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  4. Vol 3, Issue 4, 2022

Research Progress of Aplastic Anemia in Immune Dysfunction

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DOI: 10.23977/medsc.2022.030419 | Downloads: 22 | Views: 770

Author(s)

Zihui Li 1, Zhihui Zhou 2, Yinhai Dai 2, Limei He 1, Hong Li 1,3

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, 712046, China
2 Second Clinnical Medical College, Shaanxi University of Chinese Medicine, Xianyang, 712046, China
3 Pharmaceutical Factory, Shaanxi University of Chinese Medicine, Xianyang, 712046, China

Corresponding Author

Hong Li

ABSTRACT

Aplastic Anemia (AA) is an autoimmune disease mainly mediated by T cells. On the one hand, focusing on the current research status of different T lymphocytes in AA. On the other hand, because a variety of cytokines are involved in the occurrence, development and outcome of AA, the research progress of multiple cytokines (interleukin, interferon and tumor necrosis factor) in the pathogenesis of AA was analyzed at the same time. Facing the current status of recurrence and ineffective IST treatment in clinical treatment, we explore the role of mesenchymal stem cells from different tissues in immunity, and explore their potential therapeutic advantages may bring new ideas for clinical treatment. Exploring the pathogenesis of AA in multiple dimensions will bring about treatment ideas that will also be multi-dimensional.

KEYWORDS

Aplastic anemia (AA), bone marrow failure, immune dysfunction, immune cells, cytokines

CITE THIS PAPER

Zihui Li, Zhihui Zhou, Yinhai Dai, Limei He, Hong Li, Research Progress of Aplastic Anemia in Immune Dysfunction . MEDS Clinical Medicine (2022) Vol. 3: 121-128. DOI: http://dx.doi.org/10.23977/medsc.2022.030419.

REFERENCES

[1] Young NS, Kaufman DW. The epidemiology of acquired aplastic anemia [J]. Haematologica. 2008; 93(4): 489-92.
[2] Chen T, Zhang T, Liu C, et al. NK cells suppress CD8(+) T cell immunity via NKG2D in severe aplastic anemia [J]. Cellular immunology. 2019; 335: 6-14.
[3] Zhang T, Yuan X, Liu C, et al. Decreased TIM-3 expression of peripheral blood natural killer cells in patients with severe aplastic anemia [J]. Cellular immunology. 2017; 318: 17-22.
[4] Medinger M, Drexler B, Lengerke C, et al. Pathogenesis of Acquired Aplastic Anemia and the Role of the Bone Marrow Microenvironment [J]. Frontiers in oncology. 2018; 8: 587.
[5] Young NS. Current concepts in the pathophysiology and treatment of aplastic anemia. Hematology American Society of Hematology Education Program [J]. 2013; 2013(1): 76-81.
[6] Yang S, Wang J, Brand DD, et al. Role of TNF-TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications. Frontiers in immunology [J]. 2018; 9: 784.
[7] Yang L, Liu Z, Li J, et al. Association of the expression of Th cytokines with peripheral CD4 and CD8 lymphocyte subsets after vaccination with FMD vaccine in Holstein young sires [J]. Research in veterinary science. 2018; 119: 79-84.
[8] Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia [J]. Blood. 2006; 108(8): 2509-19.
[9] Young NS, Scheinberg P, Calado RT. Aplastic anemia. Current opinion in hematology [J]. 2008; 15(3): 162-8.
[10] Jin J, Chen F, Wang Q, et al.  Inhibition of TNF-α by cyclophosphamide reduces myocardial injury after ischemia-reperfusion [J]. Annals of thoracic and cardiovascular surgery: official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. 2013; 19(1): 24-9.
[11] Zhao J, Chen J, Huang F, et al. Human gingiva tissue-derived MSC ameliorates immune-mediated bone marrow failure of aplastic anemia via suppression of Th1 and Th17 cells and enhancement of CD4+Foxp3+ regulatory T cells differentiation[J]. American journal of translational research. 2019; 11(12): 7627-43.
[12] Horwitz DA, Fahmy TM, Piccirillo CA, et al. Rebalancing Immune Homeostasis to Treat Autoimmune Diseases [J]. Trends in immunology. 2019; 40(10): 888-908.
[13] Li H, Wang L, Pang Y, et al. In patients with chronic aplastic anemia, bone marrow-derived MSCs regulate the Treg/Th17 balance by influencing the Notch/RBP-J/FOXP3/RORγt pathway [J]. Scientific reports. 2017; 7: 42488.
[14] Li MO, Rudensky AY. T cell receptor signalling in the control of regulatory T cell differentiation and function. Nature reviews Immunology [J]. 2016; 16(4): 220-33.
[15] Qi W, Ren Y, Fu R, et al. Detection and Significance of CD4+CD25+CD127dim Regulatory T Cells in Individuals with Severe Aplastic Anemia [J]. Turkish journal of haematology: official journal of Turkish Society of Haematology. 2015; 32(3): 220-7.
[16] In JW, Lee N, Roh EY, et al. Association of aplastic anemia and FoxP3 gene polymorphisms in Koreans [J]. Hematology (Amsterdam, Netherlands). 2017; 22(3): 149-54.
[17] Kordasti S, Marsh J, Al-Khan S, et al. Functional characterization of CD4+ T cells in aplastic anemia. Blood [J]. 2012; 119(9): 2033-2043. Blood. 2020; 136(9): 1114.
[18] Yan L, Fu R, Liu H, et al. Abnormal quantity and function of regulatory T cells in peripheral blood of patients with severe aplastic anemia [J]. Cellular immunology. 2015; 296(2): 95-105.
[19] Xing L, Liu C, Fu R, Wang H, Wang J, Liu X, et al. CD8+HLA-DR+ T cells are increased in patients with severe aplastic anemia. Molecular medicine reports. 2014; 10(3): 1252-8.
[20] Zheng M, Liu C, Fu R, Wang H, Wu Y, Li L, et al. Abnormal immunomodulatory ability on memory T cells in humans with severe aplastic anemia. International journal of clinical and experimental pathology. 2015; 8(4): 3659-69.
[21] Li Y, Ding S, Liu C, et al. Abnormalities of quantities and functions of CD56bright natural killer cells in non-severe aplastic Anemia [J]. Hematology (Amsterdam, Netherlands). 2019; 24(1): 405-12.
[22] Kronenberg M, Gapin L. The unconventional lifestyle of NKT cells [J]. Nature reviews Immunology. 2002; 2(8): 557-68.
[23] Qiao X, Xie X, Jiang S, et al. Experimental bone marrow failure in mice ameliorated by OCH via tippling the balance of released cytokines from Th1 to Th2 [J]. Immunopharmacology and immunotoxicology. 2012; 34(3): 491-8.
[24] De R, Dutta A, Dolai TK, et al. Comparative study of bone marrow and blood plasma levels of IL-2 in aplastic anaemia and their relationship with disease severity [J]. Hematology (Amsterdam, Netherlands). 2019; 24(1): 84-8.
[25] Wu Z, Giudice V, Chen J, et al. Interleukin-18 plays a dispensable role in murine and likely also human bone marrow failure [J]. Experimental hematology. 2019; 69: 54-64. e2.
[26] Lin FC, Karwan M, Saleh B, et al. IFN-γ causes aplastic anemia by altering hematopoietic stem/progenitor cell composition and disrupting lineage differentiation [J]. Blood. 2014; 124(25): 3699-708.
[27] Lin X, Liu C, Wang T, et al. Sirt1 in the Regulation of Interferon Gamma in Severe Aplastic Anemia [J]. Acta haematologica. 2019; 142(3): 142-8.
[28] Zumerle S, Molon B, Viola A. Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation [J]. Frontiers in immunology. 2017; 8: 1467.
[29] Zhao S, Zhang Y, Huang G, et al. Increased CD8(+) CD27(+) perforin (+) T cells and decreased CD8(+) CD70(+) T cells may be immune biomarkers for aplastic anemia severity [J]. Blood cells, molecules & diseases. 2019; 77: 34-42.
[30] Solomou EE, Keyvanfar K, Young NS. T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia [J]. Blood. 2006; 107(10): 3983-91.
[31] Qiao X, Xie X, Jiang S, et al. Experimental bone marrow failure in mice ameliorated by OCH via tippling the balance of released cytokines from Th1 to Th2 [J]. Immunopharmacology and immunotoxicology. 2012; 34(3): 491-8.
[32] Gu Y, Hu X, Liu C, et al. Interleukin (IL)-17 promotes macrophages to produce IL-8, IL-6 and tumour necrosis factor-alpha in aplastic anaemia [J]. British journal of haematology. 2008; 142(1): 109-14.
[33] Qiao X, Xie X, Jiang S, et al. Experimental bone marrow failure in mice ameliorated by OCH via tippling the balance of released cytokines from Th1 to Th2 [J]. Immunopharmacology and immunotoxicology. 2012; 34(3): 491-8.
[34] Keating SE, Zaiatz-Bittencourt V, Loftus RM, et al. Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells [J]. Journal of immunology (Baltimore, Md: 1950). 2016; 196(6): 2552-60.
[35] Liu C, Li Z, Sheng W, et al. Abnormalities of quantities and functions of natural killer cells in severe aplastic anemia [J]. Immunological investigations. 2014; 43(5): 491-503.
[36] Van de Ven K, Borst J. Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential [J]. Immunotherapy. 2015; 7(6): 655-67.
[37] Shan NN, Jiang YJ, Sui XH, et al. The study of IL-18 and IL-18BP balance in aplastic anemia [J]. Zhonghua xue ye xue za zhi. 2011; 32(11): 783-5.

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