Author(s)

Xiaomeng Zheng ¹, Xiaodong Li ², Yanan Meng ¹

Affiliation(s)

¹ Department of Clinical Laboratory, Affliated Hospital of Hebei University, Baoding, 071000, China
² Department of Nuclear Medicine, Affliated Hospital of Hebei University, Baoding, 071000, China

Corresponding Author

Yanan Meng

ABSTRACT

Cytokines are a general term for polypeptide cell regulatory substances, including interleukin, interferons, growth factors, cell stimulating factors, tumor necrosis factor and so on. It is mainly composed of immune cells (T cells, B cells, macrophages, etc.) and some non-immune cells (endothelial cells, fibroblasts), a kind of small molecule proteins with a wide range of biological activity, with various functions such as regulating immunity, promoting blood cell generation, cell growth and repair of damaged tissues. Cytokines also play an important role in the pathogenesis, diagnosis, drug efficacy and prognosis evaluation of hematological and immune system diseases. However, in the clinical reports, the normal control has a small sample size, narrow coverage, regional differences and different detection techniques, and the reported results are lack of comparable, so it is very important to establish the reference value range of cytokines in the normal population in this region. At present, there is no epidemiological report of inflammatory cytokine levels in normal population in Baoding. Therefore, the flow cytometry microsphere array method (cytometric bead arry, CBA) can detect several soluble proteins at one time, The serum levels of IL-1 β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-8, IL-10, IL-12P70, IL-17A, IFN- α, TIFN- α and IFN- γ in multiple levels of cytokines, To provide a basis for determining the normal reference values of these factors in the Baoding area, It also lays the foundation for the subsequent research of related diseases.

KEYWORDS

Inflammatory cytokines, interleukins, and reference value range

CITE THIS PAPER

Xiaomeng Zheng, Xiaodong Li, Yanan Meng, Measurement of reference value range of serum inflammatory cytokines in normal population in Baoding area. Social Medicine and Health Management (2023) Vol. 4: 49-53. DOI: http://dx.doi.org/10.23977/socmhm.2023.040507.

REFERENCES

[1] Chen Ying, Zhang Wenling, Huang Tao, et al. Association between the inflammatory cytokines TNF- α, IL-6, and IL-17 and rheumatoid arthritis complicated with atherosclerosis [J]. Journal of Immunology, 2017, 3 (3): 268.
[2] Feng TF. Effect of azithromycininfusion time on the level of airway inflammatory cytokines in children with Mycoplasma pneumonia [J]. Maternal and Child Health Care of China, 2021, 36 (8): 1796-1799. 
[3] Xu L, Zhao Y, Wu S, et al. Effects of adjuvant pidotimod therapy on levels of inflammatory factors and expressions of serum GM-CSF and KL-6 in elderly patients with Mycoplasma pneumonia [J].Am J Transl Res, 2021, 13(10): 11899-11907.       
[4] Wehr P, Purvis H,Law S C,et al.Dendritic cells,T cells and their interaction in rheumatoid arthritis [J].Clin Exp Immunol, 2019, 196(1:12-27).
[5] Aziguli Abdu Rehman, Han Yuming. Correlation study of serum Th 1 / Th 2-related factors and immune function in HCC patients [J]. International Journal of Laboratory Medicine, 2018, 39 (6): 737-741.
[6] Boskabadi H,Maamouri G,Afshari J T,et al.Evaluation of serum interleukins-6,8 and 10 levels as diagnostic markers of neonatal infection and possibility of  mortality[J].Iran J Basic Med Sci,2013,16(12):1232–1237.
[7] Lan Xuan, Li Zhaoming, Zhang Mingzhi, determination of serum inflammatory cytokine reference value range in normal population in Zhengzhou [J].Journal of Zhengzhou University (Medical edition) 2018,3 (5): 341-343.
[8] Xu Xiaojun, Tang Yongmin, Zhao Ning, et al. Significance of Th 1 / Th 2 cytokine profiles in the diagnosis of hemophagocytic syndrome in children [J]. Chinese Journal of Pediatrics, 2011, 49 (9): 685.
[9] Tang Y,Xu X.Song H,et al.Early diagnostic and prognostic significance of a specific Th1/Th2 cytokine pattern in children with haemophagocytic syndrome[J].Br J Haematol, 2008,143(1):84.
[10] Huang Z, Chen B, Liu X, Li H, Xie L, Gao Y, Duan R, Li Z, Zhang J, Zheng Y, Su W.Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis.Proc Natl Acad Sci U S A.2021 Aug 17;118(33):e2023216118. doi: 10.1073/pnas.2023216118. PMID: 34385315; PMCID: PMC8379935.

Sponsors, Associates, and Links

---

• Information Systems and Economics
  
  
• Accounting, Auditing and Finance
  
  
• Industrial Engineering and Innovation Management
  
  
• Tourism Management and Technology Economy
  
  
• Journal of Computational and Financial Econometrics
  
  
• Financial Engineering and Risk Management
  
  
• Accounting and Corporate Management
  
  
• Social Security and Administration Management
  
  
• Population, Resources & Environmental Economics
  
  
• Statistics & Quantitative Economics
  
  
• Agricultural & Forestry Economics and Management
  
  
• Land Resource Management
  
  
• Information, Library and Archival Science
  
  
• Journal of Human Resource Development
  
  
• Manufacturing and Service Operations Management
  
  
• Operational Research and Cybernetics