Author(s)

Qian Wang ¹, Xuezhong Li ², Wenjing Huang ³, Yicao He ¹

Affiliation(s)

¹ Division of Nephrology, Affiliated Hospital of Hebei University, Baoding, 071000, China
² Intensive Care Unit, Affiliated Hospital of Hebei University, Baoding, 071000, China
³ Ultrasound Diagnosis Department, Affiliated Hospital of Hebei University, Baoding, 071000, China

Corresponding Author

Xuezhong Li

ABSTRACT

The study aimed to explore the relationship between serum miR-297a levels and vascular calcification in Maintenance Hemodialysis (MHD) patients. One hundred and forty stable MHD patients, treated for at least six months, were categorized into three groups based on vascular calcification severity: no calcification (37 cases), mild calcification (55 cases), and severe calcification (48 cases). The research involved analyzing various blood parameters like calcium, phosphorus, urea, creatinine, albumin, alkaline phosphatase, hemoglobin, and parathyroid hormone levels using biochemical analyzers and ELISA. The Agatston score was employed to assess calcification. MiR-297a levels were measured through miRNA quantitative PCR. The findings revealed a significant decrease in miR-297a levels in the mild and severe calcification groups compared to the non-calcification group. Additionally, logistic regression indicated that serum alkaline phosphatase and miR-297a are risk factors for vascular calcification in MHD patients. These results suggest a link between miR-297a level changes and vascular calcification, proposing miR-297a as a potential regulator of cardiovascular risk in MHD patients. This discovery could lead to new targeted strategies for cardiovascular healthcare in these patients.

KEYWORDS

Maintenance hemodialysis; miR-297a; vascular calcification

CITE THIS PAPER

Qian Wang, Xuezhong Li, Wenjing Huang, Yicao He, Relationship between serum miR-297a level and vascular calcification in maintenance hemodialysis patients. MEDS Basic Medicine (2023) Vol. 1: 73-78. DOI: http://dx.doi.org/10.23977/medbm.2023.010212.

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