, with a view to informing early intervention strategies to prevent cardiovascular disease (CVD) and reduce related mortality. A cross-sectional study was conducted from June 1, 2020, to October 31, 2022, including 73 students aged 8 to 12 from Anning City, Yunnan Province. Participants, spanning grades 3 to 6, were enrolled with guardian consent. Blood pressure and lipid profiles were the primary metrics. Hypertension categorization followed the 4th Report by the American Academy of Pediatrics and the European Society of Hypertension's 2009 guidelines, with local guidelines for pediatric hypertension also considered. Data on clinical history, physical measurements, and laboratory analyses were compiled, including five blood pressure readings over three days. Fasting blood samples were analyzed for total cholesterol, triglycerides, HDL, and LDL using a Hitachi 008AS biochemical analyzer. Results of the study indicated a distribution within the cohort as follows: normotensive status in 60.2%, prehypertension in 32.9%, and hypertension in 6.9%. Significant differences in total cholesterol, triglycerides, and LDL across blood pressure categories were observed(p<0.005), with higher lipid levels correlating with increased hypertension severity. The LDL/HDL ratio was significantly higher in the hypertensive group(p=6.56e-07). Elevated lipoprotein(a) levels and ApoB/ApoA ratios in hypertensive children pointed to these markers as strong indicators of cardiovascular disease risk. This study highlights a concerning prevalence of prehypertension and hypertension in Chinese children, with significant associations between elevated blood pressure and lipid abnormalities. These findings underscore the need for early monitoring and intervention to address CVD risk in pediatric populations.

KEYWORDS

Hypertension in Children, Prehypertension, Cardiovascular Disease Risk, Lipid Profile, Blood Pressure Categories, Public Health, China

CITE THIS PAPER

Fengsong Yang, Pediatric Hypertension: A Study on the Correlation with Biochemical Markers. Social Medicine and Health Management (2024) Vol. 5: 48-55. DOI: http://dx.doi.org/10.23977/socmhm.2024.050108.

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