Author(s)

Nida Aslam ¹, Salamaiti Aimaier ¹, Tuersunjiang Naman ¹, Ailiman Mahemuti ¹

Affiliation(s)

¹ Department of Heart Failure, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China

Corresponding Author

Ailiman Mahemuti

ABSTRACT

The endoplasmic reticulum (ER) and mitochondria are physically connected to form dedicated structural domains known as mitochondria-associated ER membranes (MAMs), MAMs is involved in Ca²⁺ transfer, Lipid synthesis and transfer, mitochondrial dynamics, ER stress, mitophagy, inflammation and apoptosis.  Many studies have proved MAMs is related to the occurrence of cardiovascular diseases, Parkinson's disease, Alzheimer's disease, diabetes and metabolic diseases.  Here, we review the knowledge regarding the components of MAMs according to their different functions and the specific roles of MAMs in heart failure.

KEYWORDS

Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs), heart failure

CITE THIS PAPER

Nida Aslam, Salamaiti Aimaier, Tuersunjiang Naman, Ailiman Mahemuti, Potential Role of Mitochondria-Associated Endoplasmic Reticulum Membranes in Heart Failure. MEDS Basic Medicine (2023) Vol. 1: 105-109. DOI: http://dx.doi.org/10.23977/medbm.2023.010216.

REFERENCES

[1] Yang L, Wang L, Deng Y, et al. Serum lipids profiling perturbances in patients with ischemic heart disease and ischemic cardiomyopathy[J]. Lipids Health Dis, 2020, 19(1): 89. 
[2] Silva-Palacios A, Zazueta C, Pedraza-Chaverri J. ER membranes associated with mitochondria: Possible therapeutic targets in heart-associated diseases[J]. Pharmacological Research, 2020:104758. 
[3] Gunter T E, Gunter K K, Sheu S S, et al. Mitochondrial calcium transport: physiological and pathological relevance[J]. Am. j. physiol, 1994, 267(2 Pt 1):C313. 
[4] Fernandes T, Resende R, Silva D F, et al.  Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer's Disease[J]. Biomedicines, 2021, 9(8) (881). 
[5] Hu, L, Ding, M, Tang, D, et al. Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy. Theranostics. 2019; 9 (13): 3687-3706. 
[6] Wang N, Wang C, Zhao H, et al. The MAMs Structure and Its Role in Cell Death[J]. Cells, 2021, 10(3):657. 
[7] Mao, H, Chen, W, Chen, L, Li, L.  Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases.  BIOCHEM PHARMACOL.  2022-05-01; 199 115011. 
[8] Giorgi, C, Marchi, S, Pinton, P. The machineries, regulation and cellular functions of mitochondrial calcium.  NAT REV MOL CELL BIO.  2018; 19 (11): 713-730. 
[9] Mao H, Chen W, Chen L, et al. Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases[J]. Biochemical Pharmacology, 2022, 199:115011-.DOI:10.1016/j.bcp.2022.115011.
[10] B Y G A, B J L A, B Z M A, et al. Mitochondria-associated membrane-modulated Ca2+ transfer: A potential treatment target in cardiac ischemia reperfusion injury and heart failure[J]. Life sciences, 278:119511. 
[11] Gao, P, Yan, Z, Zhu, Z. Mitochondria-Associated Endoplasmic Reticulum Membranes in Cardiovascular Diseases.  Front Cell Dev Biol.  2020; 8 604240. 
[12] Ghosh S, Ball W B, Madaris T R, et al. An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter[J]. Proceedings of the National Academy of Sciences, 2020, 117(28):202000640. 
[13] A. E. Frakes, A. Dillin, The UPR ER: sensor and coordinator of organismal homeostasis, Mol. Cell 66 (2017) 761–771. 
[14] Rong-Rong W, Shou-Bao W, Guan-Hua D U. Roles of mitochondria-associated endoplasmic reticulum membranes in ischemic stroke[J]. Chinese Pharmacological Bulletin, 2019.
[15] Pierre, Theurey, Emily, et al. Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver[J]. Journal of molecular cell biology, 2016. DOI:10.1093/jmcb/mjw004.

Sponsors, Associates, and Links

---

• MEDS Clinical Medicine
  
  
• Journal of Neurobiology and Genetics
  
  
• Medical Imaging and Nuclear Medicine
  
  
• Bacterial Genetics and Ecology
  
  
• Transactions on Cancer
  
  
• Journal of Biophysics and Ecology
  
  
• Journal of Animal Science and Veterinary
  
  
• Academic Journal of Biochemistry and Molecular Biology
  
  
• Transactions on Cell and Developmental Biology
  
  
• Rehabilitation Engineering & Assistive Technology
  
  
• Orthopaedics and Sports Medicine
  
  
• Hematology and Stem Cell
  
  
• Journal of Intelligent Informatics and Biomedical Engineering
  
  
• MEDS Stomatology
  
  
• MEDS Public Health and Preventive Medicine
  
  
• MEDS Chinese Medicine
  
  
• Journal of Enzyme Engineering
  
  
• Advances in Industrial Pharmacy and Pharmaceutical Sciences
  
  
• Bacteriology and Microbiology
  
  
• Advances in Physiology and Pathophysiology
  
  
• Journal of Vision and Ophthalmology
  
  
• Frontiers of Obstetrics and Gynecology
  
  
• Digestive Disease and Diabetes
  
  
• Advances in Immunology and Vaccines
  
  
• Nanomedicine and Drug Delivery
  
  
• Cardiology and Vascular System
  
  
• Pediatrics and Child Health
  
  
• Journal of Reproductive Medicine and Contraception
  
  
• Journal of Respiratory and Lung Disease
  
  
• Journal of Bioinformatics and Biomedicine