Author(s)

Qinfeng Zhang ¹, Weizhuo Wang ²

Affiliation(s)

¹ Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
² Department of Orthopedics Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi'an, Shaanxi, 710004, China

Corresponding Author

Weizhuo Wang

ABSTRACT

In order to explore the possible mechanism of cryptotanshinone (CTS) in the treatment of Kashin-beck disease (KBD) based on network pharmacology, we obtained CTS drug targets from TCMSP, CTD and DGIdb databases, and we searched Genecard, TTD, OMIM and Dragbank databases with "KBD" as the keyword to obtain the disease target of KBD. Drug-disease gene interaction was performed in Venny2.1.0 to obtain the intersection target. String database and Cytoscape 3.7.1 were used for protein-protein interaction network (PPI) analysis, and DAVID database was used for GO enrichment and KEGG enrichment pathway analysis. The "drug-target-pathway-disease" network diagram was constructed by Cytoscape. Resultly, a total of 10 key targets were selected, 125 items in 3 directions were obtained by GO enrichment analysis, and 34 signaling pathways were obtained by KEGG enrichment analysis. In conclusion, through network pharmacological analysis, CTS can treat KBD through multi-target and multi-pathway. 

KEYWORDS

Cryptotanshinone; Kashin-beck disease; Network pharmacology

CITE THIS PAPER

Qinfeng Zhang, Weizhuo Wang, Exploration on the Mechanism of Cryptotanshinone in Treating Kashin-beck Disease Based on Network Pharmacology. MEDS Basic Medicine (2024) Vol. 2: 8-14. DOI: http://dx.doi.org/10.23977/medbm.2024.020102.

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