Recent Advances in Mesenchymal Stem Cell-mediated Bone Regeneration

Yundong Fan; Guiquan Chen

doi:10.23977/medbm.2023.010215

Recent Advances in Mesenchymal Stem Cell-mediated Bone Regeneration

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DOI: 10.23977/medbm.2023.010215 | Downloads: 2 | Views: 227

Author(s)

Yundong Fan ^1,2, Guiquan Chen ^1,2

Affiliation(s)

¹ School of Integrated Traditional Chinese and Western Medicine, Southwest Medical University, Luzhou, Sichuan, 646608, China
² Department of Acupuncture and Moxibustion, Rehabilitation Massage, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China

Corresponding Author

Guiquan Chen

ABSTRACT

Bone plays an important role in the normal physiological activities of the human body, such as mechanical support, organ protection and maintenance of mineral homeostasis. Different degrees of bone defects can lead to functional limitation and cosmetic deformity of patients and promoting bone regeneration ability is a current research focus. Among them, mesenchymal stem cells (MSCs) are a major research hotspot in the field of regenerative medicine in recent years and have been widely used in clinical studies of various bone tissue regeneration. Many studies have shown that the bone regeneration effect of MSCs can directly or indirectly improve the aging, migration, proliferation and differentiation of MSCs to promote bone regeneration and accelerate the process of bone repair by changing the microenvironment, reducing inflammatory infiltration, regulating the balance between bone and immune system, and increasing angiogenesis and regulating dysbacteriosis. This review summarizes the function and mechanism of MSCs in bone regeneration and repair. Understanding the mechanism behind will help understand the process of MSC-mediated bone remodeling and optimization of MSC-based therapy will guide the treatment of bone regeneration and provide new and customizable cell-based treatment strategies to promote bone regeneration in vivo.

KEYWORDS

Bone regeneration; mesenchymal stem cells (MSCs); osteogenic differentiation; microenvironment; angiogenesis

CITE THIS PAPER

Yundong Fan, Guiquan Chen, Recent Advances in Mesenchymal Stem Cell-mediated Bone Regeneration. MEDS Basic Medicine (2023) Vol. 1: 97-104. DOI: http://dx.doi.org/10.23977/medbm.2023.010215.

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Recent Advances in Mesenchymal Stem Cell-mediated Bone Regeneration

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ABSTRACT

KEYWORDS

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